The accuracy of 99Molybdenum assays in 99mTechnetium solutions.

Abstract

A study was performed to determine the accuracy of 99Mo measurements using three commercial dose calibrators with their 99Mo assay shields. One 99Mo assay shield allowed excessive penetration by the lower energy 99mtc photons, resulting in the calibrator's falsely high interpretation of the activity of 99Mo present in the high-activity 99mTc eluates. All three calibrators performed adequately with a National Bureau of Standards 99Mo standard in equilibrum with 99mTc. By using low-activity aliquots of 99Mo and 99mTc, a low-level linearity test was performed. Two of the calibrators were found to have a threshold of approximately 10 microCi (370 kBq) for a nonzero 99Mo response, although one of these occasionally produced variable nonzero responses below its threshold. Only one of the calibrators was found to reflect accurately the activity of 99Mo present under all conditions tested.

Alguns aspectos sobre geradores e radiofármacos de tecnécio-99m e seus controles de qualidade

“…Para garantir a adequada realização do controle de qualidade do eluato do gerador, deve-se ter certeza que o calibrador de dose utilizado na determinação da eficiência de eluição e da pureza radionuclídica ( 99 Mo) esteja respondendo adequadamente à quantificação dos radioisótopos (73) , uma vez que esta quantificação deve ser absoluta e não relativa, como ocorre na determinação da pureza radioquímica que é feita por medidas comparativas. A utilização de recursos da informática para processamento e registro dos dados dos controles realizados pode facilitar o trabalho diário (74) .…”

Fission 99Mo/99mTc Generators – A Study of their Quality

“…The technical construction of the generators has much improved lately so that their operation has become safe and simple. Despite this state of development, the user of generators is confronted with problems which have to be considered (9,14,16,21,22,24).…”

The presentation of clinical results of radiolabelling of 99mTc-MIBI complex using ultrasound technique for myocardial perfusion SPECT scanning

“…The lyophilized products were provided applying the fresh Na + -99m TcO 4 − solution (740-3700 MBq = 20-100 mCi)) from generators eluted in sterile conditions. In 99 Mo/ 99m Tc generators, regarding the imperfections in producing the generator or possible occurrence of mechanical defects, 99 Mo may leak from the generator due to the elution process [14][15][16]. To resolve the contents of vial, the protected vial should be strenuously shaken due to safety conditions.…”