TGFB3-AS1 promotes Hcy-induced inflammation of macrophages via inhibiting the maturity of miR-144 and upregulating Rap1a

Zhang, Hui; Hao, Yinju; Ai, Yang; Xie, Lin; Ding, Ning; Xu, Lingbo; Wang, Yanhua; Yang, Yong; Bai, Yongsheng; Zhang, Huiping; Jiang, Yideng

doi:10.1016/j.omtn.2021.10.031

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…Functional associations of miR-144-3p and -5p predicted targets included terms involving cytokine and growth factor response-pathways consistent with the systemic inflammation characterizing severe COVID-19 disease 5,6 . Indeed, evidence of a direct impact of miR-144-3p on inflammatory pathways has been documented www.nature.com/scientificreports/ both in LPS-induced cardiomyocyte injury 48 and in macrophages 49,50 . Also relevant is miR-144-3p mediated protection against LPS-induced hyperpermeability of lung endothelial cells 51 .…”

Section: Discussionmentioning

confidence: 99%

Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality

Madè

Greco

Vausort

et al. 2022

Sci Rep

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Coronavirus disease-2019 (COVID-19) can be asymptomatic or lead to a wide symptom spectrum, including multi-organ damage and death. Here, we explored the potential of microRNAs in delineating patient condition and predicting clinical outcome. Plasma microRNA profiling of hospitalized COVID-19 patients showed that miR-144-3p was dynamically regulated in response to COVID-19. Thus, we further investigated the biomarker potential of miR-144-3p measured at admission in 179 COVID-19 patients and 29 healthy controls recruited in three centers. In hospitalized patients, circulating miR-144-3p levels discriminated between non-critical and critical illness (AUCmiR-144-3p = 0.71; p = 0.0006), acting also as mortality predictor (AUCmiR-144-3p = 0.67; p = 0.004). In non-hospitalized patients, plasma miR-144-3p levels discriminated mild from moderate disease (AUCmiR-144-3p = 0.67; p = 0.03). Uncontrolled release of pro-inflammatory cytokines can lead to clinical deterioration. Thus, we explored the added value of a miR-144/cytokine combined analysis in the assessment of hospitalized COVID-19 patients. A miR-144-3p/Epidermal Growth Factor (EGF) combined score discriminated between non-critical and critical hospitalized patients (AUCmiR-144-3p/EGF = 0.81; p < 0.0001); moreover, a miR-144-3p/Interleukin-10 (IL-10) score discriminated survivors from nonsurvivors (AUCmiR-144-3p/IL-10 = 0.83; p < 0.0001). In conclusion, circulating miR-144-3p, possibly in combination with IL-10 or EGF, emerges as a noninvasive tool for early risk-based stratification and mortality prediction in COVID-19.

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Section: Discussionmentioning

confidence: 99%

Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality

Madè

Greco

Vausort

et al. 2022

Sci Rep

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“…LncRNAs can act as negative regulators of miRNA biogenesis, revealing a novel mechanism of lncRNA-miRNA crosstalk. [38][39][40][41] HOXC-AS3 has been reported to suppress the maturation of miR-96 by inhibiting the transportation of premature miR-96 from the nucleus to the cytoplasm in ovarian and lung cancer cells. 13,35 One crucial lncRNA mechanism is acting as a competing endogenous RNA (ceRNA), [42][43][44] sequestering miRNAs from their target mRNAs and forming a lncRNA-miRNA-mRNA network.…”

Section: The Role Of Hoxc-as3 and Its Regulatory Mechanisms In Variou...mentioning

confidence: 99%

HOXC Cluster Antisense RNA 3, a Novel Long Non-Coding RNA as an Oncological Biomarker and Therapeutic Target in Human Malignancies

Xie,

Ye,

Luo

2023

OTT

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HOXC cluster antisense RNA 3 (HOXC-AS3) is a novel long noncoding RNA (lncRNA) that exhibits aberrant expression patterns in various cancer types. Its expression is closely related to clinicopathological features, demonstrating significant clinical relevance across multiple tumors. And HOXC-AS3 plays multifaceted roles in tumor progression, impacting cell proliferation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT), autophagy, senescence, tumor growth, and metastasis. In this review, we summarized and comprehensively analyzed the expression and clinical significance of HOXC-AS3 as a diagnostic and prognostic biomarker for malignancies. Additionally, we presented an in-depth update on HOXC-AS3’s functions and regulatory mechanisms in cancer pathogenesis. This narrative review underscores the importance of HOXC-AS3 as a promising lncRNA candidate in cancer research and its potential as a predictive biomarker and therapeutic target in clinical applications.

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Hcy accelerates the biological dysfunction of ANA-1 macrophages and vascular injure via Rap1A/MAPK signal

Huang,

Yang,

Wang

et al. 2024

Preprint

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Hyperhomocysteinemia (HHcy) is a kind of risk factor for various vascular diseases. The dysfunction of macrophages plays a crucial role in the development of HHcy-aggravated vascular injury. However, macrophages injure is still unclear. In this study, we propose the hypothesis that the Rap1A/ERK1/2 signal pathway is responsible for mediating the dysfunction of macrophages in HHcy-induced vascular diseases. We found that Cell proliferation, migration and invasion ability were increased after Hcy treatment. In addition, the mRNA levels of CD80 and CD86, and protein expression of Rap1A, iNOS were also increased in Hcy group. Interference of Rap1A reversed Hcy-induced cell proliferation, migration and invasion, and also reduced macrophage inflammatory response and M1 polarization. Phosphorylation of ERK1/2 was inhibited after Rap1A knockdown. Suppression of ERK1/2 alleviated Hcy-induced macrophage dysfunction. Together, Rap1A mediates Hcy-induced macrophage dysfunction via ERK1/2 signaling, which highlights a new mechanism in the pathogenesis and development of HHcy-aggravated vascular diseases.

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TGFB3-AS1 promotes Hcy-induced inflammation of macrophages via inhibiting the maturity of miR-144 and upregulating Rap1a

Cited by 4 publications

References 48 publications

Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality

Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality

HOXC Cluster Antisense RNA 3, a Novel Long Non-Coding RNA as an Oncological Biomarker and Therapeutic Target in Human Malignancies

Hcy accelerates the biological dysfunction of ANA-1 macrophages and vascular injure via Rap1A/MAPK signal

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