The A-S-C-O classification identifies cardioembolic phenotypes in a high proportion of embolic stroke of undetermined source (ESUS)

Montero, Marta Vales; Pastor, A. García; Cano, Beatriz Chavarria; García, P. Sobrino; Mohedano, Ana Iglesias; Otero, Francisco Javier Sanjiao; Alén, P. Vázquez; Buzo, E. Luque; Cámara, Paula Salgado; Campo, Paula; Gómez, Miguel Ángel Martín; Bullido, Y. Fernández; Osorio, José; Núñez, A. Gil

doi:10.1016/j.jns.2016.05.029

Cited by 11 publications

(6 citation statements)

References 4 publications

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“…The study population encompasses a wide spectrum of patients across multiple continents. Moreover, the population is similar to published smaller cohorts of patients with cryptogenic stroke or ESUS, 2,12–15 supporting the external validity and generalizability of the ESUS concept and its implementation in this trial.…”

Section: Discussionsupporting

confidence: 75%

Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial

Kasner

Lavados

Sharma

et al. 2018

Journal of Stroke and Cerebrovascular Diseases

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Section: Discussionsupporting

confidence: 75%

Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial

Kasner

Lavados

Sharma

et al. 2018

Journal of Stroke and Cerebrovascular Diseases

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“…We pooled the data of all consecutive patients with ESUS from 11 prospective stroke registries. Three registries were used as the derivation cohort (Athens and Larissa [Greece] and Lausanne [Switzerland] [7][8][9] ) and 8 registries were used as the external validation cohort (Buenos Aires [Argentina], San José [Costa Rica], Helsinki [Finland], Perugia [Italy], Mexico city [Mexico], Barcelona and Madrid [Spain] [10][11][12][13][14][15][16][17] ). Prospectively, data from all centers were collected with the use of a standardized form with prespecified measures.…”

Section: Methodsmentioning

confidence: 99%

A tool to identify patients with embolic stroke of undetermined source at high recurrence risk

Ntaios

Georgiopoulos²,

Perlepe³

et al. 2019

Neurology

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ObjectiveA tool to stratify the risk of stroke recurrence in patients with embolic stroke of undetermined source (ESUS) could be useful in research and clinical practice. We aimed to determine whether a score can be developed and externally validated for the identification of patients with ESUS at high risk for stroke recurrence.MethodsWe pooled the data of all consecutive patients with ESUS from 11 prospective stroke registries. We performed multivariable Cox regression analysis to identify predictors of stroke recurrence. Based on the coefficient of each covariate of the fitted multivariable model, we generated an integer-based point scoring system. We validated the score externally assessing its discrimination and calibration.ResultsIn 3 registries (884 patients) that were used as the derivation cohort, age, leukoaraiosis, and multiterritorial infarct were identified as independent predictors of stroke recurrence and were included in the final score, which assigns 1 point per every decade after 35 years of age, 2 points for leukoaraiosis, and 3 points for multiterritorial infarcts (acute or old nonlacunar). The rate of stroke recurrence was 2.1 per 100 patient-years (95% confidence interval [CI] 1.44–3.06) in patients with a score of 0–4 (low risk), 3.74 (95% CI 2.77–5.04) in patients with a score of 5–6 (intermediate risk), and 8.23 (95% CI 5.99–11.3) in patients with a score of 7–12 (high risk). Compared to low-risk patients, the risk of stroke recurrence was significantly higher in intermediate-risk (hazard ratio [HR] 1.78, 95% CI 1.1–2.88) and high-risk patients (HR 4.67, 95% CI 2.83–7.7). The score was well-calibrated in both derivation and external validation cohorts (8 registries, 820 patients) (Hosmer-Lemeshow test χ2: 12.1 [p = 0.357] and χ2: 21.7 [p = 0.753], respectively). The area under the curve of the score was 0.63 (95% CI 0.58–0.68) and 0.60 (95% CI 0.54–0.66), respectively.ConclusionsThe proposed score can assist in the identification of patients with ESUS at high risk for stroke recurrence.

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“…МКБ-11 состоит из 26 глав, пронумерованных арабскими цифрами (вместо римских -в МКБ-10), и содержит коды заболеваний, состояний, связанных со здоровьем, и внешних причин заболеваний или смерти. Необходимо обратить внимание, что коды с 1-й по 9-ю главы начинаются с цифры, соответствующей номеру главы (1)(2)(3)(4)(5)(6)(7)(8)(9), коды последующих глав (10-26) начинаются с латинской буквы в алфавитном порядке (А-S).…”

Section: транзиторная ишемическая атака и ишемический инсульт в междуunclassified

Транзиторна Ішемічна Атака Й Ішемічний Інсульт У Міжнародній Класифікації Хвороб 11-Го Перегляду

Sorokin¹

2021

INJ

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У статті наведено аналіз розділу 8B0–8B2 «Цереброваскулярні хвороби» Міжнародної класифікації хвороб 11-го перегляду, яка офіційно вступить в силу у 2022 році. Діагнози транзиторної ішемічної атаки і церебрального ішемічного інсульту можуть кодуватися в блоках «Церебральна ішемія» (8B10, 8B11, 8B1Y, 8B1Z), 8B22 «Деякі уточненi цереброваскулярні захворювання» і 8B23 «Цереброваскулярні розлади». При відповідності стану пацієнта критеріям інсульту і неможливості уточнення типу інсульту за допомогою нейровізуалізації або інших методів обстеження може використовуватися код 8B20 «Інсульт, що не уточнений як ішемічний або геморагічний». Коди блока 8B25 «Наслідки цереброваскулярного захворювання» повинні застосовуватися через 1 місяць чи пізніше після початку цереброваскулярного захворювання.

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The A-S-C-O classification identifies cardioembolic phenotypes in a high proportion of embolic stroke of undetermined source (ESUS)

Cited by 11 publications

References 4 publications

Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial

Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial

A tool to identify patients with embolic stroke of undetermined source at high recurrence risk

Транзиторна Ішемічна Атака Й Ішемічний Інсульт У Міжнародній Класифікації Хвороб 11-Го Перегляду

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