Th1 Th2, Tc1 Tc2 cells of patients with otolaryngological diseases

Ohta, Nobuo; Fukase, Shigeru; Fuse, Takeo; Aoyagi, Masaru

doi:10.1111/j.1440-1592.2004.00335.x

Cited by 7 publications

(7 citation statements)

References 39 publications

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Section: Introductionmentioning

confidence: 99%

“…Recent studies have reported that T helper (Th) cells can be subdivided into mutually exclusive Th1 (producing especially interleukin 2 [IL‐2] and interferon gamma [IFN‐γ]) and Th2 (producing especially IL‐4, IL‐5, IL‐9, IL‐10, and IL‐13) subsets 8, 9, 10. Th1 cells are primarily involved in cell‐mediated immune responses, whereas Th2 cells fulfill an important role in humoral and allergic immune responses 8, 9, 10. Similarly, CD8 + T cells have recently been subdivided into CD8 + T cells secreting cytokines in a Th1‐like pattern (T cytotoxic type 1 [Tc1] cells), versus CD8 + T cells secreting cytokines in a Th2‐like pattern (Tc2 cells) 8, 9, 10…”

Section: Introductionmentioning

confidence: 99%

“…Th1 cells are primarily involved in cell‐mediated immune responses, whereas Th2 cells fulfill an important role in humoral and allergic immune responses 8, 9, 10. Similarly, CD8 + T cells have recently been subdivided into CD8 + T cells secreting cytokines in a Th1‐like pattern (T cytotoxic type 1 [Tc1] cells), versus CD8 + T cells secreting cytokines in a Th2‐like pattern (Tc2 cells) 8, 9, 10…”

Section: Introductionmentioning

confidence: 99%

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Roles of IL‐17, Th1, and Tc1 cells in patients with IgG4‐related sclerosing sialadenitis

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Roles of IL‐17, Th1, and Tc1 cells in patients with IgG4‐related sclerosing sialadenitis

et al. 2012

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“…Tc1 cells secrete a Th1-type cytokine pattern, including IL-2 and IFN-γ, whereas Tc2 cells produce Th2-like cytokines, including IL-4, IL-5 and IL-10, (DELFS et al, 2001;OHTA et al, 2004). In rats infected with L. infantum, CD8+ T cells isolated expressed IFN-γ and TNF, improving the cellular cytotoxic activity against Leishmania spp., suggesting that CD8+ T-cells displayed a Tc1 pattern of differentiation, which was important for the control of the parasite (TSAGOZIS et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…In rats infected with L. infantum, CD8+ T cells isolated expressed IFN-γ and TNF, improving the cellular cytotoxic activity against Leishmania spp., suggesting that CD8+ T-cells displayed a Tc1 pattern of differentiation, which was important for the control of the parasite (TSAGOZIS et al, 2003). For Ohta et al (2004) there is increasing evidence that Th1/Th2 and Tc1/Tc2 mediated cytokine imbalance has been of pathogenetic importance in various diseases, such as allergic and autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

T lymphocytes and macrophages in the intestinal tissues of dogs infected with Leishmania infantum

Silva

Alves

Spada

et al. 2017

Rev. Bras. Parasitol. Vet.

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This study was about a semi-quantitative analysis of T lymphocytes (CD4 + and CD8 + , FoxP3 + regulatory T cells), and macrophages in the gut wall of dogs naturally infected with Leishmania infantum. Thirteen dogs were divided into three groups: group 1 (G1, n=5), dogs with canine visceral leishmaniasis (CVL) and infected with L. infantum amastigotes in the intestine; group 2 (G2, n=5), dogs with CVL but without intestinal amastigotes; and group 3 (G3, n=3), uninfected dogs (control group). There was no significant difference (p ≥ 0.05) on CD4 + and Treg cell numbers among the groups, whereas the levels of CD8 + T cells and macrophages were significantly higher in dogs from G1 group than in G2 and G3 (p ≤ 0.05), especially in intestinal segments with high parasite burden. Parasite burden correlated positively with levels of CD8 + T cells and macrophages (p ≤ 0.05), but was inversely correlated to levels of CD4 + T lymphocytes and FoxP3 + Treg cells. In conclusion, in the intestine of dogs with CVL, the increase of CD8 + T cells and macrophages population associated with high parasite burdens, but no changes of CD4 + T cells and FoxP3 + Treg cells suggest a possible immunoregulation by the parasite not dependent on Treg cells.Keywords: T lymphocytes, macrophages, canine visceral leishmaniasis, intestinal tract. ResumoEste estudo foi uma análise semi-quantitativa de linfócitos T (CD4 + , CD8 + e regulatórios -Treg FoxP3 + ) e macrófagos na parede intestinal de cães naturalmente infectados com Leishmania infantum. Treze cães foram divididos em três grupos: grupo 1 (G1, n=5) continha cães com leishmaniose visceral canina (LVC) e com amastigotas intestinais; grupo 2 (G2, n=5) continha cães com LVC, mas sem amastigotas intestinais e o grupo 3 (G3, n=3) continha cães não infectados (grupo controle). Verificou-se que não houve diferença significativa (p ≤ 0.05) no número de células CD4 + e de Treg entre os grupos, mas o número de células T CD8 + e macrófagos foi significativamente superior nos cães do grupo G1 em relação ao G2 e ao G3 (p ≤ 0,05), especialmente nos segmentos intestinais com altas cargas parasitárias. As altas cargas parasitarias correlacionaram positivamente com os números de CD8 + e macrófagos (p ≤ 0,05), mas negativamente com as células CD4 + e Treg. Em conclusão, no intestino dos cães com LVC, o aumento das populações de células T CD8 + e de macrófagos associado a altas cargas parasitárias, mas nenhuma alteração de células T CD4 + e células Treg FoxP3 + sugerem uma possível imunorregulação pelo parasita não dependente de células Treg.Palavras-chave: Linfócito T, macrófagos, leishmaniose visceral canina, trato intestinal.

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