Texturing Silicon Nanowires for Highly Localized Optical Modulation of Cellular Dynamics

Fang, Yin; Jiang, Yuanwen; Ledesma, Héctor Acarón; Yi, Jaeseok; Gao, Xiang; Weiss, Dara E.; Shi, Fengyuan; Tian, Bozhi

doi:10.1021/acs.nanolett.8b01626

Cited by 53 publications

(52 citation statements)

References 39 publications

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“…Size modulation such as decreasing diameter and material thicknesses is commonly used to achieve conformability enabled by strain engineering . In neuron activity recording, electrodes with the neuron‐like dimensions shows reduced mechanical stiffness by 5–20 times compared to reported flexible probes, which allows the probing and modulation of electrical and chemical signals at subcellular scale (Figure b) . Decreasing thickness is widely used as bending strains are in reverse proportional to thickness.…”

Section: Stretchable and Conformal Sensors For Cyber Biophysical Intementioning

confidence: 99%

Cyber–Physiochemical Interfaces

et al. 2020

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Living things rely on various physical, chemical, and biological interfaces, e.g., somatosensation, olfactory/gustatory perception, and nervous system response. They help organisms to perceive the world, adapt to their surroundings, and maintain internal and external balance. Interfacial information exchanges are complicated but efficient, delicate but precise, and multimodal but unisonous, which has driven researchers to study the science of such interfaces and develop techniques with potential applications in health monitoring, smart robotics, future wearable devices, and cyber physical/human systems. To understand better the issues in these interfaces, a cyber–physiochemical interface (CPI) that is capable of extracting biophysical and biochemical signals, and closely relating them to electronic, communication, and computing technology, to provide the core for aforementioned applications, is proposed. The scientific and technical progress in CPI is summarized, and the challenges to and strategies for building stable interfaces, including materials, sensor development, system integration, and data processing techniques are discussed. It is hoped that this will result in an unprecedented multi‐disciplinary network of scientific collaboration in CPI to explore much uncharted territory for progress, providing technical inspiration—to the development of the next‐generation personal healthcare technology, smart sports‐technology, adaptive prosthetics and augmentation of human capability, etc.

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Section: Stretchable and Conformal Sensors For Cyber Biophysical Intementioning

confidence: 99%

Cyber–Physiochemical Interfaces

et al. 2020

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“…Among freestanding devices, optically responsive materials are especially appealing because of their fast response time, the ubiquity of light sources that are usable for stimulation, the wide variety of available form factors, and the ability to tune the contributions of different photoresponses. The nature of these responses can be to generate heat (photothermal), [ 60,80 ] generate a capacitive current (photocapacitive), [ 60 ] induce redox reactions (photofaradaic), [ 44 ] or to re‐emit photons, which can proceed through fluorescence [ 22 ] or upconversion [ 81 ] mechanisms.…”

Section: Modulationmentioning

confidence: 99%

“…SiNWs are capable of eliciting Ca 2+ responses through a primary photofaradaic stimulation, [ 44 ] but other related materials may also act through photocapacitive [ 60 ] and photothermal [ 99 ] mechanisms. They have a low but noticeable capacitive response, a strong faradaic response, and a low but nonzero photothermal response.…”

Section: Modulationmentioning

confidence: 99%

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Biological Interfaces, Modulation, and Sensing with Inorganic Nano‐Bioelectronic Materials

Schaumann

Tian

2020

Small Methods

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systems have already yielded impressive results, such as a bionic hand with sensory feedback, [11] and a closed-loop optogenetic system that can modulate bladder function in rats. [12] These developments provide us with a helpful template for the future of nano-bioelectronics. In the coming years, we expect to see a proliferation of integrated devices and closed-loop systems that incorporate nanoelectronics in biological contexts.Nanoelectronics present us with a number of features that make them particularly desirable in biological research. Nanomaterials can possess unique optical, [13] electronic, [14,15] and magnetic [16,17] properties that only become evident at sufficiently small length scales. Moreover, nanoelectronics provide the opportunity to probe the coupling of electric phenomena and physiology from the scale of tissues and organs down to the scale of individual cells and organelles (Figure 1). [18][19][20][21] The ability of these materials to target such small structures opens the door to inquiries into the pathways for electrical transduction in biology at the scale of the pertinent molecules, and to leverage those to access therapeutic targets that would otherwise be unavailable.We draw a contrast here between inorganic nanobioelectronics, which are the focus of this Progress Report, and organic nano-bioelectronics, which are also a subject of intense research. Inorganic devices in this context are typically made from semiconductor or metal materials, while organic ones are primarily carbon-based and may be derived from biological sources. Organic devices have shown great promise as bioelectronics, and we refer the reader to a small selection of the numerous excellent articles regarding nanodiamonds, [22][23][24][25][26] carbon nanotubes, [27][28][29] and graphene-based materials [15,30,31] as well as conjugated polymers [32] and biologically-derived nanomaterials. [33,34] In broad terms, the advantages of inorganic nanomaterials are that they can adopt a wide array of precisely tunable architectures and functionalities, which can be achieved through numerous techniques during synthesis. [15,[35][36][37][38] Their disadvantages include potentially high costs of manufacture, particularly with respect to noble metal precursors, [36,39] and the possibility for accumulation without degradation in cells. [40,41] Organic nanomaterials tend to have good biocompatibility when functionalized appropriately. [23,26,32,42] They also integrate well with other bioelectronic tools, either as extensions to scaffolds [32] or as the scaffolds themselves, [33] and they can minimize negative cellular responses to mechanical mismatches between the cytoskeleton and the device. [32,33] Compared to inorganic The last several years have seen a large and increasing interest in scientific developments that combine methods and materials from nanotechnology with questions and applications in bioelectronics. This follows with a number of broader trends: the rapid increase in functionality for materials at the nanoscale; a gro...

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“…However, direct IR stimulation does not provide cell specificity, spatial stimulation precision, or subcellular resolution, and suffers from a narrow energy density threshold for stimulation vs. damage to the tissue (9,10). An emerging alternative that can provide nongenetic, instantaneous, and spatial control is photothermal stimulation using Au-and Sibased nanomaterials (11)(12)(13)(14). Although this approach can provide light-based control similar to optogenetics (with subcellular precision), it has limitations, including the need for relatively high laser power, low photothermal conversion efficiency, low absorption cross-section, and limited long-term stability when a stable interface is needed (15,16).…”

mentioning

confidence: 99%

Remote nongenetic optical modulation of neuronal activity using fuzzy graphene

Rastogi

Garg

Scopelliti

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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The ability to modulate cellular electrophysiology is fundamental to the investigation of development, function, and disease. Currently, there is a need for remote, nongenetic, light-induced control of cellular activity in two-dimensional (2D) and three-dimensional (3D) platforms. Here, we report a breakthrough hybrid nanomaterial for remote, nongenetic, photothermal stimulation of 2D and 3D neural cellular systems. We combine one-dimensional (1D) nanowires (NWs) and 2D graphene flakes grown out-of-plane for highly controlled photothermal stimulation at subcellular precision without the need for genetic modification, with laser energies lower than a hundred nanojoules, one to two orders of magnitude lower than Au-, C-, and Si-based nanomaterials. Photothermal stimulation using NW-templated 3D fuzzy graphene (NT-3DFG) is flexible due to its broadband absorption and does not generate cellular stress. Therefore, it serves as a powerful toolset for studies of cell signaling within and between tissues and can enable therapeutic interventions.

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Texturing Silicon Nanowires for Highly Localized Optical Modulation of Cellular Dynamics

Cited by 53 publications

References 39 publications

Cyber–Physiochemical Interfaces

Cyber–Physiochemical Interfaces

Biological Interfaces, Modulation, and Sensing with Inorganic Nano‐Bioelectronic Materials

Remote nongenetic optical modulation of neuronal activity using fuzzy graphene

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