Spleen tissues from patients with lymphoma: magnetization measurements and Mössbauer spectroscopy

Alenkina, I. V.; Виноградов, А. В.; Константинова, Т. С.; Felner, I.; Оштрах, М. И.

doi:10.1007/s10751-017-1479-6

Cited by 3 publications

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References 20 publications

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“…Next, the nanosized ferritin-like iron cores in normal human liver and spleen and liver and spleen tissues from patients with hematological malignancies were studied by Mössbauer spectroscopy with a high velocity resolution at 295 K in [ 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. Tissue samples of healthy human (NOR) spleen from donor “1” and liver from donor “2” were obtained post mortem and were used as the reference samples.…”

Section: Nanoparticles In Biology Medicine and Pharmacymentioning

confidence: 99%

Mössbauer Spectroscopy with a High Velocity Resolution in the Studies of Nanomaterials

et al. 2022

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The present review describes our long experience in the application of Mössbauer spectroscopy with a high velocity resolution (a high discretization of the velocity reference signal) in the studies of various nanosized and nanostructured iron-containing materials. The results reviewed discuss investigations of: (I) nanosized iron cores in: (i) extracted ferritin, (ii) ferritin in liver and spleen tissues in normal and pathological cases, (iii) ferritin in bacteria, (iv) pharmaceutical ferritin analogues; (II) nanoparticles developed for magnetic fluids for medical purposes; (III) nanoparticles and nanostructured FINEMET alloys developed for technical purposes. The results obtained demonstrate that the high velocity resolution Mössbauer spectroscopy permits to excavate more information and to extract more spectral components in the complex Mössbauer spectra with overlapped components, in comparison with those obtained by using conventional Mössbauer spectroscopy. This review also shows the advances of Mössbauer spectroscopy with a high velocity resolution in the study of various iron-based nanosized and nanostructured materials since 2005.

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Section: Nanoparticles In Biology Medicine and Pharmacymentioning

confidence: 99%

Mössbauer Spectroscopy with a High Velocity Resolution in the Studies of Nanomaterials

et al. 2022

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Applications of Mössbauer Spectroscopy in Biomedical Research

Оштрах

2018

Cell Biochem Biophys

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A brief review on the applications of Mössbauer spectroscopy in biomedical research discusses the results of more than fifty years of experience in this field. Basing on the numerous results the main directions of biomedical applications of Mössbauer spectroscopy are considered as follows: 1) studies of the quantitative changes of iron-containing biomolecules related to pathological processes; 2) studies of the qualitative changes in iron-containing biomolecules related to pathological processes; 3) studies of the effect of various environmental factors (physical, chemical, and biological) on iron-containing biomolecules; 4) studies of metabolic processes by means of analysis of the Mössbauer nuclides pathways in organisms; 5) studies of dynamic processes; 6) studies of pharmaceutical compounds and blood substitutes containing Mössbauer nuclides; 7) miscellaneous studies. Some examples of biomedical research using Fe,Co, Sn,Sm, and Au Mössbauer nuclides are presented.

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The Iron State in Spleen and Liver Tissues from Patients with Hematological Malignancies Studied Using Magnetization Measurements and Mössbauer Spectroscopy

Alenkina

Виноградов

Felner

et al. 2018

Cell Biochem Biophys

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In this overview, we present the results of the study of spleen and liver tissues taken from healthy donors in comparison with those from patients with (i) non-Hodgkin B-cell lymphomas, namely, mantle cell lymphoma and marginal zone B-cell lymphoma, (ii) acute myeloid leukemia, and (iii) primary myelofibrosis. The study was carried out using Mössbauer spectroscopy and magnetization measurements for the analysis of ferritin-like iron in spleen and liver tissues. Magnetization measurements demonstrated small differences in the saturation magnetic moments and revealed additional paramagnetic components. Two liver samples demonstrated unusual behavior of the magnetic moment when the zero-field-cooled curve was over the field-cooled curve in the temperature range between ~40 and ~70 K. Relative iron content variations in the tissue cells as well as small variations in the Fe hyperfine parameters were demonstrated for healthy and patients' spleen and liver tissues on the base of measured Mössbauer spectra. The results obtained permit us to suggest small differences in the ferritin iron core structure in spleen and liver tissues from healthy donors and patients with hematological malignancies.

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Spleen tissues from patients with lymphoma: magnetization measurements and Mössbauer spectroscopy

Cited by 3 publications

References 20 publications

Mössbauer Spectroscopy with a High Velocity Resolution in the Studies of Nanomaterials

Mössbauer Spectroscopy with a High Velocity Resolution in the Studies of Nanomaterials

Applications of Mössbauer Spectroscopy in Biomedical Research

The Iron State in Spleen and Liver Tissues from Patients with Hematological Malignancies Studied Using Magnetization Measurements and Mössbauer Spectroscopy

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