The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle

Roberts, P. J.; Loxham, Susan J. G.; Poucher, Simon M.; Constantin‐Teodosiu, Dumitru; Greenhaff, Paul L.

doi:10.1111/j..2002.t01-1-00591.x

J Physiology

2002

DOI: 10.1111/j..2002.t01-1-00591.x

|View full text |Cite

The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle

P. J. Roberts

Susan J. G. Loxham

Simon M. Poucher

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2015

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 23 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Effect of thiamin (vitamin B<sub>1</sub>) on carbohydrate metabolism at rest and during exercise

Masuda

Hatta

2015

JPFSM

View full text Add to dashboard Cite

Thiamin (vitamin B 1) has often been used as a reagent to prevent fatigue. There are two possibilities concerning the anti-fatigue effect of thiamin: 1) an ergogenic effect in a nonthiamin deficient state and 2) a supplementary effect under the condition of an increasing need for thiamin due to exercise. Thiamin is a coenzyme of pyruvate dehydrogenase (PDH), which is a mitochondrial enzyme for oxidation of carbohydrate-derived substrate to generate ATP. In a thiamin deficiency, oxidation of carbohydrate is decreased due to the reduced activity of PDH. Thus a supplement of thiamin improves carbohydrate metabolism in the thiamin-deficient state. Some reports have indicated that concentrations of thiamin in tissues are decreased by exercise, i.e. the need for thiamin intake is increased. However, direct evidence supporting the hypothesis of whether or not the thiamin requirement is increased by exercise is lacking. Although it is well documented that thiamin plays an important role in the normal function of PDH reactions, whether carbohydrate metabolism is activated by supplemental thiamin during and after exercise in a normal thiamin state is unclear. This review deals with the possibility of the administration of thiamin in preventing exercise-induced fatigue by focusing on two considerations: 1) whether the need for thiamin is increased with exercise and 2) the effect of thiamin not only on carbohydrate metabolism, but also on lipid metabolism at rest and during exercise under normal dietary conditions.

show abstract

Effect of thiamin (vitamin B<sub>1</sub>) on carbohydrate metabolism at rest and during exercise

Masuda

Hatta

2015

JPFSM

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle

Cited by 1 publication

References 23 publications

Effect of thiamin (vitamin B<sub>1</sub>) on carbohydrate metabolism at rest and during exercise

Effect of thiamin (vitamin B<sub>1</sub>) on carbohydrate metabolism at rest and during exercise

Contact Info

Product

Resources

About