Thailand orthohantavirus infection in patients with chronic kidney disease of unknown aetiology in Sri Lanka

Yoshimatsu, Kumiko; Gamage, Chandika D.; Sarathkumara, Yomani D.; Kulendiran, Thiviyaaluxmi; Muthusinghe, Devinda S.; Nanayakkara, Nishantha; Gunarathne, Lishanthe; Shimizu, Kenta; Tsuda, Yuichi; Arikawa, Jiro

doi:10.1007/s00705-018-4053-x

Cited by 15 publications

(11 citation statements)

References 23 publications

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“…We reported that anti-THAIV antibodies were detected from sera collected in Girandurukotte in 2016 and these sera were used to select an appropriate serological diagnostic assay [8]. However, THAIV or a THAIV-related hantavirus has not been isolated in Sri Lanka and thus could not be used as a homologous antigen for serological assays.…”

Section: Methodsmentioning

confidence: 99%

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Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study

Sarathkumara

Gamage

Lokupathirage

et al. 2019

Viruses

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Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants’ demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka.

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Section: Methodsmentioning

confidence: 99%

“…We recently reported high seroprevalence of hantaviruses among CKDu patients in Girandurukotte, one of the CKDu hotspots in Sri Lanka [7]. Preliminary findings suggested that Thailand orthohantavirus (THAIV) or a THAIV-related virus was circulating in this area [8]. THAIV was originally isolated in Thailand in 1985 [9].…”

Section: Introductionmentioning

confidence: 99%

Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study

Sarathkumara

Gamage

Lokupathirage

et al. 2019

Viruses

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“…It was recently reported by Gamage et al that 72 (54.5%) out of 132 CKDu patients from the CKDu endemic area of Girandurukotte, Sri Lanka harbored antibodies against hantaviruses [ 21 ]. The existence of THAIV- or THAIV-related hantavirus infections was confirmed by serotyping 89 anti-hantavirus antibody-positive human serum samples obtained from the same area [ 22 ]. Similarly, high levels of antibodies against the hantavirus were reported among CKDu patients from a CKDu hotspot in Polonnaruwa District in the North Central Province of Sri Lanka [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka

Muthusinghe

Shimizu

Lokupathirage

et al. 2021

Viruses

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We reported the genetic evidence of circulating hantaviruses from small mammals captured in a chronic kidney disease of unknown etiology (CKDu) hotspot area of Sri Lanka. The high seroprevalence of anti-hantavirus antibodies against Thailand orthohantavirus (THAIV) has been reported among CKDu patients and rodents in Sri Lankan CKDu hotspots. We captured 116 small mammals from CKDu endemic regions in the Polonnaruwa District of Sri Lanka. Seven animals (five out of 11 Mus booduga and two out of 99 Rattus rattus) were PCR-positive for the hantavirus. A rat-borne sequence was grouped with a THAIV-like Anjozorobe virus. In contrast, Mus-borne sequences belonged to the THAIV lineage, suggesting a novel orthohantavirus species according to the phylogenetic analyses and whole-genome comparisons. Our genetic evidence indicates the presence of two THAIV-related viruses circulating in this CKDu endemic area, suggesting a basis for further investigations to identify the infectious virus in patients with CKDu and the CKDu induction mechanism of these viruses.

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“…As the etiology, there are more than 30 factors, such as drinking water contamination of trace metals/metaloids ( uoride, cadmium, arsenic, lead, uranium, and others) [9,[16][17][18][19][20][21][22][23][24][25][26][27]; hardness of water [28]; mycotoxins [29,30], snake venoms [31][32][33], agrochemicals (insecticides, herbicides, and fertilizers) [34][35][36][37][38][39][40] and dissolved organic matter (DOM) [41]; infection of Thailand orthohantavirus [42,43], leptospirosis [44]; dehydration [45][46][47]; aristolochia [48]; staple diet [49]; and genetic factors [50], have been investigated. Recent retrospective and prospective studies suggested that in addition to the geogenic components, disease manifestation requires (A) prolonged exposure to environmental nephrotoxins and factors, (B) interactions among ions (Ca 2+ , PO 4 − 3 , F − , and Mg 2+ ), and (C) vulnerabilities of the person, such as chronic dehydration, antioxidant and micronutrient de ciencies [51][52][53].…”

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confidence: 99%

Urinary Concentrations of Neonicotinoid Insecticides in Chronic Kidney Disease Patients, Their Family Members and Others in Dry-Zone of Sri Lanka

Taira

Kawakami

Weragoda

et al. 2021

Preprint

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The growing worldwide prevalence of chronic kidney disease of unknown etiology (CKDu) has been reported since the 1990’s. Neonicotinoids are systemic insecticides used since 1990’s, which may cause renal dysfunction, but the effect on the urinary concentration was unknown. We conducted a field-based case-control study in the North Central Dry-zone of Sri Lanka where CKDu was prevailing. We collected spot urine samples from15 CKD patients, 15 CKD family members, and 62 neighbors in May and December 2015, analyzed seven neonicotinoids and a metabolite by LC-ESI/MS/MS, in addition to two biomarkers of renal tubule activity, Cystatin-C and L-FABP. We also investigated their symptoms using a questionnaire. In CKD patients, urine Cystatin-C and L-FABP were significantly higher compared to non-CKD participants; and they complained of finger tremor, fever, and abnormal behavior more. Among neonicotinoids, N-desmethyl-acetamiprid was detected at the highest rate in 92.4 %, followed by thiamethoxam in 17.4%. Dinotefuran and thiacloprid that was not registered since 2015 in Sri Lanka were detected in 17.4%, 3.3%, respectively. In the participants whose urine Cystatin-C was in higher half, N-desmethyl-acetamiprid was significantly less than others. The urine neonicotinoid levels in CKD patients with compromised tubular function doesn’t seem to reflect their level of exposure.

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Thailand orthohantavirus infection in patients with chronic kidney disease of unknown aetiology in Sri Lanka

Cited by 15 publications

References 23 publications

Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study

Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study

Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka

Urinary Concentrations of Neonicotinoid Insecticides in Chronic Kidney Disease Patients, Their Family Members and Others in Dry-Zone of Sri Lanka

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