Mucous membrane pemphigoid of the oral lichen type: a retrospective analysis of 16 cases

Benzaquen, Michael; Suter, Valérie G.A.; Gschwend, Michael H.; Feldmeyer, Laurence; Borradori, Luca

doi:10.1111/jdv.15473

Cited by 15 publications

(14 citation statements)

References 6 publications

(6 reference statements)

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“…MMP can mimic lichen planus clinically with reticular and atrophic patterns and histologically with interface dermatitis. DIF is essential in distinguishing these disease …”

Section: Mucous Membrane Pemphigoidmentioning

confidence: 99%

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Review of autoimmune blistering diseases: the Pemphigoid diseases

Daniel

Murrell

2019

Acad Dermatol Venereol

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Autoimmune Blistering Diseases of the Pemphigoid type is characterised by sub‐epidermal blisters (SEB) with circulating autoantibodies against components of the basement membrane zone (BMZ). The main disorders to date include bullous pemphigoid (BP), pemphigoid gestationis, mucous membrane pemphigoid (MMP), epidermolysis bullosa acquisita (EBA), linear IgA disease (LABD), dermatitis herpetiformis (DH), lichen planus pemphigoides and bullous lupus. This is in contrast to pemphigus and related disorders, which demonstrate intraepidermal acantholysis and a positive Nikolsky sign. The classification and management is based on clinical, histological and direct and indirect immunofluorescence findings. There are, however, overlapping clinical and histological features between the conditions and clinical heterogeneity within each disease.

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“…MMP can mimic lichen planus clinically with reticular and atrophic patterns and histologically with interface dermatitis. DIF is essential in distinguishing these disease …”

Section: Mucous Membrane Pemphigoidmentioning

confidence: 99%

“…DIF is essential in distinguishing these disease. 74 The Brunsting Perry variant is characterized by bullae on the head and neck with mild or no mucosal involvement. Scalp involvement leads to scarring alopecia.…”

Section: Mucous Membrane Pemphigoidmentioning

confidence: 99%

Review of autoimmune blistering diseases: the Pemphigoid diseases

Daniel

Murrell

2019

Acad Dermatol Venereol

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“…5 Immune checkpoint inhibitor therapy with anti-programmed death-1/ programmed death-ligand 1 results in a breakdown of tolerance, reduces activity of regulatory T cells (Tregs) and activates B cells and autoreactive T cells. 3,9 Hence, autoimmune blistering and lichenoid dermatoses, as 7 Hence, Tregs blockade may result in both autoreactive cellular and humoral response to the same antigenic targets of the epidermal and epithelial BMZ.…”

Section: Mucous Membrane Pemphigoid and Lichenoid Reactions After Immmentioning

confidence: 99%

Secukinumab for patients with plaque psoriasis affected by multiple sclerosis: a mini‐review with a representative case report

Venturini

Zanca

Venturuzzo

et al. 2019

Acad Dermatol Venereol

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remain high on the differential diagnosis. 2,8 Notably, peristomal skin complications are reported as high as 67%, and almost all patients with an ostomy experience some degree of irritant dermatitis. 2,9 Applying proper wound care principles to address devitalized tissue, infection and moisture imbalance are vital in the treatment of these other conditions. 10 We believe our patients' symptoms initially developed as an irritant dermatitis but were further exacerbated by poor wound healing and chronic irritation. If the clinical suspicion for PPG is low, we encourage an initial trial of aggressive wound care. After initiating proper wound care, clinical improvement without the use of immunosuppressants should raise suspicion for other common aetiologies of peristomal ulceration.

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“…Other causes of mucosal erosions and ulcerations include other AIBD, such as laminin γ‐1 pemphigoid and epidermolysis bullosa acquisita, Stevens–Johnson syndrome, erythema multiforme and erosive lichen planus (LP) . Of note, cases of oral MMP with clinical and histopathological characteristics of oral LP have been highlighted recently . Moreover, coexistence of lichenoid mucositis with acantholysis is typically found in paraneoplastic pemphigus .…”

mentioning

confidence: 99%

“…6,7 Of note, cases of oral MMP with clinical and histopathological characteristics of oral LP have been highlighted recently. 8 Moreover, coexistence of lichenoid mucositis with acantholysis is typically found in paraneoplastic pemphigus. 2 Thus, although an accurate clinical examination and histopathology are paramount in raising a clinical suspicion of an oral AIBD, the diagnosis is based on the demonstration of tissue-bound IgG autoantibodies which target the epithelium or the DEJ of lesional mucosal tissue and/or the detection of circulating IgG autoantibodies in the patient's sera, and possibly, the identification of the targeted antigen.…”

mentioning

confidence: 99%