The 2θ determination of diffraction peaks from `poor' powder samples. Application to biological apatite

“…), the effect of microstrain depends on two theta (2θ) and therefore on the order of reflection . Note that special attention has been paid to the analysis procedure, and several works have been dedicated to the case of biomaterials …”

Section: Wide- and Small-angle X-ray And Neutron Scatteringmentioning

confidence: 99%

Characterization and Some Physicochemical Aspects of Pathological Microcalcifications

et al. 2012

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Recovery from pamidronate (APD): A two-year study in the dog

et al. 1994

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The goal of this study was to find out if bone can recover after long-term administration of bisphosphonate. Disodium pamidronate (APD) was given orally by gavage to mature beagle dogs at doses of 0, 2.5, 12.5, and 25 mg/kg/day for 1 year (0.1% concentration) and the animals were allowed to recover for another year. At sacrifice, the os ilium was used to determine bone mineralization profile and, subsequently, each density fraction was analyzed chemically. The ribs were used to determine the lattice parameters and the size of the apatite crystals of bone. The sternum was used to determine selected morphometric parameters using image analysis of specimen X-ray films and, subsequently, to determine bone mechanical properties using a 3-point bending technique. We found that the 12.5 and 25 mg/kg/day doses exhibit a significant shift towards greater mineralization versus control, whereas the lower dose (2.5 mg/kg/day) was indistinguishable from the controls. The lattice parameters and crystal size of bone apatite remained unchanged. The image analysis shows a dose-related increase in trabecular volume and thickness. The connectivity increased with dose but the anisotropy of bone remained unchanged. Both the elastic modulus and the maximum stress of bone remain unaffected by APD. We conclude that when dogs are treated with APD for 1 year, their bones can reestablish their physical-chemical characteristics (mineralization profile, chemistry, and crystal size/strain) after 1 year of recovery, provided that the treatment dose is 2.5 mg/kg/day. In addition, the mechanical properties of the bone remained unaffected and the gains in trabecular volume and thickness are maintained.

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Lesions characteristic of infection or malignant tumor in Paleo-Eskimo skulls

Lagier¹,

Baud²,

Arnaud³

et al. 1982

Virchows Arch. A Path. Anat. and Histol.

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Summary_ Study of two Paleo-Eskimo skulls found in a necropolis on St-Lawrence Island (Alaska), including radiography and histological exami nation, revealed the following features. One of the skulls showed a perfora tion with remodelled borders, considered to be due to trauma and secondary infection. The other showed areas of osteolysis characteristic of a malignant tumor (probably carcinomatous metastasis rather than myeloma).These cases illustrate the advantage of using various methods of investi gating bone pathology, particularly microradiography, in skeleton paleopath ology.

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The 2θ determination of diffraction peaks from `poor' powder samples. Application to biological apatite

Cited by 9 publications

References 6 publications

Characterization and Some Physicochemical Aspects of Pathological Microcalcifications

Characterization and Some Physicochemical Aspects of Pathological Microcalcifications

Recovery from pamidronate (APD): A two-year study in the dog

Lesions characteristic of infection or malignant tumor in Paleo-Eskimo skulls

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