The 2 stromal compartments of the normal cervix with distinct immunophenotypic and histomorphologic features

Kling, Elaine; Kitahara, Sumire; Posligua, Lorena; Malpica, Anaís; Silva, Elvio G.

doi:10.1016/j.anndiagpath.2011.12.002

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…15,80–83 The lack of association between strain in the sagittal plane and spontaneous preterm delivery can be related to the mixture of strain values from different areas of the cervix. Applying other methods, such as ultrasound attenuation, 84–86 gray-level histogram characteristics, 87,88 or shear wave elastography, 78,79,89 or using reference materials for strain comparisons, 90 may allow for the reliable evaluation of cervical regions other than the internal os.…”

Section: Discussionmentioning

confidence: 99%

Strain at the internal cervical os assessed with quasi-static elastography is associated with the risk of spontaneous preterm delivery at ≤34 weeks of gestation

Hernández‐Andrade

Garcia

Ahn

et al. 2015

Journal of Perinatal Medicine

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Aim To evaluate the association between cervical strain assessed with quasi-static elastography and spontaneous preterm delivery. Methods Quasi-static elastography was used to estimate cervical strain in 545 pregnant women with singleton pregnancies from 11 weeks to 28 weeks of gestation. Cervical strain was evaluated in one sagittal plane and in the cross-sectional planes of the internal cervical os and external cervical os. The distribution of strain values was categorized into quartiles for each studied region and their association with spontaneous preterm delivery at ≤34 weeks and at <37 weeks of gestation was evaluated using logistic regression. Results The prevalence of spontaneous preterm delivery at <37 weeks of gestation was 8.2% (n=45), and that at ≤34 weeks of gestation was 3.8% (n=21). Strain in the internal cervical os was the only elastography value associated with spontaneous preterm delivery. Women with strain values in the third and fourth quartiles had a significantly higher risk of spontaneous preterm delivery at ≤34 weeks and at <37 weeks of gestation when compared to women with strain values in the lowest quartile. When adjusting for a short cervix (<25 mm) and gestational age at examination, women with strain values in the third quartile maintained a significant association with spontaneous preterm delivery at ≤34 weeks (OR 9.0; 95% CI, 1.1–74.0; p=0.02), whereas women with strain values in the highest quartile were marginally more likely than women with lowest quartile strain values to deliver spontaneously at ˂37 weeks of gestation (OR 2.8; 95% CI: 0.9–9.0; p=0.08). Conclusion Increased strain in the internal cervical os is associated with higher risk of spontaneous preterm delivery both at ≤34 and <37 weeks of gestation.

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Section: Discussionmentioning

confidence: 99%

Strain at the internal cervical os assessed with quasi-static elastography is associated with the risk of spontaneous preterm delivery at ≤34 weeks of gestation

Hernández‐Andrade

Garcia

Ahn

et al. 2015

Journal of Perinatal Medicine

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“…This difference in shear-wave propagation might be related to differences in tissue constitution as values remained significant after adjustment by depth. The velocity of propagation of the shear-wave can be related to the alignment and organization of the collagen network, concentration of proteoglycans [39] [40-44], and the amount of smooth muscle cells [45, 46] [47] in different cervical regions.…”

Section: Discussionmentioning

confidence: 99%

Effect of depth on shear-wave elastography estimated in the internal and external cervical os during pregnancy

Hernández‐Andrade

Aurioles-Garibay

Garcia

et al. 2014

Journal of Perinatal Medicine

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Aim To investigate the effect of depth on cervical shear-wave elastography. Methods Shear-wave elastography was applied to estimate the velocity of propagation of the acoustic force impulse (shear-wave) in the cervix of 154 pregnant women at 11-36 weeks of gestation. Shear-wave speed (SWS) was evaluated in cross-sectional views of the internal and external cervical os in five regions of interest: anterior, posterior, lateral right, lateral left, and endocervix. Distance from the center of the US transducer to the center of the each region of interest was registered. Results In all regions, SWS decreased significantly with gestational age (p=0.006). In the internal os SWS was similar among the anterior, posterior and lateral regions, and lower in the endocervix. In the external os, the endocervix and anterior regions showed similar SWS values, lower than those from the posterior and lateral regions. In the endocervix, these differences remained significant after adjustment for depth, gestational age and cervical length. SWS estimations in all regions of the internal os were higher than those of the external os, suggesting denser tissue. Conclusion Depth from the ultrasound probe to different regions in the cervix did not significantly affect the SWS estimations.

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Section: Anatomy and Function Of The Adult Human Female Reproductive Tractmentioning

confidence: 99%

“…Two distinct types of sub-epithelial stromal cell compartments underlie the ectocervical squamous and endocervical columnar epithelium [ 78 , 84 ]. The ectocervical stroma is desmin+/smooth muscle actin (SMA)− whilst the endocervical stroma is desmin−/SMA+/CD34+ [ 84 ]. The regenerative potential of squamous and columnar epithelia is controlled by distinct Wnt signals from the stromal compartment.…”

Section: Anatomy and Function Of The Adult Human Female Reproductive Tractmentioning

confidence: 99%

Organoids of the female reproductive tract

Chumduri

Turco

2021

J Mol Med

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Healthy functioning of the female reproductive tract (FRT) depends on balanced and dynamic regulation by hormones during the menstrual cycle, pregnancy and childbirth. The mucosal epithelial lining of different regions of the FRT—ovaries, fallopian tubes, uterus, cervix and vagina—facilitates the selective transport of gametes and successful transfer of the zygote to the uterus where it implants and pregnancy takes place. It also prevents pathogen entry. Recent developments in three-dimensional (3D) organoid systems from the FRT now provide crucial experimental models that recapitulate the cellular heterogeneity and physiological, anatomical and functional properties of the organ in vitro. In this review, we summarise the state of the art on organoids generated from different regions of the FRT. We discuss the potential applications of these powerful in vitro models to study normal physiology, fertility, infections, diseases, drug discovery and personalised medicine.

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The 2 stromal compartments of the normal cervix with distinct immunophenotypic and histomorphologic features

Cited by 5 publications

References 37 publications

Strain at the internal cervical os assessed with quasi-static elastography is associated with the risk of spontaneous preterm delivery at ≤34 weeks of gestation

Strain at the internal cervical os assessed with quasi-static elastography is associated with the risk of spontaneous preterm delivery at ≤34 weeks of gestation

Effect of depth on shear-wave elastography estimated in the internal and external cervical os during pregnancy

Organoids of the female reproductive tract

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