The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity

Díaz-Gimeno, Patricia; Ruiz-Alonso, María; Blesa, David; Bosch, Núria Ferrer; Martínez-Conejero, José Antonio; Alamá, Pilar; Garrido, Nicolás; Pellicer, António; Simón, Carlos

doi:10.1016/j.fertnstert.2012.09.046

Cited by 249 publications

(149 citation statements)

References 47 publications

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“…However it is agreed that histological changes may not truly reflect functional endometrial changes and hopefully novel tests may be on the horizon to predict the receptive state of the uterus after follicular stimulation (and perhaps natural cycles?) [34]. Furthermore in our current study pregnancies were established within a wide range of E 2 levels, with low levels of 177 ng/mL (known to support receptivity) but also with high levels >2000 pg/mL, challenging the concept that "unphysiological moderate" hyperstrogenism can affect implantation.…”

Section: Discussionmentioning

confidence: 57%

Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement

Bocca

Real

Lynch

et al. 2015

J Assist Reprod Genet

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Purpose To investigate the impact of late follicular phase serum estradiol (E 2 ) levels on implantation and pregnancy outcomes of cleavage stage cryopreserved/thawed embryos transferred in programmed cycles with exogenous hormonal replacement. Methods Retrospective cohort analysis of IVF patients with transfer of cryopreserved-thawed day-3 embryos in E 2 and progesterone (P4) supplemented cycles (n=208 cycles). Main outcome measures: implantation and pregnancy rates according to late follicular phase serum E 2 levels and early secretory phase E 2 /P4 ratios. Results Logistic regression performed for embryo implantation and for pregnancy outcome in relation to E 2 (day 15), P4 (day 15 and 16), before (crude analysis) and after adjustment (adjusted analysis) for baseline characteristics (including age, BMI, serum basal cycle day 3 FSH levels, embryo quality, endometrial lining thickness) showed no significant association. Similarly, ROC analysis showed no impact of cycle day 16 E 2 /P4 ratio. Conclusions Neither late follicular phase serum E 2 nor the early E 2 /P4 ratio were able to predict implantation or pregnancy outcome of day-3 cryopreserved-thawed embryos transferred in artificially programmed cycles.

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Section: Discussionmentioning

confidence: 57%

Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement

Bocca

Real

Lynch

et al. 2015

J Assist Reprod Genet

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show abstract

“…The development of microarray technology [92] helped to analyze the expression of thousands of genes at the same time in an endometrial sample of development in the peri-implantation period. On those grounds, and consistent with the findings that endometrial receptivity may be related to its transcriptomic profile, molecular assessment of endometrial receptivity has been developed [93,94], a molecular diagnostic tool that contains 238 expressed genes coupled to a computational predictor, which is able to identify endometrial samples within the window of implantation, independent of their histological appearance. The endometrial receptivity array (ERA) test may help to identify patients with implantation failure caused by a nonreceptive endometrium, improving the ability to control the endometrial environment for implantation.…”

Section: Abnormal Endometrial Receptivitymentioning

confidence: 86%

Potential Etiologies of Unexplained Infertility in Females

Galliano

Pellicer

2015

Unexplained Infertility

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“…The limitations of the histological dating are confirmed once again in the comparison with the ERA [63], changing the point of view and initiating a transformation from the anatomic to molecular medicine. Our group compared the endometrial dating according to the histologic features (Noyes criteria) between two pathologists and the ERA predictor in samples from oocyte donors.…”

Section: Molecular Approachesmentioning

confidence: 94%

“…The ERA test is included in the clinical protocol of implantation failure in our group as it has been proven an accurate method to discriminate among patients with receptive and nonreceptive endometrium on day LH + 7, or after 5 days of progesterone in a programmed cycle [63]. Nevertheless in terms of implantation, the clinical relevance of this molecular tool for endometrial receptivity has not been yet elucidated in randomized controlled trials.…”

Section: Molecular Approachesmentioning

confidence: 99%