Hcy accelerates the biological dysfunction of ANA-1 macrophages and vascular injure via Rap1A/MAPK signal
Xiaobo Huang,
Yali Yang,
Lexin Wang
et al.
Abstract:Hyperhomocysteinemia (HHcy) is a kind of risk factor for various vascular diseases. The dysfunction of macrophages plays a crucial role in the development of HHcy-aggravated vascular injury. However, macrophages injure is still unclear. In this study, we propose the hypothesis that the Rap1A/ERK1/2 signal pathway is responsible for mediating the dysfunction of macrophages in HHcy-induced vascular diseases. We found that Cell proliferation, migration and invasion ability were increased after Hcy treatment. In a… Show more
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