Teucrium polium Extract Enhances the Anti-Angiogenesis Effect of Tranilast on Human Umbilical Vein Endothelial Cells

Sheikhbahaei, Fatemeh; Khazaei, Mozafar; Nematollahi-Mahani, Seyed Noureddin

doi:10.15171/apb.2018.016

Cited by 14 publications

(6 citation statements)

References 34 publications

(31 reference statements)

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“…They could successfully report a higher cell death rate in the combination therapy using anticancer drugs, including vincristine, doxorubicin, and vinblastine. Shikhbahaei et al (22), demonstrated that a combination of PE fraction of T. polium with tranilast, an anti-angiogenesis substance, decreased angiogenesis and its related genes significantly. Cell arrest at the S phase was postulated as the main molecular mechanism for the cytotoxic potential of T. polium.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Crude Extract and Fractions of Teucrium polium L. on the Brain, Liver, and Kidney of Male Rats

Nematollahi-Mahani

Ganjalikhan-Hakemi

Abdi

2021

Jundishapur J Nat Pharm Prod

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Background: Teucrium polium (TP) is a medicinal plant with a long history of consumption as a folk remedy for curing many diseases, including diabetes, common cold, obesity, anxiety, etc. Objectives: The present study aimed at investigating the effects of TP crude extracts (TPCE), as well as its diethyl ether (DE) and petroleum ether (PE) fractions, on the brain, kidney, and liver tissue of male rats in the subchronic phase. Methods: In the study, 45 adult male Wistar rats were randomly assigned to five groups as the PBS (receiving phosphate buffer saline), vehicle (receiving dimethyl sulfoxide), as well as CE, PE, and DE receiving 3 mg/kg (100 µL) TPCE, PE, and DE, respectively, for six weeks. Histopathological examinations by hematoxylin and eosin staining investigated morphological changes in all specimens. Also, the brain samples were stained by the immunohistochemistry (IHC) technique with Ki-67, CD31, p53, Nestin, and GFAP markers. Results: The findings showed that the prolonged consumption of TP caused the formation of histological lesions as apoptosis, degeneration, cytoplasmic vacuolization of neurons, and foamy cells in the brain. The liver, displayed cytoplasmic vacuolization, apoptosis, degeneration, and dilated sinusoids. Moreover, TP led to atrophy, vacuolization, and necrosis in renal cells. IHC studies evidenced an increase in the expression of P53, whereas the expression of Ki67 and CD31 decreased. It should be noted that TP crude extract and fractions were toxic; however, the PE fraction was more cytotoxic than others. Conclusions: The study findings indicated that long-term administration of a sublethal dose of TP impairs cellular integrity in vital orangs, including the liver, brain, and kidney, through triggering the cell death mechanisms.

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Section: Discussionmentioning

confidence: 99%

The Effect of Crude Extract and Fractions of Teucrium polium L. on the Brain, Liver, and Kidney of Male Rats

Nematollahi-Mahani

Ganjalikhan-Hakemi

Abdi

2021

Jundishapur J Nat Pharm Prod

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“…No lesions (pathological abnormalities) were observed in these organs.Our findings are in agreement with previous studies on the biochemical and haematological responses of Wistar rats to Pterocarpus santalinus. 26,27 Additionally, studies have shown that fresh and dried leaves of Pterocarpu ssantalinus contain alkaloids, flavonoids, glycosides, saponins, tannins, phenolics and triterpenoids. 28,29 The antioxidant activity of some of the secondary metabolites such as saponins, tannins, phenols and triterpenoids present in the plant may be responsible for their ability to reduce necrotic tissue in the organs (brain and heart) investigated.…”

Section: Effect Of Pterocarpus Santalinus Ethanol Leaf Extract On The...mentioning

confidence: 99%

Effect of Pterocarpus santalinus Ethanol Leaf Extract on Haematological, Histopathological and Lipid Profile Indices in Wistar Rats

2024

TJNPR

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Pterocarpus santalinus commonly calledred Sandalwoodis a small to medium-sized tree belonging to the Fabaceae family. It is widely distributed in many parts of the world, especially in India, Sri Lanka, Saudi Arabia, Taiwan and China. 8 The leaves are trifoliate and alternate, and are approximately 3-9 cm long. The flowers are in long clusters, and the fruit is a 6-9 cm long pod with one or two seeds. Pterocarpus santalinus is a flavonoid-and phenolic-rich medicinal plant that has many medicinal uses. 9,10 In herbal medicine, Pterocarpus santalinus is used as an antibacterial, antibiotic and diaphoretic agent. 11,12 The aim of this study was to evaluate the sub-acute toxicity of ethanol leaf extract of Pterostilbenein Wistar rats. Materials and Method Plant collectionFresh Pterocarpus santalinus leaves were collected in December, 2021 from Karu village and neighboring communities in Nasarawa State, Nigeria. The plant material was identified and authenticated in the

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“…The cell cytotoxicity was evaluated by MTT method according to the published method. 18 Briefly, 5 Â 10 3 cancer cells per well were seeded in 96-well plates and incubated for 24 h.…”

Section: Cell Proliferation Analysis and Immunization Of Cervical Carcinoma-bearing Micementioning

confidence: 99%

Amino acid sequence identification of goji berry cyclic peptides and anticervical carcinoma activity detection

Guo

et al. 2021

Journal of Peptide Science

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The goji berry is widely used as tonics; however, the antihuman cervical carcinoma effect and underlying mechanism of goji berry peptide remain to be elucidated. The cyclic peptides are appealing targets in antitumor agent development, and in current study, three novel goji berry cyclic peptides (GCPs) were isolated and amino acid sequence identified. Among them, GCP-1 (Cycle-(Trp-Glu-His-Thr)) inhibited proliferation and induced human cervical cancer (HeLa) cells apoptosis and blocked the HeLa cells in G0/G1 phase significantly. Furthermore, the GCP-1 also inhibited the cervical carcinoma growth in vivo. Moreover, GCP-1 suppressed the cyclin expression and activated the caspase cascade and poly(ADP-ribose) polymerase. Of note, GCP-1 may be a promising novel inhibitor of human cervical cancer. Highlights• Three novel goji berry cyclic peptides (GCPs) were amino acid sequences identified, and antiproliferative activity was evaluated in three cervical cancer cell lines (C33A, SiHa, and HeLa) in vitro.• GCP-1 showed the most antiproliferative activity against HeLa cells with an IC 50 of 80.2 ± 7.93 μM (48 h).• GCP-1 induced the HeLa cell apoptosis and blocked the HeLa cells in G0/G1 phase.• GCP-1 suppressed the cyclin expression accompanied with the activation of the caspase cascade.

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Teucrium polium Extract Enhances the Anti-Angiogenesis Effect of Tranilast on Human Umbilical Vein Endothelial Cells

Cited by 14 publications

References 34 publications

The Effect of Crude Extract and Fractions of Teucrium polium L. on the Brain, Liver, and Kidney of Male Rats

The Effect of Crude Extract and Fractions of Teucrium polium L. on the Brain, Liver, and Kidney of Male Rats

Effect of Pterocarpus santalinus Ethanol Leaf Extract on Haematological, Histopathological and Lipid Profile Indices in Wistar Rats

Amino acid sequence identification of goji berry cyclic peptides and anticervical carcinoma activity detection

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