Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos

Abstract

Two unprecedented tetranorlanostane triterpenoids, poricolides A (1) and B (2), and two new lanostane triterpenoids, 3β‐acetoxy‐24‐methyllanosta‐8,16,24(31)‐trien‐21‐oic acid (3) and 3β‐acetoxylanosta‐7,9(11),16,23‐tetraen‐21‐oic acid (4), were isolated from the epidermis of Poria cocos. The structures of 1–4 were determined via analysis of 1H‐, 13C‐, and 2D‐NMR, and HR‐ESI‐MS data, and the absolute configurations of 1 and 3 were established by single‐crystal X‐ray diffraction analysis. Compounds 1 and 2 were the first report of tetranorlanostane triterpenoid having a δ‐lactone ring at C(17). Compounds 3 and 4 were rare lanostane triterpenoids having a double bond between C(16) and C(17). Compounds 1–4 exhibited potent antiproliferative effects against A549, SMMC‐7721, MCF‐7, and SW480 cancer cell lines with IC50 values from 16.19±0.38 to 27.74±1.12 μM.

Pharmacological profiles and therapeutic applications of pachymic acid (Review)

“…PA was first discovered in the sclerotium of Poria cocos from which its name is derived (1). Since then, it has been observed as the active compound in several fungi, such as the sclerotium (15)(16)(17)(18)(19)(20)(21)(22)(23)(24) and epidermis (25) of Poria cocos and the…”

“…PA was first discovered in the sclerotium of Poria cocos from which its name is derived ( 1 ). Since then, it has been observed as the active compound in several fungi, such as the sclerotium ( 15-24 ) and epidermis ( 25 ) of Poria cocos and the fruiting bodies of Fomitopsis nigra ( 26 , 27 ) and Fomitopsis pinicola ( 28 , 29 ), which are used in traditional medicine. In addition to fungi, PA is extracted from Heterosmilax chinensis ( 30 ), a traditional Chinese medicine used for the treatment of cancer.…”