Thalidomide but not pentoxifylline lowers portal pressure in human alcoholic cirrhosis

Austin, A.S.; Mahida, YR; Ryder, SD; Freeman, Jan G.

doi:10.1016/s0168-8278(01)80931-4

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“…Austin et al (2001) proved that blockade of TNF-␣ activity by PTX reduces PP in portal-vein-ligated rats. Also, Ahmed et al (2012) showed that oral administration of PTX (100 mg·kg -1 ) ameliorated hyperdynamic circulation syndrome and reduced PP through intracellular accumulation of cAMP and NO levels in a rat model of portal vein ligation.…”

Section: Fig 4 (A-i) Photomicrographs Of Liver Sections From (A) Comentioning

confidence: 97%

Hepatoprotective effects of early pentoxifylline administration on hepatic injury induced by concanavalin A in rat

Mohamed

Elmelegy

El-Aziz

et al. 2014

Can. J. Physiol. Pharmacol.

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Tumor necrosis factor alpha (TNF-α) plays an important role in the pathogensis of hepatitis C virus (HCV) infection induced liver injury. This study aimed to evaluate the effects of TNF-α inhibition with pentoxifylline (PTX) on concanavalin A (Con A)-induced hepatic injury in rats. The rats were distributed among 3 groups: (i) control group (1 mL saline·week(-1) by intravenous injection (i.v.)); (ii) Con A treatment group (20 mg Con A·(kg body mass)(-1)·week(-1), i.v.), and (iii) rats treated with Con A and with PTX (200 mg PTX·(kg body mass)(-1)·day(-1), per oral) group. Blood samples and livers were collected at the end of weeks 1, 2, 4, and 8 of Con A treatment. Portal pressure (PP) was measured at the end of week 8. The administration of PTX was found to confer significant protection against the injurious effects of Con A on the liver, by reducing serum levels of aspartate aminotransferase, alanine aminotransferase, hepatic TNF-α, and malondialdehyde. Histopathological examination revealed that treatment with PTX significantly suppressed early inflammation, reduced alpha smooth muscle actin, and the apoptosis of hepatocytes induced by Con A. Moreover, PTX significantly (P < 0.05) reduced PP, and quantitative analyses of the area of fibrosis induced by treatment with Con A showed a significant reduction at the end of week 8. We conclude that rats treated with PTX revealed a more or less normal hepatocyte architecture as well as marked improvement in fibrosis and PP.

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Section: Fig 4 (A-i) Photomicrographs Of Liver Sections From (A) Comentioning

confidence: 97%

Hepatoprotective effects of early pentoxifylline administration on hepatic injury induced by concanavalin A in rat

Mohamed

Elmelegy

El-Aziz

et al. 2014

Can. J. Physiol. Pharmacol.

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Thalidomide but not pentoxifylline lowers portal pressure in human alcoholic cirrhosis

Cited by 1 publication

References 0 publications

Hepatoprotective effects of early pentoxifylline administration on hepatic injury induced by concanavalin A in rat

Hepatoprotective effects of early pentoxifylline administration on hepatic injury induced by concanavalin A in rat

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