Tetraphenylethene-based polymeric fluorescent probes for 2,4,6-trinitrophenol detection and specific lysosome labelling

Yao, Jinya; Zhuang, Zeyan; Yao, Hongming; Shi, Ruijie; Chang, Chen; Zhou, Jian; Zhao, Zujin

doi:10.1016/j.dyepig.2020.108588

Dyes and Pigments

2020

DOI: 10.1016/j.dyepig.2020.108588

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Tetraphenylethene-based polymeric fluorescent probes for 2,4,6-trinitrophenol detection and specific lysosome labelling

Jinya Yao

Zeyan Zhuang

Hongming Yao

et al.

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Cited by 11 publications

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“…20 Aggregation-induced emission (AIE) features a practical fluorescent strategy, which produces a strong luminous effect in the aggregated state, [21][22][23] thus perfectly solves the application limitation of the aggregation-caused quenching phenomenon. 24,25 Herein, we designed and developed a novel small molecule probe by combing cysteine with the typical tetraphenylethylen 26,27 group. Results showed that this unexpected combination turned out to be an excellent probe for lysosome-targeting.…”

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A novel lysosome‐localized fluorescent probe with aggregation‐induced emission without alkalinizing effect

et al. 2021

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Herein, a novel small molecule probe, tetraphenylethylene-cystein (TPE-Cys), was rationally designed and developed for the intracellular lysosome localization. The combination of tetraphenylethylene and cysteine serve as a novel strategy for lysosome-targeting, with significant aggregation-induced emission increases with the proportion of water by as high as 25-folds. Biofluorescence imaging experiments show that the probe TPE-Cys has a good colocalization effect with the commercially available lysotracker red, with a Pearson correlation coefficient of 0.91. In addition, we also demonstrate that TPE-Cys has good light stability. TPE-Cys, as a neutral compound, is free of alkalinizing effect when applied in lysosome localization. Moreover, molecular dynamics simulations and density function theories are employed to explore the detailed aggregation process and the mechanism of TPE-Cys aggregation in water solution. The mechanism of lysosome localization of probe TPE-Cys was explained by cellular endocytosis process and the formation of larger particle in the more acidic environment of lysosomes. This work not only demonstrates an efficient strategy for the construction of fluorescent probes for lysosome localization, but also indicates that they are promising as live cell imaging tools.

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A novel lysosome‐localized fluorescent probe with aggregation‐induced emission without alkalinizing effect

et al. 2021

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Design and synthesis of aggregation-caused quenching and aggregation-induced emission fluorescent nanoparticles for highly sensitive determination of metal ions

et al. 2022

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Cellular organelle-targeted smart AIEgens in tumor detection, imaging and therapeutics

Luo

et al. 2022

Coordination Chemistry Reviews

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Tetraphenylethene-based polymeric fluorescent probes for 2,4,6-trinitrophenol detection and specific lysosome labelling

Cited by 11 publications

References 57 publications

A novel lysosome‐localized fluorescent probe with aggregation‐induced emission without alkalinizing effect

A novel lysosome‐localized fluorescent probe with aggregation‐induced emission without alkalinizing effect

Design and synthesis of aggregation-caused quenching and aggregation-induced emission fluorescent nanoparticles for highly sensitive determination of metal ions

Cellular organelle-targeted smart AIEgens in tumor detection, imaging and therapeutics

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