Th 1-type immunity is incompatible with successful pregnancy

Raghupathy, Raj

doi:10.1016/s0167-5699(97)01127-4

Cited by 927 publications

(615 citation statements)

References 41 publications

Supporting

Mentioning

566

Contrasting

Unclassified

Order By: Relevance

“…It is widely recognized that cytokines play a fundamental role at the maternal/fetal interface in early human pregnancy, and that cytokine dysregulation must be linked to pregnancy wastage. [2][3][4][5]26 For many years, it has been believed that the predominance of Th2-type cytokines, such as IL-4 and IL-10, over Th1-type cytokines, such as IFN-c and TNF-a, at the maternal/ fetal interface was fundamental for a successful pregnancy. [2][3][4] However, the potential mechanism of development of Th2 bias at the maternal/fetal interface remains unclear.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy

Piao

Zhu

et al. 2012

Cell Mol Immunol

View full text Add to dashboard Cite

The regulatory mechanism of Th2 bias at the maternal/fetal interface remains unclear. In this study, we characterized cytokine production in decidual stromal cells (DSCs), decidual immune cells (DICs) and embryo-derived trophoblast cells, and investigated the regulation of CXCL12/CXCR4 interaction on Th2 bias at the maternal/fetal interface in early human pregnancy. We found differential production of Th1-type and Th2-type cytokines by trophoblasts, DSCs and DICs. The secretion of these cytokines varied in different cell cocultures, conduced to Th2 bias. Flow cytometry showed that coculture of trophoblasts with DSCs and DICs significantly increased IL-4 and IL-10 production in trophoblasts, and IL-10 production in DSCs. However, the coculture of trophoblasts with DSCs and DICs significantly increased interferon (IFN)-c expression in DSCs, and tumor-necrosis factor (TNF)-a expression in DICs. No change was seen in Th1-type cytokine production in trophoblasts, and in Th2-type cytokine production in DICs in all cocultures. Furthermore, pre-treatment with anti-CXCR4 neutralizing antibody upregulated the production of the Th1-type cytokines IFN-c and TNF-a, and downregulated the production of the Th2-type cytokines IL-4 and IL-10, in trophoblasts, DSCs, DICs or their cocultures. Interestingly, rhCXCL12 inhibited production of the Th1-type cytokine TNF-a and enhanced the expression of the Th2-type cytokines such as IL-4 and IL-10 in DICs; this effect was abrogated by anti-CXCR4 antibody. Our present study has elucidated the individual contributions of component cells to the shaping of Th2 bias, and uncovered a complicated cross-talk via the CXCL12/CXCR4 signal at the maternal/fetal interface in early human pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

“…It has been confirmed that Th2 bias is present at the maternal/fetal interface and in the periphery of successful pregnancy, and that a Th1 bias at the maternal/fetal interface is associated with pregnancy wastage. [1][2][3][4][5] However, how the Th2 bias is developed and maintained at the maternal/fetal interface is still undefined.…”

Section: Introductionmentioning

confidence: 99%

The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy

Piao

Zhu

et al. 2012

Cell Mol Immunol

View full text Add to dashboard Cite

show abstract

“…Recently, a 34 kDa progesterone-induced blocking factor (PIBF) has been detected in sera from pregnant women [38]. PIBF seems to modulate the Th1/Th2 balance by inducing production of Th2-type cytokines [39], that are considered as essential in maintaining a successful pregnancy [40].…”

Section: Discussionmentioning

confidence: 99%

Suppression of Immunoglobulin Secretion by Soluble Annexin II

Aarli

Matre

1998

Scand J Immunol

View full text Add to dashboard Cite

Aarli Å , Matre R. Suppression of Immunoglobulin Secretion by Soluble Annexin II. Scand J Immunol 1998;48:522-526 Annexin II (AII) belongs to a family of glycoproteins that bind negatively charged phospholipids in the presence of calcium. The annexins exert various biological functions. We have previously shown that soluble AII suppresses mitogen-induced lymphoproliferation in vitro. In this study we address the question of whether soluble AII may also affect immunoglobulin secretion. Mononuclear cells from peripheral blood were stimulated with pokeweed mitogen in vitro and immunoglobulin-secreting cells were quantified using an ELISPOT assay. Retroplacental serum and soluble AII significantly inhibited secretion of IgG and IgM when added at concentrations that did not affect lymphoproliferation or cell viability. The inhibitory effect was dose-and time dependent. Significant suppression was observed when soluble AII was added at concentrations of 0.1 and 0.01 mg/ml. The strongest inhibition was observed when soluble AII or retroplacental serum was added initially. The data demonstrate that soluble AII can suppress immunoglobulin secretion in vitro. AII seems to be a potent immunosuppressive substance. The presence of high levels of soluble AII in retroplacental serum may indicate a possible immunomodulatory role in normal pregnancy.

show abstract

“…Immune disturbances can be most conclusively linked to implantation failure and trophoblast rejection in women [97], both of which are the basis of pregnancy pathologies such as pre-eclampsia and recurrent spontaneous abortion. There is good evidence that a strong Th1 response leading to detrimental cell-mediated immunity is deleterious to pregnancy outcome [98], where as a Th2 response resulting in a humoral immune response is seen as more favourable for a positive outcome [99]. The overall phenotype and proportion of lymphocytes is also thought to play a role in pathologies such as spontaneous abortion.…”

Section: Seminal Plasma and Pathologies Of Pregnancymentioning

confidence: 99%

Seminal fluid and reproduction: much more than previously thought

Bromfield

2014

J Assist Reprod Genet

123

View full text Add to dashboard Cite

The influence of seminal plasma on the cytokine and immune uterine environment is well characterised in mice and humans, while the effects of disruption to uterine seminal plasma exposure on pregnancy and offspring health is becoming more clearly understood. The cellular and molecular environment of the uterus during the pre-and peri-implantation period of early pregnancy is critical for implantation success and optimal foetal and placental development. Perturbations to this environment not only have consequences for the success of pregnancy and neonatal health and viability, but can also drive adverse health outcomes in the offspring after birth, particularly the development of metabolic disorders such as obesity, hypertension and insulin resistance. It is now reported that an absence of seminal plasma at conception in mice promotes increased fat accumulation, altered metabolism and hypertension in offspring. The evidence reviewed here demonstrates that seminal plasma is not simply a transport medium for sperm, but acts also as a key regulator of the female tract environment providing optimal support for the developing embryo and benefiting future health of offspring.

show abstract

Th 1-type immunity is incompatible with successful pregnancy

Cited by 927 publications

References 41 publications

The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy

The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy

Suppression of Immunoglobulin Secretion by Soluble Annexin II

Seminal fluid and reproduction: much more than previously thought

Contact Info

Product

Resources

About