The Accuracy of a Fibromyalgia Diagnosis in General Practice

Gittins, Rosalind; Howard, Molly; Ghodke, Ameer; Ives, Timothy J.; Chelminski, Paul R.

doi:10.1093/pm/pnx155

Cited by 19 publications

(16 citation statements)

References 41 publications

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“…Furthermore, physicians’ skill-related factors (poor communication, age and the knowledge of the ACR diagnostic criteria) contribute to diagnostic inaccuracy 1 , 3 . The lack of a definitive diagnosis of fibromyalgia potentially affect functionality, daily activities and work productivity 5 , 6 . Although the pattern of clinical diagnosis of fibromyalgia continues to improve in terms of accuracy and sensitivity, there is an increasing recognition of both misdiagnosis and overdiagnosis 1 .…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of fibromyalgia can be established by the classification criterion of the American College of Rheumatology (ACR) of 1990 (with the evaluation of tender points) or without the test of tender points by using a modified diagnostic criterion from ACR of 2010 or 2011 4 . In 2010, the ACR published a revised criterion set that does not count the tender points 5 . These criteria include 19 pain sites and 41 somatic symptoms 6 .…”

Section: Introductionmentioning

confidence: 99%

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Spectrochemical analysis in blood plasma combined with subsequent chemometrics for fibromyalgia detection

Passos

Alves

Morais

et al. 2020

Sci Rep

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Fibromyalgia is a rheumatologic condition characterized by multiple and chronic body pain, and other typical symptoms such as intense fatigue, anxiety and depression. It is a very complex disease where treatment is often made by non-medicated alternatives in order to alleviate symptoms and improve the patient’s quality of life. Herein, we propose a method to detect patients with fibromyalgia ( n = 252, 126 controls and 126 patients with fibromyalgia) through the analysis of their blood plasma using attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy in conjunction with chemometric techniques, hence, providing a low-cost, fast and accurate diagnostic approach. Different chemometric algorithms were tested to classify the spectral data; genetic algorithm with linear discriminant analysis (GA-LDA) achieved the best diagnostic results with a sensitivity of 89.5% in an external test set. The GA-LDA model identified 24 spectral wavenumbers responsible for class separation; amongst these, the Amide II (1,545 cm −1 ) and proteins (1,425 cm −1 ) were identified to be discriminant features. These results reinforce the potential of ATR-FTIR spectroscopy with multivariate analysis as a new tool to screen and detect patients with fibromyalgia in a fast, low-cost, non-destructive and minimally invasive fashion.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spectrochemical analysis in blood plasma combined with subsequent chemometrics for fibromyalgia detection

Passos

Alves

Morais

et al. 2020

Sci Rep

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“…HG testing helps better determine muscular strength, and helps serve as a predictor of physical function, morbidity and mortality ( Aparicio, Carbonell, Ortega, Ruiz-Ruiz, Heredia, & Delgado, 2010 ). These materials will also be designed with intention of HCPs to better understand how they might work with their patients to discuss FM and other less recognized men’s health issues with the goal of reducing common misdiagnoses ( Gittins, Howard, Ghodke, Ives, & Chelminski, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Understanding the Impact of Fibromyalgia on Men: Findings From a Nationwide Survey

et al. 2018

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Fibromyalgia (FM) is a serious condition that affects approximately four million people in the United States, and is underdiagnosed in men. The objective of this study was to understand this phenomenon by examining multiple impacts of fibromyalgia on men in regard to interactions in society and the U.S. health system. A qualitative survey was administered to 1,163 respondents both online and in-person in Tennessee, Virginia, Maryland, and Washington, DC. Thematic analyses of the survey responses suggest that men with FM have negative experiences with (1) physical and mental health, (2) quality of life, (3) relationships, and (4) careers as a result of FM. Interactions with health-care providers were deterred by (1) potential for misdiagnosis or dismissal of symptoms, (2) stigma of having a condition primarily affecting women, (3) differences in treatment of men and women with FM, and (4) need for health education resources. These findings dictate a need to improve communication between health-care providers and male FM patients.

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“…Multiple adjustments to the criteria have followed with the most recent revision centered on a combination of pain plus a variety of other symptoms [20,21]. Notwithstanding these changes, many physicians still lack the proper training to diagnose FM [22]. Patients with illdefined symptomatology are grouped into the FM category inappropriately [22].…”

Section: Introductionmentioning

confidence: 99%

The Search for Biomarkers in Fibromyalgia

Hackshaw

2021

Diagnostics

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Fibromyalgia is the most common of the central sensitivity syndromes affecting 2–5% of the adult population in the United States. This pain amplification syndrome has enormous societal impact as measured by work absenteeism, decreased work productivity, disability and injury compensation and over-utilization of healthcare resources. Multiple studies have shown that early diagnosis of this condition can improve patient outlook and redirect valuable healthcare resources towards more appropriate targeted therapy. Efforts have been made towards improving diagnostic accuracy through updated criteria. The search for biomarkers for diagnosis and verification of Fibromyalgia is an ongoing process. Inadequacies with current diagnostic criteria for this condition have fueled these efforts for identification of a reproducible marker that can verify this disease in a highly sensitive, specific and reproducible manner. This review focuses on areas of research for biomarkers in fibromyalgia and suggests that future efforts might benefit from approaches that utilize arrays of biomarkers to identify this disorder that presents with a diverse clinical phenotype.

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The Accuracy of a Fibromyalgia Diagnosis in General Practice

Abstract: FM is commonly misdiagnosed: all patients with a working diagnosis should be reassessed and reviewed to ensure that the most appropriate treatment is provided.

Cited by 19 publications

References 41 publications

Spectrochemical analysis in blood plasma combined with subsequent chemometrics for fibromyalgia detection

Spectrochemical analysis in blood plasma combined with subsequent chemometrics for fibromyalgia detection

Understanding the Impact of Fibromyalgia on Men: Findings From a Nationwide Survey

The Search for Biomarkers in Fibromyalgia

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