Teucrium polium improves endothelial dysfunction by regulating eNOS and VCAM-1 genes expression and vasoreactivity in diabetic rat aorta

Khodadadi, Sakineh; Zabihi, Narges Amel; Niazmand, Saeed; Abbasnezhad, Abbasali; Mahmoudabady, Maryam; Rezaee, Seyed Abdolrahim

doi:10.1016/j.biopha.2018.04.158

Cited by 15 publications

(12 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genes involved in vasodilation included angiotensin 2 receptor type 2 ( AT2 ) [40,41,42], endothelial nitric oxide synthase ( eNOS ) [43], adenosine A2A receptor ( ADORA2A ) [44,45], VEGF-A [43], prostaglandin E receptor 2 ( PGE2 ) [46], and prostaglandin I2 receptor ( PGI2 ) [47]. The expression levels of AT2 (Figure 7e), eNOS (Figure 7f), VEGF-A (Figure 7h), and PGI2 (Figure 7i) exhibited interaction effects ( p < 0.05, two-way ANOVA) and a main effect for both time and treatment (TTS vs. PTS, p < 0.05, two-way ANOVA).…”

Section: Resultsmentioning

confidence: 99%

Acoustic Trauma Modulates Cochlear Blood Flow and Vasoactive Factors in a Rodent Model of Noise-Induced Hearing Loss

Shin

Lyu

Jeong

et al. 2019

IJMS

View full text Add to dashboard Cite

Noise exposure affects the organ of Corti and the lateral wall of the cochlea, including the stria vascularis and spiral ligament. Although the inner ear vasculature and spiral ligament fibrocytes in the lateral wall consist of a significant proportion of cells in the cochlea, relatively little is known regarding their functional significance. In this study, 6-week-old male C57BL/6 mice were exposed to noise trauma to induce transient hearing threshold shift (TTS) or permanent hearing threshold shift (PTS). Compared to mice with TTS, mice with PTS exhibited lower cochlear blood flow and lower vessel diameter in the stria vascularis, accompanied by reduced expression levels of genes involved in vasodilation and increased expression levels of genes related to vasoconstriction. Ultrastructural analyses by transmission electron microscopy revealed that the stria vascularis and spiral ligament fibrocytes were more damaged by PTS than by TTS. Moreover, mice with PTS expressed significantly higher levels of proinflammatory cytokines in the cochlea (e.g., IL-1β, IL-6, and TNF-α). Overall, our findings suggest that cochlear microcirculation and lateral wall pathologies are differentially modulated by the severity of acoustic trauma and are associated with changes in vasoactive factors and inflammatory responses in the cochlea.

show abstract

Section: Resultsmentioning

confidence: 99%

Acoustic Trauma Modulates Cochlear Blood Flow and Vasoactive Factors in a Rodent Model of Noise-Induced Hearing Loss

Shin

Lyu

Jeong

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…Endothelial dysfunction is the major cause of vascular complications in diabetes. Under conditions of hyperglycemia and/or hyperlipidemia, increased production of RONS is observed, with concomitant reduced capacity of antioxidant systems ( Khodadadi et al, 2018 ; Zhao and Singh, 2018 ; Shye et al, 2020 ). Endothelial cells produce many substances that are responsible for maintaining vascular homeostasis and thus influence the whole body condition.…”

Section: Discussionmentioning

confidence: 99%

Changes in Oxidative and Nitrosative Stress Indicators and Vascular Endothelial Growth Factor After Maximum-Intensity Exercise Assessing Aerobic Capacity in Males With Type 1 Diabetes Mellitus

et al. 2021

View full text Add to dashboard Cite

In type 1 diabetes mellitus (T1DM), chronic hyperglycemia causes reactive oxygen and nitrogen species production. Exercise alters the oxidant-antioxidant balance. We evaluated the aerobic capacity and oxidant-antioxidant balance changes after maximum-intensity exercise in T1DM patients. The study involved 30 T1DM participants and 23 controls. The patients’ average age was 23.4 ± 5.1 years, with a body mass index of 24.3 ± 3.1 kg m–2 and with satisfactory glycemic control. Among the controls, the respective values equaled 24.7 ± 2.9 years and 22.9 ± 2.1 kg m–2. Aerobic capacity was assessed with a treadmill test. Peak minute oxygen uptake was significantly lower in T1DM compared with the controls (44.7 ± 5.7 vs. 56.0 ± 7.3 mL kg–1 min–1). The total oxidant capacity measured by total oxidative status/total oxidative capacity (TOS/TOC) equaled 321.5 ± 151 μmol L–1 before and 380.1 ± 153 μmol L–1 after exercise in T1DM, and 164.1 ± 75 and 216.6 ± 75 μmol L–1 in the controls (p < 0.05 for all comparisons). A significant difference in the ratio of total antioxidant status/total antioxidant capacity (TAS/TAC) between the groups after the treadmill test was observed (p < 0.05). Nitrosative stress indicators where significantly higher in the T1DM group both before and after the exercise. In conclusion, diabetic patients demonstrated a lower aerobic capacity. The TOS/TOC and nitrosative stress indicators were significantly higher in T1DM before and after the test.

show abstract

“…Previous studies have shown that VCAM-1 expression increases in the aortic tissue of diabetic rats. VCAM-1 may recruit monocytes and plays an essential role in the onset and development of inflammation [28] by increasing leukocyte recruitment to the microvascular wall. Phytochemical studies regarding vascular diseases have shown that many phenolic compounds with pharmacological potential are major metabolites in E. grandiflorus leaf extracts [10].…”

Section: Discussionmentioning

confidence: 99%

Microvascular Effects of Echinodorus grandiflorus on Cardiovascular Disorders

et al. 2020

View full text Add to dashboard Cite

Echinodorus grandiflorus is a semiaquatic plant native to Brazil and belongs to the Alismataceae family. Infusion preparations of the leaves of this plant are often used due to its diuretic, blood pressure lowering, and anti-inflammatory properties. Our aim was to investigate the effects of chronic treatment with the crude hydroalcoholic extract of E. grandiflorus on central and peripheral microvascular changes induced in a model of hypertension and diabetes. The hemodynamic and microvascular effects of E. grandiflorus extract (50, 100, or 200 mg/kg/day for 28 days) or the isolated major diterpene from E. grandiflorus (3 to 10 mg/kg i. v.) were evaluated in spontaneously hypertensive rats using tail plethysmography and intravital fluorescence videomicroscopy, respectively, and were compared to vehicle-treated normotensive Wistar-Kyoto rats. We also investigated the protective effects of chronic treatment with E. grandiflorus (100 mg/kg/day) in brain capillary density and leukocyte-endothelium interactions on the brain vessels of DM-spontaneously (DM: diabetes mellitus) hypertensive rats. Chronically treating spontaneously hypertensive rats with increasing doses of crude hydroalcoholic E. grandiflorus extract resulted in significant dose-dependent reductions in systolic blood pressure and an anti-inflammatory effect on the brain microcirculation of DM-spontaneously hypertensive rat animals. Using laser speckle contrast imaging, we observed that intravenous administration of the major isolated clerodane diterpene metabolite (1 – 10 mg/kg) increased microvascular blood flow by 25% in spontaneously hypertensive rat skeletal muscle. The results of this study show that E. grandiflorus extracts can be useful in the prevention and reduction of microcirculatory damage in arterial hypertension and other diseases that involve microvascular dysfunction.

show abstract

Teucrium polium improves endothelial dysfunction by regulating eNOS and VCAM-1 genes expression and vasoreactivity in diabetic rat aorta

Cited by 15 publications

References 48 publications

Acoustic Trauma Modulates Cochlear Blood Flow and Vasoactive Factors in a Rodent Model of Noise-Induced Hearing Loss

Acoustic Trauma Modulates Cochlear Blood Flow and Vasoactive Factors in a Rodent Model of Noise-Induced Hearing Loss

Changes in Oxidative and Nitrosative Stress Indicators and Vascular Endothelial Growth Factor After Maximum-Intensity Exercise Assessing Aerobic Capacity in Males With Type 1 Diabetes Mellitus

Microvascular Effects of Echinodorus grandiflorus on Cardiovascular Disorders

Contact Info

Product

Resources

About