The 57Fe hyperfine interactions in the life sciences: application of Mössbauer spectroscopy with a high velocity resolution in the study of iron-containing biomolecules and pharmaceutical compounds

Abstract

The 57 Fe hyperfine interactions are the useful source of information about the finest structural peculiarities in various iron-containing proteins which can be essential in the natural variety of structure and function relationship in normal biomolecules as well as in its changes in the case of molecular pathology. Mössbauer spectroscopy with a high velocity resolution as the most sensitive probe for the 57 Fe hyperfine interactions demonstrates some advances in the study of various hemoglobins, ferritins and pharmaceutical products that can bring new information for the life sciences.Keywords Mössbauer spectroscopy with a high velocity resolution Á The 57 Fe hyperfine interactions Á Ironcontaining biomolecules Á Iron-containing pharmaceutical compounds

Analyses of Ferrous and Ferric State in DynabiTabUsing Mössbauer Spectroscopy

“…Various vitamins and dietary supplements contain Fe in the form of ferrous fumarate, ferrous sulfate, and ferrous gluconate. Recently several commercial samples of Elevit (Rottendorf Pharma GmbH, Germany), Vitrum (Unifarm, Inc., USA), Children's Multi Vitamin (Target Corporation Minneapolis, USA), Multi For Her (Nature Made Nutritional Products, USA), and Multitabs (Ferrosan A/S, Denmark) containing ferrous fumarate and Sorbifer Durules (Egis, Hungary), Hemofer® (Glaxo-SmithKline Medicines S.A., Poland), Falvit® (Jelfa, Poland), and Vitaral (Jelfa, Poland) containing ferrous sulfate were studied using Mössbauer spectroscopy [ 4 – 6 ].…”

Analyses of iron electron status in Chela-Ferr biocomplex using Mössbauer Spectroscopy

“…Na rynku farmaceutycznym występuje wiele witamin i suplementów diety zawierających Fe w postaci fumaranu żelazawego, siarczanu żelazawego i glukonianu żelazawego, np. Elevit ( Rottendorf Pharma GmbH, Niemcy), Vitrum ( Unifarm, Inc., USA), Ascofer (Espefa, Polska) i ChelaFer (OlimpLabs, Polska), Hemofer ® (Glaxo-SmithKline Medicines SA, Polska), Falvit ® (Jelfa, Polska) [4,5].…”