The recently published ‘Stele from the Harbour’ of Thasos provides important new evidence for the topography of the ancient city. Some streets and other topographical features are named or described. There are many problems, however, in locating these features on the ground. These problems are fully discussed and some new solutions are proposed. At the same time, the new evidence bears on several difficult and unresolved topographical questions, which have long engaged the attention of students of Thasos. These questions are, therefore, reconsidered here. Finally, the important evidence for the topography of the city, which is found in the Hippocratean Epidemics, is fully set out for the first time, and discussed in relation to the archaeological evidence.