Failure to detect the action of antidepressants in the forced swim test in Swiss mice

Suman, Patrick Remus; Zerbinatti, Nathalia; Theindl, Laís Cristina; Domingues, Karolina; Oliveira, Cilene Lino de

doi:10.1017/neu.2017.33

Cited by 12 publications

(7 citation statements)

References 38 publications

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“…Changes to behavior and physiological responses to stressors may not be observable in subjects considered normal with respect to anxiety traits. In a recent study examining the effects of chronic oral treatment of SW mice with the antidepressants buproprion, desipramine, and fluoxetine, all failed to result in antidepressant-like behavior as measured in the FST (Suman et al, 2017 ). Indeed in another study measuring responses to chronic fluoxetine in a variety of mouse strains, a paradoxical increase in immobility in the TST was observed in the SW mice (Miller et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Mouse Strain Affects Behavioral and Neuroendocrine Stress Responses Following Administration of Probiotic Lactobacillus rhamnosus JB-1 or Traditional Antidepressant Fluoxetine

2018

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Currently, there is keen interest in the development of alternative therapies in the treatment of depression. Given the explosion of research focused on the microbiota-gut-brain axis, consideration has turned to the potential of certain probiotics to improve patient outcomes for those suffering from mood disorders. Here we examine the abilities of a known antidepressant, fluoxetine, and the probiotic Lactobacillus rhamnosus JB-1™, to attenuate responses to two established criteria for depressive-like behavior in animal models, the tail suspension test (TST) and the corticosterone response to an acute restraint stressor. We examine two different strains of mice known to differ in the extent to which they express both anxiety-like behavior and measures of despair—BALB/c and Swiss Webster—with respectively high and normal behavioral phenotypes for each. While adult male BALB/c mice responded with increased antidepressive-like behavior to both fluoxetine and L. rhamnosus JB-1 in both the TST and the corticosterone stress response, SW mice did not respond to either treatment as compared to controls. These findings highlight the importance of investigating putative antidepressants in mouse strains known to express face validity for some markers of depression. Clinical studies examining the activity of L. rhamnosus JB-1 in patients suffering from mood disorders are warranted, as well as further pre-clinical work examining how interactions between host genotype and intestinal microbial alterations may impact behavioral responses. This study adds to the literature supporting the possibility that modifying the intestinal microbiota via probiotics represents a promising potential therapeutic breakthrough in the treatment of psychiatric disease.

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Section: Discussionmentioning

confidence: 99%

Mouse Strain Affects Behavioral and Neuroendocrine Stress Responses Following Administration of Probiotic Lactobacillus rhamnosus JB-1 or Traditional Antidepressant Fluoxetine

2018

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“…There were no significant differences between the groups in the results of the forced swim test performed on the second day, when it was considered that the mouse already had a good understanding of the test environment. It has been shown that immobility time increases 7 and 14 days after the initial test 33 . Further research is needed to investigate this phenomenon and its association with memory processes.…”

Section: Discussionmentioning

confidence: 99%

Effect of simultaneous testing of two mice in the tail suspension test and forced swim test

Ueno

Takahashi

Murakami

et al. 2022

Sci Rep

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In mouse studies, the results of behavioural experiments are greatly affected by differences in the experimental environment and handling methods. The Porsolt forced swim test and tail suspension test are widely used to evaluate predictive models of depression-like behaviour in mice. It has not been clarified how the results of these tests are affected by testing single or multiple mice simultaneously. Therefore, this study evaluated the differences between testing two mice simultaneously or separately. To investigate the effect of testing multiple mice simultaneously, the Porsolt forced swim test and tail suspension test were performed in three patterns: (1) testing with an opaque partition between two mice, (2) testing without a partition between two mice, and (3) testing a single mouse. In the Porsolt forced swim test, the mice tested simultaneously without a partition demonstrated increased immobility time as compared to mice tested alone. No difference in immobility time was observed between the three groups in the tail suspension test. Our results showed that the environment of behavioural experiments investigating depression-like behaviour in mice can cause a difference in depression-like behaviour. The results of this experiment indicated that it is necessary to describe the method used for behavioural testing in detail.

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“…The level of carbolines was measured in the blood before and after death and in the organs [43,44,45,46]. The effects of β-carbolines on the living animal were most commonly tested behaviorally using the forced swim test, various types of the maze, and light/dark boxes [29,47,48,49].…”

Section: β-Carbolines In Experiments On Laboratory Animalsmentioning

confidence: 99%

Bioactive β-Carbolines in Food: A Review

2019

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Harman and norharman, two neuroactive β-carbolines, are present in several plants and in thermally processed foods. They exhibited a wide spectrum of biological and pharmacological effects, including antioxidant, neuroprotective, and anti-inflammatory effects. In this article, we review the progress of recent research on the presence of these compounds in food, as well as their various biological and neuroactive properties. Our findings strongly suggest that some foods, especially coffee, can act as a rich source of β-carbolines, which may possibly be associated with a reduced risk for serious neurodegenerative diseases, such as Parkinson’s and Alzheimer’s.

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Failure to detect the action of antidepressants in the forced swim test in Swiss mice

Abstract: Data suggest the lack of efficacy of orally administered bupropion, desipramine, fluoxetine in the FST in Swiss mice. High variability, due to high and low immobility mice, may explain the limited effects of the treatments.

Cited by 12 publications

References 38 publications

Mouse Strain Affects Behavioral and Neuroendocrine Stress Responses Following Administration of Probiotic Lactobacillus rhamnosus JB-1 or Traditional Antidepressant Fluoxetine

Mouse Strain Affects Behavioral and Neuroendocrine Stress Responses Following Administration of Probiotic Lactobacillus rhamnosus JB-1 or Traditional Antidepressant Fluoxetine

Effect of simultaneous testing of two mice in the tail suspension test and forced swim test

Bioactive β-Carbolines in Food: A Review

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