The 195Pt chemical shifts and 195Pt15N coupling constants for cis-diammineplatinum(II) complexes

The hydrolysis reactions of complexes of the type Pt(L)X, where L is ethylenediamine (en), N, Ndimethylethylenediamine (N,N-Me,en), N,N-dimethylethylenediamine (N,N'-MeZen) and N,N,N',N'tetramethylethylenediamine (Me,en) were studied. The halo ligands were removed by precipitation with AgNO, and the pH of the resulting filtrate, which was about 2, was adjusted to 5.8 (pD = 6.2). The study of the products formed was carried out by multinuclear NMR spectroscopy. The 195Pt NMR spectra showed the presence of several hydrolysed products, especially with en. The hydroxo-bridged dimer can be synthesized in a pure state with all the ligands except en. The results on the latter ligand contradict the published results on the synthesis of the en hydroxo-bridged dimer whose biological properties were studied. When Pt(L)I, is used as starting material a small quantity of chloro species was always observed, indicating that the reactant contained a small quantity of Pt(L)ICI. The crystal structure of the [ Pt(N,N-Me,en)(p-OH)] ,(NO,), dimer was determined. The compound belongs to the R 1 / c space group, with a = 8.262(5), b = 10.960(8), c = 11.405(8), fl = 121.07(5)", Z = 2 and penle = 2.720 mg m-3. The results showed that this is the trans isomer with an inversion centre between the two Pt atoms. There is a considerable strain inside the four-membered ring, as shown by the reduced internal angles 0-Pt-0' = 79.1(6)" and Pt--O-Pt' = 101.q6)".

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¹⁹⁵Pt and ¹H NMR study of the products of hydrolysis of Pt(L)X₂, where L is an ethylenediamine derivative, and the crystal structure of [Pt(N,N‐dimethylethylenediamine) (μ‐OH)]₂ (NO₃)₂

Rochon

Melanson

Morneau

1992

Magnetic Reson in Chemistry

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Multinuclear magnetic resonance studies of the hydrolyzed and aquated species of the antitumor complexes cis-Pt(cyclobutylamine)2X2 and cis-Pt(NH3)(cyclobutylamine)X2 and antitumor testing of mixed-amine Pt(II) compounds

Dion

Beauchamp

Rochon

2009

Inorganica Chimica Acta

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Platinum(II) Complexes with Diglycine: X-ray Crystal Structure, ¹⁵N NMR Spectra, and Growth-Inhibitory Activity against Mouse Meth A Solid Tumor in Vivo

et al. 1997

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Two new dipeptide complexes of the form H[Pt(digly)Cl] (2) (H2digly = glycylglycine) and H[Pt(Hdigly)Cl2] (4) were newly prepared, and K[Pt(Hdigly)Cl2] (3) was isolated. Complex 1, K[Pt(digly)Cl], crystallizes in the monoclinic space group C2/c with unit cell dimensions a = 25.77(1) Å, b = 4.09(2) Å, c = 16.432(9) Å, β = 103.74(4)°, and Z = 8. Complex 3 crystallizes in the monoclinic space group P21/c with unit cell dimensions a = 8.892(5) Å, b = 11.387(4) Å, c = 9.974(4) Å, β = 105.45(4)°, Z = 4. Complex 4 crystallizes in the monoclinic space group P21/c with unit cell dimensions a = 9.311(6) Å, b = 7.737(8), c = 15.627(4) Å, β = 105.92(3)°, Z = 4. Complex 4 has the rare iminol type H2digly coordinating to Pt. The 15N chemical shifts and the coupling constants of the deprotonated coordinated amide N were obtained for the first time for these complexes. These amide peaks showed almost no coordination shift compared with the large coordination shift of the amine nitrogen. The coupling constants between Pt and deprotonated nitrogen for K[Pt(Hdipep)Cl2] were larger than those for K[Pt(dipep)Cl]. The growth inhibition assays of K[Pt(digly)Cl], K[Pt(Hdigly)Cl2], and cis-diamminedichloroplatinum(II) (cisplatin) against methylcholanthrene-induced Meth A fibrosarcoma (Meth A) solid tumor transplanted in BALB/c mice were measured. In mice, 35.9% of slight growth inhibition was observed in the group administered with K[Pt(digly)Cl] (dose of 26 mg/kg/day), and 40.6% in the group administered with K[Pt(Hdigly)Cl2] (dose of 52 mg/kg/day), and 45.3% cisplatin (dose of 10 mg/kg/day). The side effects related to the decrease in body weight are milder than that of cisplatin. Their toxicity against normal mouse bone marrow cells was measured. All of them exhibited toxicity against bone marrow cells, but K[Pt(digly)Cl] and K[Pt(Hdigly)Cl2] had only 1/10 the toxicity of cisplatin.

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The 195Pt chemical shifts and 195Pt15N coupling constants for cis-diammineplatinum(II) complexes

Cited by 3 publications

References 11 publications

¹⁹⁵Pt and ¹H NMR study of the products of hydrolysis of Pt(L)X₂, where L is an ethylenediamine derivative, and the crystal structure of [Pt(N,N‐dimethylethylenediamine) (μ‐OH)]₂ (NO₃)₂

¹⁹⁵Pt and ¹H NMR study of the products of hydrolysis of Pt(L)X₂, where L is an ethylenediamine derivative, and the crystal structure of [Pt(N,N‐dimethylethylenediamine) (μ‐OH)]₂ (NO₃)₂

Multinuclear magnetic resonance studies of the hydrolyzed and aquated species of the antitumor complexes cis-Pt(cyclobutylamine)2X2 and cis-Pt(NH3)(cyclobutylamine)X2 and antitumor testing of mixed-amine Pt(II) compounds

Platinum(II) Complexes with Diglycine: X-ray Crystal Structure, ¹⁵N NMR Spectra, and Growth-Inhibitory Activity against Mouse Meth A Solid Tumor in Vivo

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The 195Pt chemical shifts and 195Pt15N coupling constants for cis-diammineplatinum(II) complexes

Cited by 3 publications

References 11 publications

195Pt and 1H NMR study of the products of hydrolysis of Pt(L)X2, where L is an ethylenediamine derivative, and the crystal structure of [Pt(N,N‐dimethylethylenediamine) (μ‐OH)]2 (NO3)2

195Pt and 1H NMR study of the products of hydrolysis of Pt(L)X2, where L is an ethylenediamine derivative, and the crystal structure of [Pt(N,N‐dimethylethylenediamine) (μ‐OH)]2 (NO3)2

Multinuclear magnetic resonance studies of the hydrolyzed and aquated species of the antitumor complexes cis-Pt(cyclobutylamine)2X2 and cis-Pt(NH3)(cyclobutylamine)X2 and antitumor testing of mixed-amine Pt(II) compounds

Platinum(II) Complexes with Diglycine: X-ray Crystal Structure, 15N NMR Spectra, and Growth-Inhibitory Activity against Mouse Meth A Solid Tumor in Vivo

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¹⁹⁵Pt and ¹H NMR study of the products of hydrolysis of Pt(L)X₂, where L is an ethylenediamine derivative, and the crystal structure of [Pt(N,N‐dimethylethylenediamine) (μ‐OH)]₂ (NO₃)₂

¹⁹⁵Pt and ¹H NMR study of the products of hydrolysis of Pt(L)X₂, where L is an ethylenediamine derivative, and the crystal structure of [Pt(N,N‐dimethylethylenediamine) (μ‐OH)]₂ (NO₃)₂

Platinum(II) Complexes with Diglycine: X-ray Crystal Structure, ¹⁵N NMR Spectra, and Growth-Inhibitory Activity against Mouse Meth A Solid Tumor in Vivo