Textured Surface Breast Implants in the Prevention of Capsular Contracture among Breast Augmentation Patients: A Meta-Analysis of Randomized Controlled Trials

Barnsley, G Philip; Sigurdson, Leif; Barnsley, Shannon E

doi:10.1097/01.prs.0000218184.47372.d5

Cited by 307 publications

(188 citation statements)

References 36 publications

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“…The search for prevention and less morbid/invasive treatment for this phenomenon has been the subject of several studies; however, so far, no study has clearly demonstrated their effectiveness [3][4][5][6][7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

“…In this type of surgery, the capsular contracture is the main complication 3,4 observed in up to 50% 4,5 of patients in two years following the surgery [3][4][5][6][7] . The fibrous tissue formed around the prosthesis promotes its compression and can cause esthetic involvement (distortion, asymmetry and hardening of the breast) and painful symptoms [4][5][6][7][8][9] , making it sometimes frustrating for both patients and surgeons 5,6 .…”

Section: Introductionmentioning

confidence: 99%

“…The fibrous tissue formed around the prosthesis promotes its compression and can cause esthetic involvement (distortion, asymmetry and hardening of the breast) and painful symptoms [4][5][6][7][8][9] , making it sometimes frustrating for both patients and surgeons 5,6 .…”

Section: Introductionmentioning

confidence: 99%

“…The standard treatment is capsulectomy with implant replacement, which would require additional surgery, with all its risks and inherent burdens 3,[6][7][8][9][10] . The search for prevention and less morbid/invasive treatment for this phenomenon has been the subject of several studies; however, so far, no study has clearly demonstrated their effectiveness [3][4][5][6][7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of zafirlukast on capsular contracture around silicone implants in rats

et al. 2012

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PURPOSE:To evaluate the effect of zafirlukast on capsular contracture around silicone implants by measuring the pressure within the implant, using a rat experimental model. METHODS: Forty adult female Wistar rats were used. Each one received two silicone implants, one with smooth-surface and the other with textured-surface. They were randomly divided into four groups (n=10). The rats of control group I were sacrificed after the implants. The remaining animals were subjected to a daily regimen of intra-peritoneal injection for a period of 90 days and they were distributed as follows: control group II received 0.9% physiological saline solution; experimental group I received zafirlukast 1.25 mg/kg; and experimental group II received zafirlukast 5 mg/kg. The measurement of intra-implant pressure of control group I was determined on the surgery day and in other groups on the ninetieth day, after being sacrificed. RESULTS: In the evaluation of textured implants there was an increase of internal pressure in the control group II, and there was no increase in the experimental groups. Compared to the controls there were not significant differences in smooth implants. CONCLUSION: Zafirlukast reduced the risk of developing capsular contracture around silicone implants with textured surface. Key words: Breast Implants. Implant Capsular Contracture. Leukotriene Antagonists. Rats. RESUMO OBJETIVO: Avaliar o efeito do zafirlukast na contratura capsular ao redor de implantes de silicone, através da aferição da pressão intra-implante, utilizando-se um modelo experimental de ratos. MÉTODOS: Quarenta ratos fêmeas Wistar foram utilizados. Cada um recebeu dois implantes de silicone, sendo um com superfície lisa e outro texturizada. Foram divididos aleatoriamente em quatro grupos (n=10). Os ratos do grupo controle I foram sacrificados após o implante. O restante dos animais foi submetido a um regime diário de injeção intraperitoneal por um período de 90 dias e foram distribuídos: grupo controle II recebeu solução salina fisiológica 0,9%, grupo experimental I recebeu zafirlukast 1,25 mg/kg, e grupo experimental II recebeu zafirlukast 5 mg/kg. O grupo controle II recebeu solução salina; grupo experimental I, 1,25 mg/kg/dia de zafirlukast; grupo experimental II, 5mg/kg/dia de zafirlukast. A aferição da pressão intra-implante do grupo controle I foi averiguada no dia do ato operatório, e nos outros grupos no nonagésimo dia, após serem sacrificados. RESULTADOS: Na avaliação dos implantes texturizados houve aumento da pressão interna no grupo controle II e, não se observou aumento nos grupos experimentais. Na comparação com os controles não foram observadas diferenças significativas nos implantes lisos. CONCLUSÃO: O Zafirlukast reduziu o risco de desenvolver contratura capsular em torno de implantes de silicone com superfície texturizada. Descritores: Implantes de Mama. Contratura Capsular em Implantes. Antagonistas de Leucotrienos. Ratos.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of zafirlukast on capsular contracture around silicone implants in rats

et al. 2012

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“…An implant with a textured surface has less contracture than that with a smooth surface [14]. Therefore, textured type implants are thought to be more biocompatible with surrounding tissues.…”

Section: Discussionmentioning

confidence: 99%

Repeated Hemorrhage after Repair of Orbital Floor Fracture with a Silicone Implant

Kakizaki¹,

Ichinose²,

Takahashi³

et al. 2011

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A 16-year-old girl was accidentally kicked in her right eye by her cheerleading teammate in an exercise. Upward gaze ability of her right eye was severely impaired and computed tomography (CT) showed a trapdoor fracture of the right orbital floor. After surgical exploration, a silicone implant was inserted. No bleeding was confirmed at this time. The next day, CT detected a hematoma on the right orbital floor. The hematoma was drained and meticulous cautery was used to control any potential bleeding. The same silicone implant was re-inserted. Irrespective of attempts to avoid hemorrhage, this occurred twice after the respective evacuations. During a fourth operation, we removed the silicone implant simultaneously with hematoma evacuation. No hematoma has occurred since, and the patient's ocular movement has dramatically improved to a normal binocular single vision field. When repeated hemorrhages occur after an orbital floor fracture repair with insertion of a silicone implant, removal of the implant is an effective strategy to resolve the hemorrhage.

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Different types of implants for reconstructive breast surgery

Rocco

Rispoli²,

Moja

et al. 2014

Cochrane Database of Systematic Reviews

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* The basis f or the assumed risk (e.g. the m edian control group risk across studies) is provided in f ootnotes. The corresponding risk (and its 95% conf idence interval) is based on the assum ed risk in the com parison group and the relative effect of the intervention (and its 95% CI). CI: conf idence interval; RR: risk ratio GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our conf idence in the estim ate of ef f ect. M oderate quality: Further research is likely to have an im portant im pact on our conf idence in the estim ate of ef f ect and m ay change the estim ate. Low quality: Further research is very likely to have an im portant im pact on our conf idence in the estim ate of ef f ect and is likely to change the estim ate. Very low quality: We are very uncertain about the estim ate. 1 We downgraded twice based on unclear risk of selection, perf orm ance and detection bias. 2 We downgraded once because the result was based on only one study with 20 participants.

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Textured Surface Breast Implants in the Prevention of Capsular Contracture among Breast Augmentation Patients: A Meta-Analysis of Randomized Controlled Trials

Abstract: The results of this meta-analysis demonstrate the superiority of textured over smooth breast implants in decreasing the rate of capsular contracture.

Cited by 307 publications

References 36 publications

Effect of zafirlukast on capsular contracture around silicone implants in rats

Effect of zafirlukast on capsular contracture around silicone implants in rats

Repeated Hemorrhage after Repair of Orbital Floor Fracture with a Silicone Implant

Different types of implants for reconstructive breast surgery

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