The ability of a topical novel combination of fipronil, amitraz and (S)-methoprene to protect dogs from Borrelia burgdorferi and Anaplasma phagocytophilum infections transmitted by Ixodes scapularis

McCall, John W.; Baker, Christine; Mather, Thomas N.; Chester, S. Theodore; McCall, Scott; Irwin, Jennifer; Young, Stephanie L.; Cramer, Luiz G.; Pollmeier, Matthias

doi:10.1016/j.vetpar.2011.03.046

Cited by 31 publications

(16 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…63 Preventive products for individual dogs are widely available and well-established in their ability to decrease the degree of ectoparasite exposure and thereby prevent the transmission of infectious diseases by these vectors, including RMSF, 47 leishmaniasis, 64 ehrlichiosis, 65,66 anaplasmosis, and borreliosis. 67 Additionally, parasites such as mites (Cheyletiella spp, Otodectes cyanotis, and Sarcoptes scabiei), although not known to spread pathogens infectious to dogs, are themselves transmissible, most notably in group settings. 7 Fleas are the most common ectoparasites of dogs.…”

Section: Vector Control and Vector-borne Disease Preventionmentioning

confidence: 99%

Risk reduction and management strategies to prevent transmission of infectious disease among dogs at dog shows, sporting events, and other canine group settings

Stull¹,

Kasten²,

Evason³

et al. 2016

javma

View full text Add to dashboard Cite

Section: Vector Control and Vector-borne Disease Preventionmentioning

confidence: 99%

Risk reduction and management strategies to prevent transmission of infectious disease among dogs at dog shows, sporting events, and other canine group settings

Stull¹,

Kasten²,

Evason³

et al. 2016

javma

View full text Add to dashboard Cite

“…It can be assumed that the risk of pathogen transmission from arthropods to their hosts may be significantly decreased if fleas or ticks are killed quickly enough (in <24 h) and if this speed of kill is sustained during a long period of time (>1 month [2]). Several authors have studied the indirect preventive role of insecticidal and/or acaricidal treatments against the transmission of flea or tick-borne diseases [7, 16–18, 20]. However, essentially all of the flea or tick transmitted pathogens studied were bacteria or protozoa: Ehrlichia canis , Anaplasma phagocytophilum , Borrelia burgdorferi , B. henselae .…”

Section: Introductionmentioning

confidence: 99%

Preventive efficacy of Frontline^®Combo and Certifect^®againstDipylidium caninuminfestation of cats and dogs using a natural flea (Ctenocephalides felis) infestation model

Beugnet¹,

Delport

Luus

et al. 2013

Parasite

View full text Add to dashboard Cite

Two studies were performed to evaluate the effectiveness of two monthly topical anti-flea products for the prevention of Dipylidium caninum infestations in cats and dogs. A single treatment with Frontline® Combo spot-on for cats (fipronil-(S)-methoprene) and two successive monthly treatments of Certifect® for dogs (fipronil-amitraz-(S)-methoprene) were assessed for the prevention of D. caninum infestations following weekly challenges of treated cats or dogs with metacestode naturally-infected fleas. The rate of infestations using the model in cats versus dogs explains the choice of a 1-month trial in cats and a 2-month trial in dogs. The experimental flea-infection model resulted in a range of 22–53% of the fleas being infected by Dipylidium cysticercoids. The arithmetic mean flea counts recorded for the untreated cats ranged from 51.2 to 68. The geometric mean flea counts recorded for the Frontline Combo treated cats differed significantly (p < 0.05) from those of the untreated control cats on all assessment days. The arithmetic mean flea counts recorded for the untreated dogs ranged from 166.6 to 238.6. The geometric mean flea counts recorded for the Certifect treated dogs differed significantly (p < 0.001) from those of the untreated group on all assessment days. Frontline Combo treatment on cats provided ≥99.8% persistent anti-flea efficacy throughout the 30-day treatment period. In the dog study, the two Certifect treatments provided ≥97% persistent efficacy throughout the 60-day study. Based on the collection of expelled D. caninum proglottids by cats, 100% (6/6) of the control cats and 0% (0/6) of Frontline Combo treated cats were infested with D. caninum. Frontline Combo spot-on for cats was therefore 100% effective in preventing infection with D. caninum. In dogs, 7 out of the 8 control group dogs (87.5%) produced proglottids following infestation of infected fleas, whereas 0 out of 8 dogs (0%) in the treated group were infected. The infection rates of the two groups were significantly different. The percent effectiveness for the Certifect treatment group for the prevention of D. caninum infection was 100% during this 2-month trial. No treatment-related adverse events were observed in either cats or dogs during these studies.

show abstract

“…However, these studies were conducted under laboratory conditions; all existing variables of the vector: host natural state (e.g., vector infection rate and pressure, interrupted tick feeding, variations in the age, breed, and immune status of the host, and presence of other reservoir hosts) cannot be replicated in a laboratory. More importantly, in several studies conducted in dogs the use of commercial acaricidal products protected from an A. phagocytophilum or E. canis infection [8,[23][24][25][26][27]. These products are described as having a slower speed of kill (i.e., time needed after treatment/ re-infestation to kill >90% of attached ticks) compared with fluralaner [23,[28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

The speed of kill of fluralaner (Bravecto¿) against Ixodes ricinus ticks on dogs

Wengenmayer¹,

Williams²,

Zschiesche³

et al. 2014

Parasites & Vectors

View full text Add to dashboard Cite

Background: Pathogens that are transmitted by ticks to dogs, such as Anaplasma phagocytophilum, Babesia spp., Borrelia burgdorferi sensu latu, and Ehrlichia canis, are an increasing problem in the world. One method to prevent pathogen transmission to dogs is to kill the ticks before transmission occurs. Fluralaner (Bravecto™) is a novel isoxazoline insecticide and acaricide that provides long persistent antiparasitic activity following systemic administration. This study investigated the speed of kill of fluralaner against Ixodes ricinus ticks on dogs.

show abstract

The ability of a topical novel combination of fipronil, amitraz and (S)-methoprene to protect dogs from Borrelia burgdorferi and Anaplasma phagocytophilum infections transmitted by Ixodes scapularis

Cited by 31 publications

References 23 publications

Risk reduction and management strategies to prevent transmission of infectious disease among dogs at dog shows, sporting events, and other canine group settings

Risk reduction and management strategies to prevent transmission of infectious disease among dogs at dog shows, sporting events, and other canine group settings

Preventive efficacy of Frontline^®Combo and Certifect^®againstDipylidium caninuminfestation of cats and dogs using a natural flea (Ctenocephalides felis) infestation model

The speed of kill of fluralaner (Bravecto¿) against Ixodes ricinus ticks on dogs

Contact Info

Product

Resources

About

The ability of a topical novel combination of fipronil, amitraz and (S)-methoprene to protect dogs from Borrelia burgdorferi and Anaplasma phagocytophilum infections transmitted by Ixodes scapularis

Cited by 31 publications

References 23 publications

Risk reduction and management strategies to prevent transmission of infectious disease among dogs at dog shows, sporting events, and other canine group settings

Risk reduction and management strategies to prevent transmission of infectious disease among dogs at dog shows, sporting events, and other canine group settings

Preventive efficacy of Frontline®Combo and Certifect®againstDipylidium caninuminfestation of cats and dogs using a natural flea (Ctenocephalides felis) infestation model

The speed of kill of fluralaner (Bravecto¿) against Ixodes ricinus ticks on dogs

Contact Info

Product

Resources

About

Preventive efficacy of Frontline^®Combo and Certifect^®againstDipylidium caninuminfestation of cats and dogs using a natural flea (Ctenocephalides felis) infestation model