The absorption behavior of cyclosporin A lecithin vesicles in rat intestinal tissue

Chen, Ying; Ping, Qineng; Guo, Zhixiong; Lv, Wenli; Gao, Jing

doi:10.1016/s0378-5173(03)00274-6

Cited by 20 publications

(8 citation statements)

References 9 publications

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“…Formulators have also tried complexation with a soluble adjuvant, or the co-administration of a thermonutrient such as piperine. It has been reported that P-gp inhibitors can significantly increase the absorption of lecithin vesicles of cyclosporine A in the rat small intestine (Chen, Ping, Guo, Lv, & Gao, 2003). Thus, intestinal P-gp inhibition by GFJ may offer further improved absorption of lecithin vesicles of CoQ10.…”

Section: Resultsmentioning

confidence: 97%

Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2

et al. 2010

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Section: Resultsmentioning

confidence: 97%

Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2

et al. 2010

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“…In a second study (11), the absorption behavior of CyA/lecithin vesicles was studied in rat intestinal tissue using everted gut sacs and an in situ circulation method. Most of the vesicles accumulated in the mucus before it reached the intestinal tissue, but there was no significant difference in the accumulated absorption content in the incubating medium and the sacs of Sandimmun-Neoral®-and-CyA containing vesicles.…”

Section: Oral Liposomesmentioning

confidence: 99%

Phospholipids and Lipid-Based Formulations in Oral Drug Delivery

Kromp²,

et al. 2010

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Phospholipids become increasingly important as formulation excipients and as active ingredients per se. The present article summarizes particular features of commonly used phospholipids and their application spectrum within oral drug formulation and elucidates current strategies to improve bioavailability and disposition of orally administered drugs. Advantages of phospholipids formulations not only comprise enhanced bioavailability of drugs with low aqueous solubility or low membrane penetration potential, but also improvement or alteration of uptake and release of drugs, protection of sensitive active agents from degradation in the gastrointestinal tract, reduction of gastrointestinal side effects of non-steroidal anti-inflammatory drugs and even masking of bitter taste of orally applied drugs. Technological strategies to achieve these effects are highly diverse and offer various possibilities of liquid, semi-liquid and solid lipid-based formulations for drug delivery optimization.

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“…32 It was shown that most of the cyclosporin A-loaded liposomes were stranded in the rat intestinal mucus and unable to reach the intestinal wall. In our study, modification of liposomes with PF127 significantly enhanced diffusion efficiency through the native rat intestinal mucus.…”

Section: Mucus-penetrating Properties Of Pf127-modified Liposomesmentioning

confidence: 99%

Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake

Xiuying¹,

Chen²,

Le³

et al. 2011

IJN

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Background The aim of this study was to investigate the intestinal mucus-penetrating properties and intestinal cellular uptake of two types of liposomes modified by Pluronic F127 (PF127). Methods The two types of liposomes, ie, PF127-inlaid liposomes and PF127-adsorbed liposomes, were prepared by a thin-film hydration method followed by extrusion, in which coumarin 6 was loaded as a fluorescence marker. A modified Franz diffusion cell mounted with the intestinal mucus of rats was used to study the diffusion characteristics of the two types of PF127 liposomes. Cell uptake studies were conducted in Caco-2 cells and analyzed using confocal laser scanning microcopy as well as flow cytometry. Results The diffusion efficiency of the two types of PF127-modified liposomes through intestinal rat mucus was 5–7-fold higher than that of unmodified liposomes. Compared with unmodified liposomes, PF127-inlaid liposomes showed significantly higher cellular uptake of courmarin 6. PF127-adsorbed liposomes showed a lower cellular uptake. Moreover, and interestingly, the two types of PF127-modified liposomes showed different cellular uptake mechanisms in Caco-2 cells. Conclusion PF127-inlaid liposomes with improved intestinal mucus-penetrating ability and enhanced cellular uptake might be a potential carrier candidate for oral drug delivery.

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The absorption behavior of cyclosporin A lecithin vesicles in rat intestinal tissue

Cited by 20 publications

References 9 publications

Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2

Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2

Phospholipids and Lipid-Based Formulations in Oral Drug Delivery

Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake

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