Seminal fluid and reproduction: much more than previously thought

Bromfield, John J.

doi:10.1007/s10815-014-0243-y

Cited by 118 publications

(100 citation statements)

References 110 publications

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“…62 While fathers cannot provide direct nourishment to the young after birth, additional attention should be paid to whether a healthy diet of the father, and the mother, before conception can lead to long-term beneficial offspring consequences. It is increasingly becoming apparent that sub-optimal paternal diets, those high in fat or protein restricted, can result in negative offspring sequelae, [14][15][16][17][18][19][20][21][146][147][148][149] but the impacts of a healthy diet have been largely ignored. In conclusion, much work remains on identifying various steps that both parents can adapt to ensure the lifelong health of their offspring and potentially even triumph over negative influences that the conceptus or neonate may encounter.…”

Section: Discussionmentioning

confidence: 99%

Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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Abundant evidence exists linking maternal and paternal environments from pericopconception through the postnatal period to later risk to offspring diseases. This concept was first articulated by the late Sir David Barker and as such coined the Barker Hypothesis. The term was then mutated to Fetal Origins of Adult Disease and finally broadened to developmental origins of adult health and disease (DOHaD) in recognition that the perinatal environment can shape both health and disease in resulting offspring. Developmental exposure to various factors, including stress, obesity, caloric-rich diets and environmental chemicals can lead to detrimental offspring health outcomes. However, less attention has been paid to date on measures that parents can take to promote the long-term health of their offspring. In essence, have we neglected to consider the ‘H’ in DOHaD? It is the ‘H’ component that should be of primary concern to expecting mothers and fathers and those seeking to have children. While it may not be possible to eliminate exposure to all pernicious factors, prevention/remediation strategies may tip the scale to health rather than disease. By understanding disruptive DOHaD mechanisms, it may also illuminate behavioral modifications that parents can adapt before fertilization and throughout the neonatal period to promote the lifelong health of their male and female offspring. Three possibilities will be explored in the current review: parental exercise, probiotic supplementation and breastfeeding in the case of mothers. The ‘H’ paradigm should be the focus going forward as a healthy start can indeed last a lifetime.

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Section: Discussionmentioning

confidence: 99%

Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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“…In this background, seminal plasma contains oestrogen, testosterone, prostaglandins and signalling substances, including cytokines and growth factors known to recruit and activate macrophages, granulocytes. Semen contains four main prostaglandins (PGs) of the E series, namely PGE1, PGE2, 19-OH PGEI and 19-OH PGE2 (Bromfield, 2014;Remes Lenicov et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Seminal cyclooxygenase relationship with oxidative stress in infertile oligoasthenoteratozoospermic men with varicocele

Mostafa

Rashed

Taymour³

2015

Andrologia

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This study aimed to assess the relation of seminal cyclooxygenase COX-1, COX-2 with oxidative stress in infertile oligoasthenoteratozoospermic (OAT) men with varicocele (Vx). In all, 128 men were allocated into fertile men, fertile men with Vx, infertile OAT men without Vx and infertile OAT men with Vx. They were subjected to history taking, clinical examination and semen analysis. Also, seminal COX-1, COX-2, malondialdehyde (MDA) and glutathione peroxidase (GPx) were estimated. Mean levels of seminal COX-1, COX-2 were over-expressed, the mean level of seminal MDA was significantly increased, and the mean level of seminal GPx was significantly decreased in infertile OAT men with Vx compared with other groups. Seminal COX-1 and COX-2 were over-expressed in cases with Vx grade III compared with Vx grades I, II cases and in cases with bilateral Vx compared with unilateral Vx. There was significant negative correlation between seminal COX-1 and COX-2 with sperm concentration, sperm motility, sperm normal morphology, seminal GPx and significant positive correlation with seminal MDA. It is concluded that seminal COX-1 and COX-2 are over-expressed in infertile OAT men with Vx compared with fertile men with/without and infertile OAT men without Vx being associated with oxidative stress, Vx grade and Vx laterality.

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“…; Perry et al . ), and can influence offspring health via effects on the female reproductive tract (Bromfield ; Bromfield et al . ).…”

Section: Introductionmentioning

confidence: 99%

Revisiting telegony: offspring inherit an acquired characteristic of their mother's previous mate

2014

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Newly discovered non-genetic mechanisms break the link between genes and inheritance, thereby also raising the possibility that previous mating partners could influence traits in offspring sired by subsequent males that mate with the same female (‘telegony’). In the fly Telostylinus angusticollis, males transmit their environmentally acquired condition via paternal effects on offspring body size. We manipulated male condition, and mated females to two males in high or low condition in a fully crossed design. Although the second male sired a large majority of offspring, offspring body size was influenced by the condition of the first male. This effect was not observed when females were exposed to the first male without mating, implicating semen-mediated effects rather than female differential allocation based on pre-mating assessment of male quality. Our results reveal a novel type of transgenerational effect with potential implications for the evolution of reproductive strategies.

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Seminal fluid and reproduction: much more than previously thought

Cited by 118 publications

References 110 publications

Homage to the ‘H’ in developmental origins of health and disease

Homage to the ‘H’ in developmental origins of health and disease

Seminal cyclooxygenase relationship with oxidative stress in infertile oligoasthenoteratozoospermic men with varicocele

Revisiting telegony: offspring inherit an acquired characteristic of their mother's previous mate

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