Thalidomide as an effective treatment for adult multiple xanthogranuloma

Adult onset xanthogranuloma – case report and review of literature

“…JXG has been described in association with a series of diseases, such as neurofibromatosis type 1 (NF1), Niemann-Pick disease, juvenile myelomonocytic leukemia (JMML), and urticaria pigmentosa (20)(21)(22). The link between JXG and adult onset xanthogranuloma and hematological malignancies is indisputable (6,10). Among the 35 cases of xanthogranuloma occurring in adults reported in the literature, 4 were associated with leukemias, 3 with lymphomas, 1 with myelodysplastic syndrome, 1 with hypereosinophilic myelodysplasia, 1 with a monoclonal gammapathy, and 1 with essential thrombocythemia (6).…”

“…The link between JXG and adult onset xanthogranuloma and hematological malignancies is indisputable (6,10). Among the 35 cases of xanthogranuloma occurring in adults reported in the literature, 4 were associated with leukemias, 3 with lymphomas, 1 with myelodysplastic syndrome, 1 with hypereosinophilic myelodysplasia, 1 with a monoclonal gammapathy, and 1 with essential thrombocythemia (6). Only one case report of adult onset eruptive xanthogranuloma arising in a patient with a solid tumor (gastrointestinal stromal tumor) has been published (23).…”

“…Adult onset xanthogranuloma is exceedingly rare, only 35 cases having been reported so far (6). Patients with multiple cutaneous lesions occurring during adulthood are even rarer.…”

Successful treatment of multiple eruptive adult xanthogranuloma concomitant with xanthelasma palpebrarum with probucol

“…Dear Editor, Xanthogranuloma is common in childhood, but usually regresses spontaneously before school age. 1,2 In contrast, multiple adult xanthogranuloma is rare and tends to be concomitant with internal malignancies such as myelodysplastic syndrome. 3 Only one case of an eruptive xanthogranuloma has been reported in a healthy adult.…”

“…Such lesions include acral pigmented macules associated with Peutz-Jeghers syndrome, anticancer drug-induced hyperpigmentation on the volar skin, subcorneal hemorrhage, pigmented warts, and pigmentation from a dye, such as para-phenylenediamine or a self-tanning product. 1,2 A 47-year-old Japanese woman presented with two oval, black-to-brown macules with well-demarcated borders measuring 10 and 8 mm, respectively, on the right plantar arch (Fig. 1a).…”