The abnormal reward network associated with insomnia severity and depression in chronic insomnia disorder

Gong, Liang; Yu, Siyi; Xu, Rongbin; Liu, Duan; Dai, Xuesong; Wang, Zhengyan; Hu, Youping; Yan, Bohua; Yu, Kyeong-Nam; Zhang, Bei; Feng, Fen

doi:10.1007/s11682-020-00310-w

Cited by 33 publications

(27 citation statements)

References 59 publications

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“…Recently, it was found that depression may be related to the dysfunction of a network of structures that regulate REM sleep, such as the limbic system, including the hippocampus, amygdala, and medial pre-frontal cortex. The reward network is dysfunctional and associated with depression symptoms in patients with chronic insomnia disorder ( 31 ). Furthermore, the subregions of the medial pre-frontal cortex (mPFC) show great changes in neural activity in depressed patients ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

REM Sleep Fragmentation in Patients With Short-Term Insomnia Is Associated With Higher BDI Scores

Tong

et al. 2021

Front. Psychiatry

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Objective: To observe the changes in sleep characteristics and BDI scores in patients with short-term insomnia disorder (SID) using a longitudinal observational study.Methods: Fifty-four patients who met the criteria for SID of the International Classification of Sleep Disorders, third edition, were recruited. Depression levels were assessed using the Beck depression inventory (BDI) at enrollment and after 3 months of follow-up, respectively. Sleep characteristics were assessed by polysomnography.Results: After 3 months of follow-up, the group was divided into SID with increased BDI score (BDI >15) and SID with normal BDI score (BDI ≤ 15) according to the total BDI score of the second assessment. The differences in rapid eye movement (REM) sleep latency, REM sleep arousal index, and NREM sleep arousal index between the two groups were statistically significant. The total BDI score was positively correlated with REM and NREM sleep arousal index and negatively correlated with REM sleep latency, which were analyzed by Pearson correlation coefficient. Multiple linear regression was used to construct a regression model to predict the risk of depression in which the prediction accuracy reached 83.7%.Conclusion: REM sleep fragmentation is closely associated with future depressive status in patients with SID and is expected to become an index of estimating depression risk.

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Section: Discussionmentioning

confidence: 99%

REM Sleep Fragmentation in Patients With Short-Term Insomnia Is Associated With Higher BDI Scores

Tong

et al. 2021

Front. Psychiatry

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“…Recently, many researchers utilized MRI techniques to examine the neural mechanisms for the associations between sleep and MD and found that the altered function and structure of some brain regions (13)(14)(15)(16)(17) and networks (18)(19)(20) may serve as the potential neuroimaging biomarkers. Our previous studies tested brain differences between MDs with low and normal sleep efficiency, and further explored associations between sleep efficiency, brain structural and functional alterations, and clinical variables using multi-modal MRI (21,22).…”

Section: Introductionmentioning

confidence: 99%

The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression

Zhang

2022

Front. Psychiatry

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BackgroundPoor sleep quality is related to depression. However, the investigation of the neural basis for poor sleep quality in individuals with major depression (MD) is limited.MethodsResting state functional and structural MRI data were derived from 114 MD individuals and 74 normal controls (NCs). Fractional amplitude of low-frequency fluctuation (fALFF) and gray matter volume (GMV) were used to measure function and structure of the brain. Pittsburgh Sleep Quality Index (PSQI) was performed to evaluate subjective sleep quality. Correlations were carried out to investigate links of PSQI score with brain imaging indices in MD and NCs, separately. We also examined the differences in fALFF and GMV of brain regions related to PSQI score between MD and NCs.ResultsIn contrast to NCs, MD individuals had higher PSQI score. The higher PSQI score was associated with lower fALFF and lower GMV in bilateral precuneus in MD individuals. Moreover, the MD individuals exhibited increased fALFF in bilateral precuneus compared with NCs. However, the correlation between subjective sleep quality and neuroimaging parameters was not significant in NCs.ConclusionThe implication of these findings is that the function and structure of precuneus provides a neural basis for subjective poor sleep quality in MD. Understanding this may lead to better intervention of depression and associated sleep complaints.

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“…Numerous groups have used various neuroimaging approaches and demonstrated specific brain structural and functional alterations in patients with CID (Huang et al, 2012;Joo et al, 2013;Li et al, 2018;Yu et al, 2018a,b;Gong et al, 2020c). However, these studies have yielded diverse findings, e.g., the altered brain structural regions included orbitofrontal cortex, hippocampus, amygdala, precuneus, and anterior cingulate cortex (ACC) (Altena et al, 2010;Winkelman et al, 2013), while the abnormal functional networks included default mode network, salience network, frontostriatal network, and reward networks (Chen et al, 2014;Huang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The Abnormal Functional Connectivity in the Locus Coeruleus-Norepinephrine System Associated With Anxiety Symptom in Chronic Insomnia Disorder

et al. 2021

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BackgroundMental syndromes such as anxiety and depression are common comorbidities in patients with chronic insomnia disorder (CID). The locus coeruleus noradrenergic (LC-NE) system is considered to be crucial for modulation of emotion and sleep/wake cycle. LC-NE system is also a critical mediator of the stress-induced anxiety. However, whether the LC-NE system contributes to the underlying mechanism linking insomnia and these comorbidities remain unclear. This study aimed to investigate the LC-NE system alterations in patients with insomnia and its relationship with depression and anxiety symptoms.Materials and MethodsSeventy patients with CID and 63 matched good sleep control (GSC) subjects were recruited and underwent resting-state functional MRI scan. LC-NE functional network was constructed by using seed-based functional connectivity (FC) analysis. The alterations in LC-NE FC network in patients with CID and their clinical significance was explored.ResultsCompared with GSC group, the CID group showed decreased left LC-NE FC in the left inferior frontal gyrus, while they had increased LC-NE FC in the left supramarginal gyrus and the left middle occipital gyrus (MOG). For the right LC-NE FC network, decreased FC was found in left dorsal anterior cingulate cortex (dACC). Interesting, the increased LC-NE FC was located in sensory cortex, while decreased LC-NE FC was located in frontal control cortex. In addition, the FC between the left LC and left MOG was associated with the duration of the disease, while abnormal FC between right LC and left dACC was associated with the anxiety scores in patients with CID.ConclusionThe present study found abnormal LC-NE functional network in patients with CID, and the altered LC-NE function in dACC was associated with anxiety symptoms in CID. The present study substantially extended our understanding of the neuropathological basis of CID and provided the potential treatment target for CID patients who also had anxiety.

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The abnormal reward network associated with insomnia severity and depression in chronic insomnia disorder

Cited by 33 publications

References 59 publications

REM Sleep Fragmentation in Patients With Short-Term Insomnia Is Associated With Higher BDI Scores

REM Sleep Fragmentation in Patients With Short-Term Insomnia Is Associated With Higher BDI Scores

The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression

The Abnormal Functional Connectivity in the Locus Coeruleus-Norepinephrine System Associated With Anxiety Symptom in Chronic Insomnia Disorder

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