Thaimycins, new anthelmintic and antiprotozoal antibiotics produced by Streptomyces michiganensis var. amylolyticus var. nova

Cassinelli, Giuseppe; Cotta, Eduardo Adriano; D'Amico, Giovanni; Bruna, C. Della; Grein, A.; Mazzoleni, R.; Ricciardi, M. L.; Tintinelli, R.

doi:10.1007/bf00407710

Cited by 15 publications

(6 citation statements)

References 10 publications

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“…The Streptomyces genus has been the focus of research because of the commercial applicability of substances produced as well as the systematics of this group, which have been modified with advances in molecular biology [24]. Among the species isolated, S. cavourensis is a producer of the antibiotic chromomycin [25] and S. michiganensis is involved in the synthesis of anthelmintic and antiprotozoal substances [26]. …”

Section: Discussionmentioning

confidence: 99%

Brazilian Cerrado Soil Actinobacteria Ecology

Silva

Sales

Magalhães-Guedes

et al. 2013

BioMed Research International

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A total of 2152 Actinobacteria strains were isolated from native Cerrado (Brazilian Savannah) soils located in Passos, Luminárias, and Arcos municipalities (Minas Gerais State, Brazil). The soils were characterised for chemical and microbiological analysis. The microbial analysis led to the identification of nine genera (Streptomyces, Arthrobacter, Rhodococcus, Amycolatopsis, Microbacterium, Frankia, Leifsonia, Nakamurella, and Kitasatospora) and 92 distinct species in both seasons studied (rainy and dry). The rainy season produced a high microbial population of all the aforementioned genera. The pH values of the soil samples from the Passos, Luminárias, and Arcos regions varied from 4.1 to 5.5. There were no significant differences in the concentrations of phosphorus, magnesium, and organic matter in the soils among the studied areas. Samples from the Arcos area contained large amounts of aluminium in the rainy season and both hydrogen and aluminium in the rainy and dry seasons. The Actinobacteria population seemed to be unaffected by the high levels of aluminium in the soil. Studies are being conducted to produce bioactive compounds from Actinobacteria fermentations on different substrates. The present data suggest that the number and diversity of Actinobacteria spp. in tropical soils represent a vast unexplored resource for the biotechnology of bioactives production.

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Section: Discussionmentioning

confidence: 99%

Brazilian Cerrado Soil Actinobacteria Ecology

Silva

Sales

Magalhães-Guedes

et al. 2013

BioMed Research International

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“…Thiamycin complex [73] and myxin [74] [91] while X removed completely majority of the above cestodes at a dose of 125 mg/kg [92]. Better results were reported when X was given to animals in food or water [93,94].…”

Section: Natural Productsmentioning

confidence: 98%

Chemotherapy of cestode infections

Sharma¹,

Dubey²,

Iyer³

1980

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

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“…The thiamycin complex, isolated from the culture of S. michiganensis var. amylolyticus, inhibits Hymenolepis nana when given orally at 25 mg/kg [297]. The broadspectrum antibiotic myxin also has slight activity against H. nana in mice [298].…”

Section: Antibioticsmentioning

confidence: 99%

Progress in the Experimental Chemotherapy of Helminth Infections; Part I, Trematode and Cestode Infections

Islip

1973

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

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Thaimycins, new anthelmintic and antiprotozoal antibiotics produced by Streptomyces michiganensis var. amylolyticus var. nova

Cited by 15 publications

References 10 publications

Brazilian Cerrado Soil Actinobacteria Ecology

Brazilian Cerrado Soil Actinobacteria Ecology

Chemotherapy of cestode infections

Progress in the Experimental Chemotherapy of Helminth Infections; Part I, Trematode and Cestode Infections

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