The accuracy of fine-needle aspiration cytology for diagnosis of parotid gland masses: a clinicopathological study of 114 patients

GUDMUNDSSON, Jens Kristjan; Ajan, Aida; Abtahi, Jahan

doi:10.1590/1678-775720160214

Cited by 63 publications

(71 citation statements)

References 30 publications

(47 reference statements)

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“…Many studies from 1987 to 2016 have shown high accuracy (81%‐98%) and high specificity (86%‐100%) for the cytological differentiation between benign and malignant salivary gland lesions, with high sensitivity (73%‐95%) . In the report of Colella et al, the accuracy of salivary FNA for benign tumours including WT was also high (95.6%), as well for non‐neoplastic lesions (94.15%) and also good accuracy was found for malignant tumours (79.95%).…”

Section: Diagnostic Accuracy Of Cytopathology For Salivary Gland Lesimentioning

confidence: 96%

“…Meta‐analysis of the data for diagnostic accuracy of salivary gland lesion cytopathology in more than 300 publications also shows that all benign salivary lesions were correctly diagnosed in 92.5% of the cases and a false positive was obtained in 3.3% of the cases . According to Klijanienko and Vielh, correct diagnosis of WT as benign lesion was made in 92.1% cases and false positive were obtained in 2.3% cases .…”

Section: Diagnostic Accuracy Of Cytopathology For Salivary Gland Lesimentioning

confidence: 98%

“…Salivary gland cytopathology is in part a diagnostical challenge due to numerous different neoplasms arising in the salivary glands and overlapping cytomorphological features of so many of these tumours . However, FNA is a reliable diagnostic approach in the diagnosis of salivary gland lesions allowing for a highly accurate categorisation of benign tumour‐like lesions, benign tumours and malignant tumours . In the case of malignancy, tumours could be classified as low or high grade, and further as a specific tumour type.…”

Section: Cytopathology and Fna Of Salivary Gland Lesionsmentioning

confidence: 99%

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Cytopathology and diagnostics of Warthin's tumour

Sučić

Ljubić²,

Perković³

et al. 2020

Cytopathology

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Warthin's tumour (WT) is a benign epithelial salivary tumour, one type of salivary adenoma. Histologically, WT is structured of two components, epithelial tissue that often lines cystic formations and lymphoid tissue in the tumour stroma. FNA is a reliable diagnostic approach in the diagnosis of salivary gland lesions allowing a highly accurate categorization of benign tumour‐like lesions, benign tumours and malignant tumours. In the proposed Milan reporting system of salivary gland lesions, WT is categorized in the IVA group of benign neoplasms. Accurate cytological diagnosis is straightforward when three characteristic components are present: oncocytes, either isolated or associated in clusters, lymphocytes and lymphoid cells and often an inflammatory/necrotic‐like substance. Also, specific features of scintigraphy and radiological imaging contribute to the diagnosis of WT. WT is categorized according to Seifert G. et al in 4 types, depending on the proportions of the epithelial component and lymphoid stroma. Differential cytopathological and pathohistological diagnosis include other salivary gland lesions with lymphoid, oncocytic epithelial and cystic components. In some cases, such as the metaplastic WT variant, there are additional cytopathological and histological diagnostic difficulties. Moreover, bilateral, multicentric or multiple and infrequently seen extra‐salivary localizations of WT are associated with further cytopathological diagnostic difficulties. Also, a rare possibility of malignant transformation of the epithelial or lymphoid component of WT as well as possible association with other primary tumours remains a challenge in accurate cytopathological and histological diagnosis of WT.

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Section: Diagnostic Accuracy Of Cytopathology For Salivary Gland Lesimentioning

confidence: 96%

Section: Diagnostic Accuracy Of Cytopathology For Salivary Gland Lesimentioning

confidence: 98%

Section: Cytopathology and Fna Of Salivary Gland Lesionsmentioning

confidence: 99%

See 1 more Smart Citation

Cytopathology and diagnostics of Warthin's tumour

Sučić

Ljubić²,

Perković³

et al. 2020

Cytopathology

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“…Therefore, in conclusion, it would be advisable from the standpoint of this theory to consider the data of some works in which much attention is paid to evaluating the effectiveness of diagnostic, prediction and classification methods and the results obtained in them appear to be reliable. One such work was devoted to assessing the effectiveness of the FNAC detection method [15]. The introduction describes the essence of this work, in which the numerical values of many efficiency parameters characterizing this method were obtained.…”

Section: Resultsmentioning

confidence: 99%

“…Further, it will be shown that these are fundamentally incorrect judgments, since operating with such canonical concepts as sensitivity and specificity does not lead to an unambiguous assessment of the effectiveness of the methods. Among the works in which the aspect of evaluating the effectiveness of diagnostic methods, prediction and classification is prominent and it seems reliable, should be cited the work of Swedish researchers [15]. The authors of this work set a goal to evaluate the effectiveness of the fine-needle aspiration biopsy method (fine-needle aspiration cytology, FNAC) for diagnosing parotid gland proliferation (parotid gland masses).…”

Section: Evaluation Of the Effectiveness Of Various Methods Of Diagnomentioning

confidence: 99%

About the Evaluation of the Effectiveness of Various Methods of Diagnosis, Prediction and Classification Presented in the Literature

Petrenko¹

2019

IJDSA

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The literature presents a large number of very different ways to diagnose, predict and classify. In support of their usefulness and effectiveness, various parameters are often used, from a large number of them, which are not always necessary and sufficient, since they do not unequivocally characterize efficiency. The purpose of this work was to build a theory in which the characteristic parameters would be clearly defined, necessary and sufficient to identify and evaluate the effectiveness of the method itself and the databases to which this method was applied. On the basis of an objective analysis of all known parameters characterizing the effectiveness of various methods of diagnosing and predicting, necessary and sufficient conditions were determined for them that ensure the unambiguity of the conducted assessments of their effectiveness. Some examples have shown their effectiveness. Full unambiguity and certainty in the reflection of the effectiveness of any method of diagnosis and prediction is achieved only when all the parameters characterizing it are interconnected by one equation. The paper presents a set of such equations, from which it follows that the uniqueness of the evaluation of the effectiveness of any method is achieved only when it is reflected by a triad of characteristic basis parameters. Only such a triad of efficiency parameters, interconnected by characteristic equations obtained in theory, that is, in a deterministic way, can one achieve an unambiguous estimate of efficiency and its interpretation. It is important that the parameters characterizing the data arrays for which one or another method is tested can also act as basic parameters. On the basis of the equations obtained in the work, by means of the triad of basic parameters, all other parameters are determined, diversifying the efficiency. One of these triads includes sensitivity, specificity and accuracy, which in this combination uniquely determine efficiency. In this paper, from these positions, data of some works of recent years are analyzed.

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Application of the Milan System for Reporting Salivary Gland Cytopathology: Experience of an academic institution in a tertiary academic medical center

Castrodad-Rodríguez

Lajara

Khader

et al. 2020

Cancer Cytopathology

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Background The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) represents a standardized reporting system for salivary gland lesions. The recent literature has demonstrated a wide range of data regarding range of malignancy (ROM) and interobserver variability. The objective of the current study was to evaluate the reproducibility and interobserver agreement of MSRSGC, and establish the ROM in a unique patient population residing within a designated Health Professional Shortage Area. Methods A total of 380 salivary gland fine‐needle aspiration cases were obtained over a 3‐year period. Corresponding cytology reports and slides were reviewed in a blinded fashion by a panel of cytopathologists and recategorized using MSRSGC. ROM was calculated by cytohistologic correlation in 176 cases. Agreement between review of reports and slides and interobserver reliability were determined using kappa statistics. Results The ROMs per MSRSGC category based on review of reports and slides were as follows: 4% and 0%, respectively, for nonneoplastic; 22% and 0%, respectively, for nondiagnostic; 42.9% and 48%, respectively, for atypia of undetermined significance; 1.6% and 1.9%, respectively, for benign‐neoplastic; 17.9% and 15.6%, respectively, for salivary gland neoplasm of uncertain malignant potential; 81.8% and 71.4%, respectively, for suspicious for malignancy; and 100% and 90.5%, respectively, for malignant. There was a 59.2% overall agreement between review of reports and slides with regard to recategorizing salivary gland lesions (kappa, 0.51). The interobserver reliability demonstrated a 64.6% agreement (weighted kappa, 0.59). Conclusions The ROMs at the study institution appeared comparable to those in the published literature. There was moderate overall agreement among cytopathologists and low interobserver agreement with regard to the indeterminate categories. Image‐guided fine‐needle aspiration specimens; rapid onsite adequacy; and integration of clinical, imaging, and ancillary studies can improve diagnostic accuracy among indeterminate lesions.

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The accuracy of fine-needle aspiration cytology for diagnosis of parotid gland masses: a clinicopathological study of 114 patients

Cited by 63 publications

References 30 publications

Cytopathology and diagnostics of Warthin's tumour

Cytopathology and diagnostics of Warthin's tumour

About the Evaluation of the Effectiveness of Various Methods of Diagnosis, Prediction and Classification Presented in the Literature

Application of the Milan System for Reporting Salivary Gland Cytopathology: Experience of an academic institution in a tertiary academic medical center

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