Textile industrial effluent induces mutagenicity and oxidative DNA damage and exploits oxidative stress biomarkers in rats

Akhtar, Muhammad Furqan; Ashraf, Muhammad; Anjum, Aftab Ahmad; Javeed, Aqeel; Sharif, Ali; Saleem, Ammara; Akhtar, Bushra

doi:10.1016/j.etap.2015.11.022

Cited by 53 publications

(38 citation statements)

References 39 publications

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“…Hepatotoxicity can occur directly or indirectly due to ROS (Akhtar et al, 2016b). It is usually associated with a decrease in activity of endogenous anti-oxidant enzymes (Sharif et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective potential and chemical characterization of Artocarpus lakoocha fruit extract

Saleem

Asif

Akhtar

et al. 2018

Bangladesh J Pharmacol

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Artocarpus lakoocha fruits are widely consumed as food. The study was aimed at evaluating its hepatoprotective activity and chemical constituents. The extract was analysed by HPLC for the presence of flavonoids and phenolic compounds. Hepatoprotective potential was determined in mice following 8 days of extract or silymarin (standard therapy) administration. Hepatotoxicity was induced by administration of paracetamol (500 mg/kg). The blood and liver of treated and untreated mice were collected 24 hours post-paracetamol intoxication. HPLC analysis confirmed the presence of chromatotropic acid, quercetin, gallic acid, vanillic acid, cinnamic acid, ferulic acid and kaempferol. Acute toxicity study showed no observed effect at more than 2,000 mg/kg. The fruit extract prevented the rise in liver function tests and paracetamol related histopathological alterations. The hepatoprotective activity of extract was dose-dependent. This study confirms the preventive effect of methanolic extract of monkey jack fruits against paracetamol-induced liver toxicity.Video Clip of Methodology:7 min 25 sec: <a href="https://www.youtube.com/v/oyuEIJc8pqU">Full Screen</a> <a href="https://www.youtube.com/watch?v=oyuEIJc8pqU">Alternate</a>

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective potential and chemical characterization of Artocarpus lakoocha fruit extract

Saleem

Asif

Akhtar

et al. 2018

Bangladesh J Pharmacol

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“…Mutagenic Index (MI) was calculated using the formula in which number of revertant colonies of the test extracts were divided by the number of revertant colonies of the negative control. Sample was considered mutagenic if the MI of the tested concentration was greater than 2 (Akhtar et al, 2016[2]). …”

Section: Methodsmentioning

confidence: 99%

Genotoxic and cytotoxic potential of whole plant extracts of Kalanchoe laciniata by Ames and MTT assay

Sharif

Akhtar

et al. 2017

EXCLI Journal; 16:Doc593; ISSN 1611-2156

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“…Top layer of agar was prepared by mixing this melting point agarose with trace amounts of histidine and biotin. This top agar was poured on glucose minimal agar plates and incubated at 37 °C for 24 hrs (Akhtar et al, 2016[4]). Revertant colonies were counted manually.…”

Section: Methodsmentioning

confidence: 99%

Genotoxic and cytotoxic action potential of Terminalia citrina, a medicinal plant of ethnopharmacological significance

Akhtar

Saleem²,

Sharif

et al. 2016

EXCLI Journal; 15:Doc589; ISSN 1611-2156

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Textile industrial effluent induces mutagenicity and oxidative DNA damage and exploits oxidative stress biomarkers in rats

Cited by 53 publications

References 39 publications

Hepatoprotective potential and chemical characterization of Artocarpus lakoocha fruit extract

Hepatoprotective potential and chemical characterization of Artocarpus lakoocha fruit extract

Genotoxic and cytotoxic potential of whole plant extracts of Kalanchoe laciniata by Ames and MTT assay

Genotoxic and cytotoxic action potential of Terminalia citrina, a medicinal plant of ethnopharmacological significance

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