Thalidomide reduces mechanical hyperalgesia and depressive-like behavior induced by peripheral nerve crush in mice

Nascimento, Francisney Pinto do; Macedo-Júnior, Sérgio José; Borges, Fábio Rodrigo Mesquita; Cremonese, Rafael; Silva, Morgana Duarte da; Luiz-Cerutti, Murilo; Martins, Daniel Fernandes; Rodrigues, Ana Lúcia S.; Santos, Adair R.S.

doi:10.1016/j.neuroscience.2015.06.044

Cited by 23 publications

(13 citation statements)

References 46 publications

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“…Furthermore, the expected effects of FLX in Porsolt test were absent even after the intraperitoneal injection or the housing of the male Swiss mice in standard or inverted light/dark cycle. Present data were surprising because previous studies have shown that oral treatment with antidepressants reduced the immobility time of Swiss mice in the Porsolt test in a variety of experimental conditions (19,20,27–31). A paper reporting conditions similar to those here (Swiss mice, oral treatment, behavioural testing in the afternoon, blinding, and randomisation) found an effect size above 60% for FLX treatment on immobility time (29).…”

Section: Discussioncontrasting

confidence: 73%

Failure to detect the action of antidepressants in the forced swim test in Swiss mice

Suman

Zerbinatti

Theindl

et al. 2017

Acta Neuropsychiatr.

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Section: Discussioncontrasting

confidence: 73%

Failure to detect the action of antidepressants in the forced swim test in Swiss mice

Suman

Zerbinatti

Theindl

et al. 2017

Acta Neuropsychiatr.

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“…It is well recognized that neuroimmune alterations play vital roles in the course of pain and depression 9, 11, 55 . Nerve injury results in mood disturbance associated with up-regulation of IL-1β 24 , IL-6 26 and TNF-α 56 in the PFC, and inhibition of inflammation rescues mood disturbance. Inflammatory signaling is triggered after peripheral nerve injury, which projects to the several supraspinal regions (including the PFC) via neural, humoral or cellular pathways 57 .…”

Section: Discussionmentioning

confidence: 99%

Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: improvement by ketamine

Xie

Wang

et al. 2017

Sci Rep

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Although pain is frequently accompanied with depression, little is known about the risk factors contributing to individual differences to the comorbidity of pain and depression. In this study, we examined whether cytokines and brain-derived neurotrophic factor (BDNF) might contribute to the individual differences in the development of neuropathic pain-induced depression. Rats were randomly subjected to spared nerved ligation (SNI) or sham surgery. The SNI rats were divided into two groups by the data from depression-related behavioral tests. Rats with depression-like phenotype displayed higher levels of pro-inflammatory cytokines (e.g., interleukin (IL)-1β, IL-6) as well as imbalance of pro/anti-inflammatory cytokines compared with rats without depression-like phenotype and sham-operated rats. Levels of BDNF in the prefrontal cortex of rats with depression-like phenotype were lower than those of rats without depression-like phenotype and sham-operated rats. A single dose of ketamine ameliorated depression-like behaviors in the rats with depression-like phenotype. Interestingly, higher serum levels of IL-1β and IL-6 in the rat with depression-like phenotype were normalized after a single dose of ketamine. These findings suggest that alterations in the inflammatory cytokines and BDNF might contribute to neuropathic pain-induced depression, and that serum cytokines may be predictable biomarkers for ketamine’s antidepressant actions.

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“…Thalidomide is another promising approach for NP treatment. Some animal studies have demonstrated that oral or intraperitoneal injection of thalidomide can not only reduce NP responses but also mediate depressive-like behaviors associated with NP [ 49 , 50 ]. The others, including natalizumab, rituximab, daclizumab, and ibrutinib, have not been reported as NP therapeutic drugs.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic Analysis of Neuroimmune Mechanism of Neuropathic Pain

Hao

Liu

et al. 2020

BioMed Research International

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Background. Neuropathic pain (NP) is a devastating complication following nerve injury, and it can be alleviated by regulating neuroimmune direction. We aimed to explore the neuroimmune mechanism and identify some new diagnostic or therapeutic targets for NP treatment via bioinformatic analysis. Methods. The microarray GSE18803 was downloaded and analyzed using R. The Venn diagram was drawn to find neuroimmune-related differentially expressed genes (DEGs) in neuropathic pain. Gene Ontology (GO), pathway enrichment, and protein-protein interaction (PPI) network were used to analyze DEGs, respectively. Besides, the identified hub genes were submitted to the DGIdb database to find relevant therapeutic drugs. Results. A total of 91 neuroimmune-related DEGs were identified. The results of GO and pathway enrichment analyses were closely related to immune and inflammatory responses. PPI analysis showed two important modules and 8 hub genes: PTPRC, CD68, CTSS, RAC2, LAPTM5, FCGR3A, CD53, and HCK. The drug-hub gene interaction network was constructed by Cytoscape, and it included 24 candidate drugs and 3 hub genes. Conclusion. The present study helps us better understand the neuroimmune mechanism of neuropathic pain and provides some novel insights on NP treatment, such as modulation of microglia polarization and targeting bone resorption. Besides, CD68, CTSS, LAPTM5, FCGR3A, and CD53 may be used as early diagnostic biomarkers and the gene HCK can be a therapeutic target.

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Thalidomide reduces mechanical hyperalgesia and depressive-like behavior induced by peripheral nerve crush in mice

Cited by 23 publications

References 46 publications

Failure to detect the action of antidepressants in the forced swim test in Swiss mice

Failure to detect the action of antidepressants in the forced swim test in Swiss mice

Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: improvement by ketamine

Bioinformatic Analysis of Neuroimmune Mechanism of Neuropathic Pain

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