Fibromyalgia is a rheumatologic condition characterized by multiple and chronic body pain, and other typical symptoms such as intense fatigue, anxiety and depression. It is a very complex disease where treatment is often made by non-medicated alternatives in order to alleviate symptoms and improve the patient’s quality of life. Herein, we propose a method to detect patients with fibromyalgia ( n = 252, 126 controls and 126 patients with fibromyalgia) through the analysis of their blood plasma using attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy in conjunction with chemometric techniques, hence, providing a low-cost, fast and accurate diagnostic approach. Different chemometric algorithms were tested to classify the spectral data; genetic algorithm with linear discriminant analysis (GA-LDA) achieved the best diagnostic results with a sensitivity of 89.5% in an external test set. The GA-LDA model identified 24 spectral wavenumbers responsible for class separation; amongst these, the Amide II (1,545 cm −1 ) and proteins (1,425 cm −1 ) were identified to be discriminant features. These results reinforce the potential of ATR-FTIR spectroscopy with multivariate analysis as a new tool to screen and detect patients with fibromyalgia in a fast, low-cost, non-destructive and minimally invasive fashion.
Este artigo consiste em apresentar um relato de experiência vivenciada na curadoria realizada no curso FIC – Modalidade Mulheres Mil 2017.2, que teve como tema meio ambiente, voltado à reciclagem, ofertado pelo Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte – IFRN – Campus Avançado Lajes. O objetivo deste trabalho foi mediar a leitura do conto “Amor”, de Clarice Lispector, com as mulheres participantes do curso, trazendo um momento de leitura, interpretação e reflexão do texto, contribuindo para a formação de leitores. O trabalho realizado teve como suporte os pressupostos de Vygotsky (1996), sobre mediação e aprendizagem, além dos pressupostos do Interacionismo Sociodiscursivo sobre o papel da linguagem no desenvolvimento humano ao longo da vida. O trabalho desenvolvido aponta para uma possível tomada de consciência sobre a importância da leitura tanto das estudantes curadoras quanto das estudantes cursistas.
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