TH1/TH17 cell recognition of desmoglein 3 and bullous pemphigoid antigen 180 in patients with lichen planus

Secukinumab for patients with plaque psoriasis affected by multiple sclerosis: a mini‐review with a representative case report

“…The disease may however also occur several months after ICB discontinuation. 3,8 These findings may explain the phenotype observed in our first patient showing concomitantly a cutaneous lichenoid and an oral subepithelial blistering dermatosis and further raise the question about the nosologic relationship of our first case with lichen planus pemphigoides as well as a new subtype of MMP with oral lichen features. 1 Murphy mice characterized by a Tregs dysfunction develop both a lichenoid interface dermatitis and an autoantibody response to BP180 and BP230.…”

“…Lichen planus (LP) patients have also been found to have an autoreactive T cells against BP180, the major target antigen of BP and MMP. 3,8 These findings may explain the phenotype observed in our first patient showing concomitantly a cutaneous lichenoid and an oral subepithelial blistering dermatosis and further raise the question about the nosologic relationship of our first case with lichen planus pemphigoides as well as a new subtype of MMP with oral lichen features. 3,9 Hence, autoimmune blistering and lichenoid dermatoses, as…”

Mucous membrane pemphigoid of the oral lichen type: a retrospective analysis of 16 cases

“…7 These observations imply that dysfunction of Treg cells results in both autoreactive cytotoxic T cells as well as generation of autoantibodies to the same antigenic targets. 6,7 We therefore speculate that a subset of patients with MMP have a mixed cellular and humoral immune response directed against hemidesmosomal components,…”

“…In OLP, damage of basement membrane zone due to the cellular lichenoid reaction is thought to result in the exposure of antigens sequestered within the hemidesmosomal adhesion complex, leading to an autoantibody response. 1,5 Schmidt et al 6 showed that patients with lichen planus (LP) have a Th1/Th17 cell response against both desmoglein 3 and BP180. Specifically, LP patients show an increased peripheral blood mixed Th1/Th17 cell response against BP180.…”

“…In analogy, bullous pemphigoid patients have also autoreactive BP180-peripheral Th2 cells, which are thought to critically regulate the IgG autoantibody response. 6 Furthermore, murphy mice showing Treg cell dysfunction caused by FOXP3 mutations develop after birth both a lichenoid interface dermatitis and tissue-bound and circulating autoantibodies directed against BP180 and BP230. 7 These observations imply that dysfunction of Treg cells results in both autoreactive cytotoxic T cells as well as generation of autoantibodies to the same antigenic targets.…”