Tetrazolium Compounds: Synthesis and Applications in Medicine

Abstract

Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide range of applications in many fields of medicine, agriculture, material science, etc. Based on our research works on azoles and other references in recent years, this review covers reported work on the synthesis and biological activities of tetrazole derivatives.

DFT, Hirshfeld surfaces, spectral and in vivo cytotoxic studies of 7a-Aza-B-homostigmast-5-eno [7a,7-d] tetrazole

“…The applicability of tetrazoles derivatives can be estimated from the fact that dimethyl thiazolyl diphenyl tetrazolium salt is commonly employed as standard, in MTT assay to quantify the respiratory activity of live cells in cell culture, although it kills cells in the process [8][9]. Nowadays, tetrazolium compounds are extensively employed in the synthesis of drugs, explosives and other functional materials having applications in medicine, agriculture, material science etc [10]. The heat of formation for 49 tetrazole derivatives was computed using density functional theory [11].…”

In situ green synthesis of Cu‐Ni bimetallic nanoparticles supported on reduced graphene oxide as an effective and recyclable catalyst for the synthesis of N‐benzyl‐N‐aryl‐5‐amino‐1H‐tetrazoles

“…Tetrazoles are a valuable class of nitrogen rich heterocycles which increased attentions to these structures come from their widespread medicinal, biological and industrial applications . For some exceptional properties of these compounds in coordination chemistry as ligands, in pharmaceutical as isosteres and lipophilic spacers, and in material science as rocket propellants, explosives, and gas generators, they occupied a special position in intense research activities . Further, tetrazole derivatives can be extensively used as synthons for the preparation of N ‐containing compounds in organic synthetic chemistry and in organocatalysis .…”

Ultrafast Dynamics of a Fluorescent Tetrazolium Compound in Solution

“…They are the basis of standardized assays in diverse research areas comprising agriculture, [1,2] cell biology, [3,4] cancerr esearch, [5,6] and furtherf ields of medicine, [7,8] are employed in versatile ways in organic chemistry, [9,10] may act as cations in ionic liquids, [11,12] or can be used in dosimetry to quantify the amount of ultraviolet light. They are the basis of standardized assays in diverse research areas comprising agriculture, [1,2] cell biology, [3,4] cancerr esearch, [5,6] and furtherf ields of medicine, [7,8] are employed in versatile ways in organic chemistry, [9,10] may act as cations in ionic liquids, [11,12] or can be used in dosimetry to quantify the amount of ultraviolet light.…”