Transforming Growth Factor-Β in Cancer Therapy, Volume II 2008
DOI: 10.1007/978-1-59745-293-9_21
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TGFβ: Roles in DNA Damage Responses

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Cited by 5 publications
(4 citation statements)
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“…Network analysis of the IHC-156 revealed TGFβ hubs and enrichment of TGFβ mediated genes. Our earlier functional studies showed that radiation-induced TGFβ activation in vivo mediates extracellular matrix remodeling, cell fate decisions, ATM kinase control of the DNA damage response, and EMT (reviewed in (Andarawewa et al, 2007)). Expression analysis of irradiated Tgfb1 heterozygote and wild type mammary gland further underscored the considerable influence of TGFβ in the tissue response to radiation and motivated the radiation chimera experiment using Tgfb1 heterozygote hosts.…”
Section: Discussionmentioning
confidence: 99%
“…Network analysis of the IHC-156 revealed TGFβ hubs and enrichment of TGFβ mediated genes. Our earlier functional studies showed that radiation-induced TGFβ activation in vivo mediates extracellular matrix remodeling, cell fate decisions, ATM kinase control of the DNA damage response, and EMT (reviewed in (Andarawewa et al, 2007)). Expression analysis of irradiated Tgfb1 heterozygote and wild type mammary gland further underscored the considerable influence of TGFβ in the tissue response to radiation and motivated the radiation chimera experiment using Tgfb1 heterozygote hosts.…”
Section: Discussionmentioning
confidence: 99%
“…Recent data suggest an even more proximal role for TGFβ in radiotherapy (reviewed in [ 64 ]). Breast cancer radiotherapy targets the tumor with the goal of inducing DNA damage resulting in cancer cell death, which increases long term patient survival [ 65 ].…”
Section: Tgfβ a Malicious Bystander During Cancer Therapymentioning
confidence: 99%
“…There is substantial evidence that TGFβ plays a crucial role in the response to ionizing radiation (2). TGFβ is a pleio-tropic cytokine that is important in normal tissue homeo-stasis, regulates inflammation and immune responses, and suppresses epithelial proliferation.…”
Section: Introductionmentioning
confidence: 99%
“…A new role for TGFβ in mediating the rapid execution of the DNA damage response (DDR) has been identified (reviewed in ref 2). Perhaps the first indication of its critical role was the observation that epithelial tissues of Tgfb1 heterozygote embryos exposed in utero to 5 Gy showed significantly less radiation-induced apoptosis and Tgfb1 null embryos fail to undergo either apoptosis or inhibition of cell cycle (17).…”
Section: Introductionmentioning
confidence: 99%