Thallium distribution in organs and brain regions of developing rats

Short-term toxicity studies of thallium (I) sulfate administered in drinking water to Sprague Dawley rats and B6C3F1/N mice

“…Increases in relative kidney weight were also noted; however, this finding was likely a result of changes in body weight and not directly related to exposure. While findings in the kidney were not considered exposure-related in the studies reported here, thallium has been shown to readily accumulate in the kidney following intraperitoneal injection [47] , [48] , and increases in kidney weight were previously noted in studies of Wistar albino rats exposed to thallium (I) acetate or thallium (III) oxide in the diet for 15 weeks [49] . Leloux et al (1987) [50] also reported increases in absolute kidney weight in male and female rats following a single gavage dose (20 mg/kg) or four daily gavage doses (1 mg/kg/day) thallium (I) nitrate.…”

Short-term toxicity studies of thallium (I) sulfate administered in drinking water to Sprague Dawley rats and B6C3F1/N mice

“…Increases in relative kidney weight were also noted; however, this finding was likely a result of changes in body weight and not directly related to exposure. While findings in the kidney were not considered exposure-related in the studies reported here, thallium has been shown to readily accumulate in the kidney following intraperitoneal injection [47] , [48] , and increases in kidney weight were previously noted in studies of Wistar albino rats exposed to thallium (I) acetate or thallium (III) oxide in the diet for 15 weeks [49] . Leloux et al (1987) [50] also reported increases in absolute kidney weight in male and female rats following a single gavage dose (20 mg/kg) or four daily gavage doses (1 mg/kg/day) thallium (I) nitrate.…”

Toxicity of thallium on isolated rat liver mitochondria: The role of oxidative stress and MPT pore opening

“…This ability of thallium(I) can alter membrane fluidity, which ultimately leads to disruption of membrane‐associated metabolic processes (Heim et al, ). Besides, studies in various animal tissues using different administration schemes suggested that thallium toxicity is closely associated with ROS formation, which further causes tissue damage and organ dysfunction (Galván‐Arzate and Ríos, ; Galván‐Arzate et al, ; Pourahmad et al, ; Eskandari et al, ).…”

Metales interesantes de la familia III A: contaminación, toxicocinética y genotoxicidad del galio, indio y talio

“…La mayoría de las sales de Tl se absorben rápidamente y pueden ser detectables en plasma sanguíneo y en los tejidos y órganos 1 h después de la exposición. Una vez en el organismo, el Tl se distribuye mediante la circulación sistémica, acumulándose en cerebro, corazón, hígado, riñones, gónadas, músculo y hueso (Galván-Arzate y Ríos 1994, USEPA 2009, Rodríguez-Mercado y Altamirano-Lozano 2013).…”

“…En organismos recién nacidos el Tl se distribuye uniformemente en el cerebro, mientras que en los adultos se concentra en regiones específicas. Un comportamiento similar se observó en los testículos, ya que ratas macho adultas acumularon menos Tl que los machos jóvenes, lo cual se puede adjudicar al desarrollo de la barrera hematotesticular (Ríos et al 1989, Galván-Arzate y Ríos 1994. La acumulación del Tl en el corazón es atribuible al intercambio del Tl 1+ por el K 1+ en el músculo cardíaco (Achenbach et al 1980).…”

Short-term toxicity studies of thallium (I) sulfate administered in drinking water to Sprague Dawley rats and B6C3F1/N mice

“…Increases in relative kidney weight were also noted; however, this finding was likely a result of changes in body weight and not directly related to exposure. While findings in the kidney were not considered exposure-related in the studies reported here, thallium has been shown to readily accumulate in the kidney following intraperitoneal injection [47] , [48] , and increases in kidney weight were previously noted in studies of Wistar albino rats exposed to thallium (I) acetate or thallium (III) oxide in the diet for 15 weeks [49] . Leloux et al (1987) [50] also reported increases in absolute kidney weight in male and female rats following a single gavage dose (20 mg/kg) or four daily gavage doses (1 mg/kg/day) thallium (I) nitrate.…”

Toxicity of thallium on isolated rat liver mitochondria: The role of oxidative stress and MPT pore opening

“…This ability of thallium(I) can alter membrane fluidity, which ultimately leads to disruption of membrane‐associated metabolic processes (Heim et al, ). Besides, studies in various animal tissues using different administration schemes suggested that thallium toxicity is closely associated with ROS formation, which further causes tissue damage and organ dysfunction (Galván‐Arzate and Ríos, ; Galván‐Arzate et al, ; Pourahmad et al, ; Eskandari et al, ).…”

Metales interesantes de la familia III A: contaminación, toxicocinética y genotoxicidad del galio, indio y talio

“…La mayoría de las sales de Tl se absorben rápidamente y pueden ser detectables en plasma sanguíneo y en los tejidos y órganos 1 h después de la exposición. Una vez en el organismo, el Tl se distribuye mediante la circulación sistémica, acumulándose en cerebro, corazón, hígado, riñones, gónadas, músculo y hueso (Galván-Arzate y Ríos 1994, USEPA 2009, Rodríguez-Mercado y Altamirano-Lozano 2013).…”

“…En organismos recién nacidos el Tl se distribuye uniformemente en el cerebro, mientras que en los adultos se concentra en regiones específicas. Un comportamiento similar se observó en los testículos, ya que ratas macho adultas acumularon menos Tl que los machos jóvenes, lo cual se puede adjudicar al desarrollo de la barrera hematotesticular (Ríos et al 1989, Galván-Arzate y Ríos 1994. La acumulación del Tl en el corazón es atribuible al intercambio del Tl 1+ por el K 1+ en el músculo cardíaco (Achenbach et al 1980).…”

Short-term toxicity studies of thallium (I) sulfate administered in drinking water to Sprague Dawley rats and B6C3F1/N mice

“…Increases in relative kidney weight were also noted; however, this finding was likely a result of changes in body weight and not directly related to exposure. While findings in the kidney were not considered exposure-related in the studies reported here, thallium has been shown to readily accumulate in the kidney following intraperitoneal injection [47] , [48] , and increases in kidney weight were previously noted in studies of Wistar albino rats exposed to thallium (I) acetate or thallium (III) oxide in the diet for 15 weeks [49] . Leloux et al (1987) [50] also reported increases in absolute kidney weight in male and female rats following a single gavage dose (20 mg/kg) or four daily gavage doses (1 mg/kg/day) thallium (I) nitrate.…”

Toxicity of thallium on isolated rat liver mitochondria: The role of oxidative stress and MPT pore opening

“…This ability of thallium(I) can alter membrane fluidity, which ultimately leads to disruption of membrane‐associated metabolic processes (Heim et al, ). Besides, studies in various animal tissues using different administration schemes suggested that thallium toxicity is closely associated with ROS formation, which further causes tissue damage and organ dysfunction (Galván‐Arzate and Ríos, ; Galván‐Arzate et al, ; Pourahmad et al, ; Eskandari et al, ).…”

Metales interesantes de la familia III A: contaminación, toxicocinética y genotoxicidad del galio, indio y talio

“…La mayoría de las sales de Tl se absorben rápidamente y pueden ser detectables en plasma sanguíneo y en los tejidos y órganos 1 h después de la exposición. Una vez en el organismo, el Tl se distribuye mediante la circulación sistémica, acumulándose en cerebro, corazón, hígado, riñones, gónadas, músculo y hueso (Galván-Arzate y Ríos 1994, USEPA 2009, Rodríguez-Mercado y Altamirano-Lozano 2013).…”

“…En organismos recién nacidos el Tl se distribuye uniformemente en el cerebro, mientras que en los adultos se concentra en regiones específicas. Un comportamiento similar se observó en los testículos, ya que ratas macho adultas acumularon menos Tl que los machos jóvenes, lo cual se puede adjudicar al desarrollo de la barrera hematotesticular (Ríos et al 1989, Galván-Arzate y Ríos 1994. La acumulación del Tl en el corazón es atribuible al intercambio del Tl 1+ por el K 1+ en el músculo cardíaco (Achenbach et al 1980).…”