Tetrastigma hemsleyanum leaves extract against acrylamide-induced toxicity in HepG2 cells and Caenorhabditis elegans

Chu, Qiang; Chen, Wen; Jia, Ruoyi; Xiang, Yu‐Tao; Li, Yonglu; Liu, Yangyang; Jiang, Yong; Zheng, Xiaodong

doi:10.1016/j.jhazmat.2020.122364

Cited by 41 publications

(26 citation statements)

References 43 publications

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“…Similarly, resveratrol attenuated iron-induced toxicity in C. elegans [ 52 ]. A traditional Chinese medicine, Tetrastigma hemsleyanum , protected C. elegans from the toxicity induced by acrylamide through reducing the level of ROS [ 53 ]. Hence, we suspected that EBL, possessing strong antioxidant ability, could protect the organ from oxidative damage, which would be a promising perspective.…”

Section: Discussionmentioning

confidence: 99%

Polyphenols from Blumea laciniata Extended the Lifespan and Enhanced Resistance to Stress in Caenorhabditis elegans via the Insulin Signaling Pathway

et al. 2021

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Blumea laciniata is widely used as a folk medicine in Asia, but relevant literature on it is rarely reported. We confirmed that polyphenol extract (containing chlorogenic acid, rutin, and luteolin-4-O-glucoside) from B. laciniata (EBL) showed strong antioxidant ability in vitro. Hence, in this work, we applied Caenorhabditis elegans to further investigate the antioxidant and anti-ageing abilities of EBL in vivo. The results showed that EBL enhanced the survival of C. elegans under thermal stress by 12.62% and sharply reduced the reactive oxygen species level as well as the content of malonaldehyde. Moreover, EBL increased the activities of antioxidant enzymes such as catalase and superoxide dismutase. Additionally, EBL promoted DAF-16, a transcription factor, into the nucleus. Besides, EBL extended the lifespan of C. elegans by 17.39%, showing an anti-ageing effect. Different mutants indicated that the insulin/IGF-1 signaling pathway participated in the antioxidant and anti-ageing effect of EBL on C. elegans.

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Section: Discussionmentioning

confidence: 99%

Polyphenols from Blumea laciniata Extended the Lifespan and Enhanced Resistance to Stress in Caenorhabditis elegans via the Insulin Signaling Pathway

et al. 2021

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“…In recent years, T. hemsleyanum has been widely used in the prevention and treatment of lung cancer, stomach cancer, colorectal cancer, liver cancer, breast cancer, cervical cancer, thyroid cancer, esophageal cancer, pancreatic cancer, lymphoid cancer and brain tumor ( Chu et al, 2019 , 2020 ). It has the characteristics of multi-target, multi-pathway, synergistic effect, non-toxicity, which is valuable for the development of new drugs for the treatment of tumor.…”

Section: Pharmacologymentioning

confidence: 99%

A comprehensive review on traditional uses, chemical compositions, pharmacology properties and toxicology of Tetrastigma hemsleyanum

Juan

et al. 2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance Tetrastigma hemsleyanum Diels et Gilg ( T.hemsleyanum ), a rare herbal plant distributed in subtropical areas of mainland China, has become a focus of scientiﬁc attention in recent years because of its high traditional value, including uses for treatment of children with fever, pneumonia, asthma, rheumatism, hepatitis, menstrual disorders, scrofula, and pharynx pain. Aim This systematic review aims to provide an insightful understanding of traditional uses, chemical composition, pharmacological effect and clinical application of T. hemsleyanum , and lay a foundation for the further study and for the utilization of T. hemsleyanum resource. Materials and methods A domestic and overseas literature search in known databases was conducted for published articles using the relevant keywords. Results One hundred and forty-two chemical constituents identified from T. hemsleyanum have been reported, including flavonoids, phenolic acids, polysaccharide, organic acids, fatty acids, terpenoids, steroids, amino acid and others. Among these components, flavonoids and polysaccharides were the representative active ingredients of T. hemsleyanum , which have been widely investigated. Modern pharmacological studies have shown that these components exhibited various pharmacological activities, such as anti-inflammatory, antioxidant, antivirus, antitumor, antipyretic, anti-hepatic injury, immunomodulatory, antibacterial etc. Moreover, different toxicological studies indicated that the clinical dosage of T. hemsleyanum was safe and reliable. Conclusions Modern pharmacological studies have well supported and clarified some traditional uses, and T. hemsleyanum has a good prospect for the development of new drugs due to these outstanding properties. However, the present findings did not provide an in-depth evaluation of bioactivity of the extracts, the composition of its active extracts was not clear. Moreover, they were insufficient to satisfactorily explain some mechanisms of action. Data regarding many aspects of T. hemsleyanum , such as links between the traditional uses and bioactivities, pharmacokinetics, quality control standard and the clinical value of active compositions is still limited which need more attention.

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“…Chen et al (2019) employ a method of metabolomics combined with HPLC/MS and find that TDG's polysaccharide interferes with the conversion of F6P to FBP and inhibits the E. coli's proliferation. Chu et al (2020) explore the protective mechanism of TDG leaves extract against ACR induced toxicities in HepG2 cells and Caenorhabditis elegans (C. elegans). They find that TDG leaves attenuated ACR induces HepG2 cytotoxicity and prevents HepG2 cells from oxidative stress induced by ACR via regulating Akt/mTOR/FoxO1/MAPK signaling pathway.…”

Section: Other Activitiesmentioning

confidence: 99%

“…(2019) employ a method of metabolomics combined with HPLC/MS and find that TDG’s polysaccharide interferes with the conversion of F6P to FBP and inhibits the E. coli’s proliferation. Chu et al. (2020) explore the protective mechanism of TDG leaves extract against ACR induced toxicities in HepG2 cells and Caenorhabditis elegans ( C. elegans ).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

The Phytochemistry, Pharmacology, and Quality Control of Tetrastigma hemsleyanum Diels & Gilg in China: A Review

Zhu

Ying

et al. 2020

Front. Pharmacol.

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Tetrastigma hemsleyanum Diels & Gilg (TDG), the family member of Vitaceae, is a traditional herbal medicine in China. The root of TDG can be immediately used after cleaning the muddy soil, and can be dehydrated for dry use. TDG is able to be collected all year round, which is commonly used in the treatment of hepatitis, infantile high fever, snake bite, etc. Based on phytochemistry, the chemical components of TDG are divided into flavonoids, phenolic acids, terpenes, steroids, polysaccharide, and other compounds, showing many pharmacological effects which include anti-tumor, antioxidation, anti-inflammatory, antipyretic, analgesic, and immunomodulatory activity, as well as other activities. Currently, TDG involves some problems of the reduction of wild resources, the backward processing methods, and storage difficulties as well as the imperfection of detection methods. Therefore, this review summarizes the literature of the past 20 years, and the purpose of this review is to summarize the recent researches on the phytochemistry, pharmacology, quality control, and clinical application of TDG. The above discussions provide new insights for the future research on TDG.

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Tetrastigma hemsleyanum leaves extract against acrylamide-induced toxicity in HepG2 cells and Caenorhabditis elegans

Cited by 41 publications

References 43 publications

Polyphenols from Blumea laciniata Extended the Lifespan and Enhanced Resistance to Stress in Caenorhabditis elegans via the Insulin Signaling Pathway

Polyphenols from Blumea laciniata Extended the Lifespan and Enhanced Resistance to Stress in Caenorhabditis elegans via the Insulin Signaling Pathway

A comprehensive review on traditional uses, chemical compositions, pharmacology properties and toxicology of Tetrastigma hemsleyanum

The Phytochemistry, Pharmacology, and Quality Control of Tetrastigma hemsleyanum Diels & Gilg in China: A Review

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