Thalamic projections to visual and visuomotor areas (V6 and V6A) in the Rostral Bank of the parieto-occipital sulcus of the Macaque

Gamberini, Michela; Bakola, Sophia; Passarelli, Lauretta; Burman, Kathleen Janis; Rosa, Marcello G. P.; Fattori, Patrizia; Galletti, Claudio

doi:10.1007/s00429-015-0990-2

Cited by 22 publications

(30 citation statements)

References 85 publications

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“…Using the Morel atlas, group-level bilateral thalamic cluster peaks were identified in the ventral/dorsal divisions of the ventral lateral posterior nucleus, rather than the ADN. In macaques, tracer studies show that the ventral lateral region of the thalamus projects to area V6a, a region involved in organizing visual and motor responses (Gamberini et al, 2015). Moreover, human area V6+ shares strong interconnections with V6a, which is sensitive to changes in head orientation (Arnoldussen et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

The Human Retrosplenial Cortex and Thalamus Code Head Direction in a Global Reference Frame

et al. 2016

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Spatial navigation is a multisensory process involving integration of visual and body-based cues. In rodents, head direction (HD) cells, which are most abundant in the thalamus, integrate these cues to code facing direction. Human fMRI studies examining HD coding in virtual environments (VE) have reported effects in retrosplenial complex and (pre-)subiculum, but not the thalamus. Furthermore, HD coding appeared insensitive to global landmarks. These tasks, however, provided only visual cues for orientation, and attending to global landmarks did not benefit task performance. In the present study, participants explored a VE comprising four separate locales, surrounded by four global landmarks. To provide body-based cues, participants wore a head-mounted display so that physical rotations changed facing direction in the VE. During subsequent MRI scanning, subjects saw stationary views of the environment and judged whether their orientation was the same as in the preceding trial. Parameter estimates extracted from retrosplenial cortex and the thalamus revealed significantly reduced BOLD responses when HD was repeated. Moreover, consistent with rodent findings, the signal did not continue to adapt over repetitions of the same HD. These results were supported by a whole-brain analysis showing additional repetition suppression in the precuneus. Together, our findings suggest that: (1) consistent with the rodent literature, the human thalamus may integrate visual and body-based, orientation cues; (2) global reference frame cues can be used to integrate HD across separate individual locales; and (3) immersive training procedures providing full body-based cues may help to elucidate the neural mechanisms supporting spatial navigation.

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Section: Discussionmentioning

confidence: 99%

The Human Retrosplenial Cortex and Thalamus Code Head Direction in a Global Reference Frame

et al. 2016

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“…It has also been shown that TCA secrete FGF from their nerve ends to stimulate proliferation of cortical progenitors, while their projection affects the areal patterning (Dehay et al 2001;Chou et al 2013;Vue et al 2013). Moreover, it has also been hypothesized that the TCA that enter first into the cortical plate would anchor their endpoints, leading to the sulcus formation (Altman & Bayer 2015;Gamberini et al 2016). Thus, TCA are most likely involved in the gyrus formation, but the way they act remains elusive.…”

Section: Gyrus Formationmentioning

confidence: 99%

“…Moreover, it has also been hypothesized that the TCA that enter first into the cortical plate would anchor their endpoints, leading to the sulcus formation (Altman & Bayer ; Gamberini et al . ). Thus, TCA are most likely involved in the gyrus formation, but the way they act remains elusive.…”

Section: Introductionmentioning

confidence: 97%

Developing guinea pig brain as a model for cortical folding

2017

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The cerebral cortex in mammals, the neocortex specifically, is highly diverse among species with respect to its size and morphology, likely reflecting the immense adaptiveness of this lineage. In particular, the pattern and number of convoluted ridges and fissures, called gyri and sulci, respectively, on the surface of the cortex are variable among species and even individuals. However, little is known about the mechanism of cortical folding, although there have been several hypotheses proposed. Recent studies on embryonic neurogenesis revealed the differences in cortical progenitors as a critical factor of the process of gyrification. Here, we investigated the gyrification processes using developing guinea pig brains that form a simple but fundamental pattern of gyri. In addition, we established an electroporation-mediated gene transfer method for guinea pig embryos. We introduce the guinea pig brain as a useful model system to understand the mechanisms and basic principle of cortical folding.

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“…8B ) and subcortical (Gamberini et al, 2015 ) afferences, as well as functional properties, so that it was suggested they work together in the online control of reach-to-grasp actions . In spite of these differences, V6Av and V6Ad also share several cortical ( Fig.…”

Section: Areas V6av and V6admentioning

confidence: 99%

The medial parietal occipital areas in the macaque monkey

2015

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The number, location, extent, and functional properties of the cortical areas that occupy the medial parieto-occipital cortex (mPOC) have been, and still is, a matter of scientific debate. The mPOC is a convoluted region of the brain that presents a high level of individual variability, and the fact that many areas of mPOC are located within very deep sulci further limits the possibility to investigate their anatomo-functional properties. In the present review, we summarize the location and extent of mPOC areas in the macaque brain as obtained by architectural, connectional, and functional data. The different approaches lead to a subdivision of mPOC that includes areas V2, V3, V6, V6Av, and V6Ad. Extrastriate areas V2 and V3 occupy the posterior wall of the parieto-occipital sulcus (POs). The fundus of POs and the ventralmost part of the anterior wall of the sulcus are occupied by a retinotopically organized visual area, called V6, which represents the contralateral part of the visual field and emphasizes its periphery. The remaining part of the anterior wall of POs is occupied by two areas, V6Av and V6Ad, which contain visual as well as arm reaching neurons. Our analyses suggest that areas V6 and V6Av, together, occupy the cortical territory previously described as area PO. Functionally, area V6 is a motion area particularly sensitive to the real motion of objects in the animal's field of view, while V6Av and V6Ad are visuomotor areas likely involved in the visual guidance of arm movement and object prehension.

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Thalamic projections to visual and visuomotor areas (V6 and V6A) in the Rostral Bank of the parieto-occipital sulcus of the Macaque

Cited by 22 publications

References 85 publications

The Human Retrosplenial Cortex and Thalamus Code Head Direction in a Global Reference Frame

The Human Retrosplenial Cortex and Thalamus Code Head Direction in a Global Reference Frame

Developing guinea pig brain as a model for cortical folding

The medial parietal occipital areas in the macaque monkey

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