The +276 Polymorphism of the <i>APM1</i> Gene, Plasma Adiponectin Concentration, and Cardiovascular Risk in Diabetic Men

Qi, Lü; Li, Tricia; Rimm, Eric B.; Zhang, Cuilin; Rifai, Nader; Hunter, David J.; Doria, Alessandro; Hu, Frank B.

doi:10.2337/diabetes.54.5.1607

Cited by 125 publications

(109 citation statements)

References 21 publications

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“…4,[25][26][27] Decreased adiponectin levels were described in weight-stable obese subjects. However, many studies have reported an association between obesity risk and hyperadiponectinemia associated with polymorphisms, 9,18,28 which were in accordance with our results. The physiological mechanisms to explain these results are a complex question to address.…”

Section: Discussionsupporting

confidence: 93%

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

et al. 2007

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Background: Adiponectin expression and plasma concentrations are decreased in human and animal models of obesity. Several single nucleotide polymorphisms (SNPs) in the adiponectin gene are known to influence the plasmatic concentration of the encoded protein. Some of these adiponectin polymorphisms have been associated with BMI in cross-sectional studies. Objective: The aim of our study was to examine the longitudinal relationships between adiponectin gene polymorphisms and anthropometric indices. Design: Two adiponectin gene (ADIPOQ) SNPs, À11391G4A and À11377C4G, were genotyped in 837 French Caucasian subjects from the SUpplémentation en VItamines et Minéraux Anti-oXydants (SU.VI.MAX) cohort. Anthropometric scores were measured at three clinical examinations over a 7-year period. Results: For À11391G4A as well as for À11377C4G, we detected no association between the variant allele and anthropometric measurements at baseline. Considering longitudinal effects, we detected moderately higher waist-to-hip ratio (WHR) changes for the carriers of the À11391A (P ¼ 0.02) and À11377C (P ¼ 0.03) allele over the follow-up of the study. À11391G4A and À11377C4G define haplotypes associated also with WHR measurements and their changes over the followup of the study. Diploid configurations that combine À11391A and À11377C were associated with significantly higher WHR changes (DCE: P ¼ 0.02) compared to other haplotypes. In addition, higher adiponectin levels were observed in AC/AC diplotypes compared to GG/GG carriers (Po0.0001). Conclusion: In the SU.VI.MAX study, genetic variations in the adiponectin gene affect abdominal fat gain over life span.

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Section: Discussionsupporting

confidence: 93%

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

et al. 2007

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“…Diabetic subjects showed that plasma adiponectin levels are significantly higher in TT homozygous T2DM patients, in accord to similar findings in the literature [36]. In addition other studies dealt with 276 G/T allele, it was found that T allele of this variant was related with higher levels of serum adiponectin and was a protective factor fordiabetes, coronary heart disease, hypertension, or dyslipidemia in American [37], Fenland [38], Japanese, and Korean [39] populations. However, the conclusions in different populations are somehow controversial.…”

Section: Discussionsupporting

confidence: 80%

Adiponectin (+276 G/T), Tumor Necrosis Factor-alpha (-308 G/A) and Interleukin-6 (-174 C/G) Genes Polymorphisms in Egyptian Type 2 Diabetic Patients

Abd-Elbaky¹,

Matty²

2016

J Diabetes Metab

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Type 2 diabetes mellitus (T2DM) is a metabolic pro-inflammatory disorder characterized by chronic hyperglycemia and increased levels of circulating cytokines. Adiponectin, tumor necrosis factor-α (TNF-α), interleukin-6 (Il-6), are important cytokines mediators in the pathogenesis of T2DM. The single nucleotide polymorphisms (SNPs) present in the regulatory regions of cytokine genes often have an impact on their expression levels.Aim: Explore potential associations between SNP+276 G/T of adiponectin, SNP -308 G/A of TNF-α and SNP -174 C/G of IL-6 genes with T2DM and to assess its influence on their serum levels. Subjects and Methods:From the Egyptian population, we enrolled 95 T2DM patients and 85 non-diabetic controls. Serum adiponectin, TNF-α and IL-6 were measured. Genotyping for three SNPs of the adiponectin, TNF-α and IL-6 genes was performed by polymerase chain reaction-restriction fragment length polymorphism.Results: Subjects with the GT/TT genotype of SNP 276 were at increased risk for T2DM (OR=15.88, CI=7.56-33.31, P ≤ 0.01) and associated with hypoadiponectinemia compared with the GG genotype. Furthermore, the allelic frequency of the A allele of SNP 308 was significantly different between T2DM patients compared to controls (X 2 =30.54, P ≤ 0.0001). Moreover, Individuals with T2DM carrying the GA/AA genotypes had significantly higher serum TNF-α levels than those carrying GG genotype. In addition, Carriers of G allele of IL-6 were significantly more likely associated with T2DM.

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“…However, SNP45T4G alone did not have any significant association. Furthermore, Qi et al 24 recently found significant associations between ADIPOQ SNP276G4T and increased plasma adiponectin levels and decreased cardiovascular risk in diabetic men. Taken together, a haplotype including SNPs À11391 and À11377 in the proximal region was found to be associated with the risk of type 2 diabetes in French Caucasian.…”

Section: Discussionmentioning

confidence: 97%

The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

et al. 2006

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Objective: The purpose of this study was to determine whether common single nucleotide polymorphisms (SNPs) at the adiponectin (ADIPOQ) locus influence changes in circulating adiponectin and the features of insulin resistance in response to a weight loss intervention. Subjects: In total, 294 nondiabetic/overweight-obese Koreans participated in a clinical intervention study lasting 12 weeks involving a caloric reduction of À300kcal/day. Methods: Plasma adiponectin, blood lipids, glucose and insulin concentrations were measured at baseline and after weight loss. Insulin resistance was estimated by homeostasis model assessment insulin resistance (HOMA-IR) derived from fasting glucose and insulin concentrations. We genotyped for three SNPs, 45T4G, 276G4T and À11377C4G. Results: At baseline, HOMA-IR was significantly higher in GG homozygotes than in carriers of the T allele at SNP276G4T of the adiponectin gene (Po0.05). With regard to SNP45T4G and SNP À11377C4G, we did not find any genotype related differences in baseline levels of HOMA-IR and adiponectin. In the 45/276 haplotype test, homozygous for the TG haplotype had significantly lower concentrations of plasma adiponectin (Po0.05). After the 12-week weight loss intervention, the significant decreases in HOMA-IR (Po0.001) and increases in adiponectin (Po0.01) were observed in GG homozygotes at SNP276, which were not shown in carriers of the T allele. Furthermore, there was a significant difference in the decreases in HOMA-IR between the GG homozygotes and carriers of the T allele at SNP276 (Po0.05). Regarding SNP45T4G and SNP À11377C4G, there was no association between SNP45T4G and SNP À11377C4G and decreases in HOMA-IR. In the 45/276 haplotype test, there was a significant difference in changes of adiponectin levels among those with different haplotype combinations (Po0.05). Conclusion: The SNP276G4T of the ADIPOQ gene is associated with different responses of circulating adiponectin and insulin resistance to mild weight loss in overweight-obese subjects.

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The +276 Polymorphism of the APM1 Gene, Plasma Adiponectin Concentration, and Cardiovascular Risk in Diabetic Men

Cited by 125 publications

References 21 publications

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

Adiponectin (+276 G/T), Tumor Necrosis Factor-alpha (-308 G/A) and Interleukin-6 (-174 C/G) Genes Polymorphisms in Egyptian Type 2 Diabetic Patients

The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

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