The Ability to Regenerate the Liver in Experimental Animals with Induced Cirrhosis under the Influence of the Spatially Modulated Erbium Laser

Пикиреня, И. И.; Zemlyanik, А.N.; Khomchenko, V.V.

doi:10.18484/2305-0047.2015.2.131

Cited by 6 publications

(1 citation statement)

References 2 publications

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“…Se puede establecer así un paralelismo con lo que hemos observado en el caso de las úlceras crónicas del presente estudio, donde tampoco vimos efecto térmico del láser al aplicar la tecnología RecoSMA. Justamente esta observación se llevó a cabo en los primeros ensayos clínicos sobre tratamientos de úlceras crónicas (16,17). El mecanismo de estimulación de la reparación tisular con láser de Er:YAG y la tecnología RecoSMA fue descubierto de forma fortuita, durante experimentos realizados en modelos de hígados cirróticos de ratas blancas.…”

Section: Discussionunclassified

Tratamiento de las úlceras crónicas de las piernas con láser de Er: YAG y tecnología RecoSMA

Hernández

Khomchenko²,

Sola³

et al. 2015

Cir. plást. iberolatinoam.

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ResumenLas úlceras crónicas de los miembros inferiores (UCMI) tienen una elevada prevalencia, etiología diversa y son de difícil curación. El objetivo del presente estudio es evaluar los resultados alcanzados en su curación mediante el empleo de un láser de Erbium:YAG con tecnología RecoSMA. Este láser y sistema de tecnología emite energía en forma de miles de microhaces induciendo microablación de la epidermis y actuación en las células de la dermis por efecto mecánico-acústico.Tratamos con irradiación semanal 17 pacientes durante 3 meses. La evaluación de resultados se realizó mediante cuestionarios y correlación clínica e histológica, realizando fotografías antes de cada sesión de tratamiento (12 en total), y su correspondiente análisis con asistencia de un programa informático.Los resultados mostraron curación completa, o reducción del área de las úlceras en aproximadamente el 50% de su superficie inicial en más del 50% de los pacientes. En el estudio estadístico empleamos t de Student y test exacto de Fisher y obtuvimos resultados estadísticamente significativos, con p<0,05.El láser de Er:YAG y la tecnología RecoSMA basada en ópticas que convierten el haz del láser en miles de microhaces no solamente se absorbe en la superficie del tejido, sino que penetra en la dermis y, por mecanismo mecánico-acústico, produce efectos de resonancia eficaces para producir regeneración tisular. Su empleo en las UCMI de difícil solución es una alternativa de tratamiento eficaz y seguro.Palabras clave Úlceras, Ulceras crónicas miembros inferiores, Láser Erbium,YAG, Tecnología RecoSMA. Nivel de evidencia científica 4 AbstractChronic lower extremity ulcers (CLEU) have a high prevalence, present various aetiologies and are difficult to heal. The aim of the present study is to evaluate the results achieved in healing CLEU using an Erbium:YAG with RecoSMA technology. This laser emits energy in thousands of microbeams causing superficial epidermal ablation by thermal effect, and a limited cell membrane destruction in dermis due to a mechanical-acoustic effect.Evaluation of results achieved was carried out in 17 patients enrolled in the study by questionnaires, histologies and clinical visual correlation of progress by photographs taken before each session (12 session in total), which were analyzed with the help of a computer program.Results after 12 treatment sessions showed complete healing of ulcers or a decrease of their initial area in at least 50% in more than 50% of patients treated. The t Student test and Fishers´ exact test were used for the statistical analysis noticing that results obtained were statistically significant with p<0,05.The Er:YAG laser and RecoSMA technology, based on a system of optics which converts the laser beam in thousands of microbeams, it is not only absorbed in the tissue surface, but penetrates in the dermis. The acoustic-mechanical mechanism produces effective resonance effects to achieve tissue regeneration. This technology used on difficult CLEU offers an effective and safe treatment alternative.

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Section: Discussionunclassified

Tratamiento de las úlceras crónicas de las piernas con láser de Er: YAG y tecnología RecoSMA

Hernández

Khomchenko²,

Sola³

et al. 2015

Cir. plást. iberolatinoam.

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Spatially modulated erbium YAG laser as a treatment for diabetic ulcer

Chilgar,

Andurkar

2023

J Wound Care

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Objective: Diabetic ulcers are a significant healthcare challenge, capable of diminishing quality of life, lengthening hospitalisation stay, and incurring substantial costs for patients and healthcare systems. Erbium-doped yttrium-aluminum-garnet (Er-YAG) laser has been evolving as a prospective intervention for addressing wounds of various aetiologies. Despite this, the literature remains limited in appraising the effectiveness of laser therapy specifically in diabetic wounds. This study investigates the impact of employing a spatially modulated Er-YAG laser as a therapeutic approach for treating diabetic ulcers. Method: In a single-arm study conducted from November 2017 to April 2023, patients with hard-to-heal ulcers were treated in a two-step approach of wound debridement using Er-YAG laser for ablation and biostimulation through deep tissue resonance using RecoSMA (Multiline laser system, LINLINE MS, Latvia) laser technology. Ulcers received weekly laser treatment, together with routine care until healing occurred and were then followed up to observe any recurrence. The primary outcome measure was wound closure; the secondary outcome measures were time to closure, and the number of laser treatments required. Data related to sociodemographic details, size and number of diabetic ulcers, and number of sessions related to laser treatment were collected using a predesigned, pretested questionnaire before initiating the treatment. Results: A total of 59 patients attending the clinic during the study period with diabetic ulcers were included in the study. The mean wound surface area at baseline was 25.7cm2 (median: 12cm2). The average number of sessions of laser treatment required was 4.41, ranging from 1–11. The size of the ulcer reduced with each session of laser treatment. The diabetic ulcers healed completely at the end of the treatment, indicating the effectiveness of the Er-YAG/RecoSMA two-step approach. Conclusion: Spatially modulated erbium YAG laser is effective as a therapeutic approach for treating diabetic ulcers.

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Stimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)

Vesir

Dambayev

Gunter³

et al. 2020

Acta biomedica scientifica

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Currently, morbidity and mortality from chronic diffuse diseases of the liver and cirrhosis continue to increase worldwide. The difficulty of stabilizing the process with pharmacological agents, lots of restrictions for liver transplantation, the palliative character of the surgical correction of complications determine the urgency of finding various ways to stimulate liver regeneration, including surgical ones. Most of the known methods of surgical stimulation of regeneration are quite traumatic, and their stimulating effect is short-lived. The methods associated with cellular technologies are mostly expensive, ineffective, or poorly understood. In the experimental study, the effect on the parenchyma of a healthy and cirrhotic liver clips for clamping parenchymal organs exerting different unit pressure on the tissue was studied. The object of the study was laboratory rats with a healthy liver and animals with simulated cirrhosis. The animals were operated on with the imposition of titanium nickelide clips on the liver. Changes in the liver were studied 3, 7, 14, and 28 days after the surgery by histological examination of various parts of the liver. It was established that the clip with a lower specific pressure did not cause tissue necrosis, led to atrophy of the marginal part of the liver, also increased hepatocytes and binuclear hepatocytes were observed in the bulk of the liver. A decrease in the proportion of connective tissue was also observed in groups with liver cirrhosis. Thus, we consider it possible to use clips with a certain specific pressure on the tissue as a method of stimulating the reparative properties of the liver in chronic diffuse diseases and cirrhosis of the liver

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The Ability to Regenerate the Liver in Experimental Animals with Induced Cirrhosis under the Influence of the Spatially Modulated Erbium Laser

Cited by 6 publications

References 2 publications

Tratamiento de las úlceras crónicas de las piernas con láser de Er: YAG y tecnología RecoSMA

Tratamiento de las úlceras crónicas de las piernas con láser de Er: YAG y tecnología RecoSMA

Spatially modulated erbium YAG laser as a treatment for diabetic ulcer

Stimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)

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