Tetrandrine and cancer – An overview on the molecular approach

Bhagya, N.; Chandrashekar, K. R.

doi:10.1016/j.biopha.2017.10.116

Cited by 83 publications

(20 citation statements)

References 144 publications

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“…In addition, it has been reported that natural products, including polyphenols, flavonoids and alkaloids, can reverse ABC transporter-related MDR [ 92 ]. For example, tetrandrine, a bisbenzylisoquinoline alkaloid isolated from Stephania tetrandra S. Moor, inhibits ABCC1 to reverse MDR in esophageal cancer [ 93 ].…”

Section: Drug That Mediate Abc Transporters: Abc Transporter Antagonimentioning

confidence: 99%

The impact of ATP-binding cassette transporters on metabolic diseases

Lü

2020

Nutr Metab (Lond)

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Currently, many people worldwide suffer from metabolic diseases caused by heredity and external factors, such as diet. One of the symptoms of metabolic diseases is abnormal lipid metabolism. ATP binding cassette (ABC) transporters are one of the largest transport protein superfamilies that exist in nearly all living organisms and are mainly located on lipid-processing cells. ABC transporters have been confirmed to be closely related to the pathogenesis of diseases such as metabolic diseases, cancer and Alzheimer’s disease based on their transport abilities. Notably, the capability to transport lipids makes ABC transporters critical in metabolic diseases. In addition, gene polymorphism in ABC transporters has been reported to be a risk factor for metabolic diseases, and it has been reported that relevant miRNAs have significant roles in regulating ABC transporters. In this review, we integrate recent studies to examine the roles of ABC transporters in metabolic diseases and aim to build a network with ABC transporters as the core, linking their transport abilities with metabolic and other diseases.

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Section: Drug That Mediate Abc Transporters: Abc Transporter Antagonimentioning

confidence: 99%

The impact of ATP-binding cassette transporters on metabolic diseases

Lü

2020

Nutr Metab (Lond)

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“…In modern Chinese Medicine, Tet is also used for the purpose of analgesic, anti-inflammation, treating tuberculosis, lowering blood pressure, antimyocardial ischemia, antiarrhythmia, antifibrosis, and anticancer etc. (Yin et al, 2007;Bhagya and Chandrashekar, 2018).…”

Section: Tetrandrinementioning

confidence: 99%

Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era?

Wang

Tan

et al. 2020

Front. Pharmacol.

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Liver fibrosis is a progressive liver damage condition that is worth studying widely. It is important to target and alleviate the disease at an early stage before turning into later cirrhosis or liver cancer. There are currently no direct medicines targeting the attenuation or reversal of liver fibrosis, and so there is an urgent need to look into this area. Traditional Chinese Medicine has a long history in using herbal medicines to treat liver diseases including fibrosis. It is time to integrate the ancient wisdom with modern science and technology to look for the best solution to the disease. In this review, the principal concept of the pathology of liver fibrosis will be described, and then some of the single compounds isolated from herbal medicines, including salvianolic acids, oxymatrine, curcumin, tetrandrine, etc. will be discussed from their effects to the molecular mechanism behind. Molecular targets of the compounds are analyzed by network pharmacology approach, and TGFb/SMAD was identified as the most common pathway. This review serves to summarize the current findings of herbal medicines combining with modern medicines in the area of fibrosis. It hopefully provides insights in further pharmaceutical research directions.

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“…Tetrandrine, a compound isolated from Stephania tetandra and other Chinese herbs, is a calcium channel blocker. 14 Previous studies demonstrated that tetrandrine and its derivatives could reverse MDR in animal models or cell lines derived from osteosarcoma, 15 breast cancer, 16 and leukemia. 17 However, few studies have investigated whether tetrandrine reverses MDR in laryngeal cancer.…”

Section: Introductionmentioning

confidence: 99%

Tetrandrine partially reverses multidrug resistance of human laryngeal cancer cells

Wang

et al. 2020

J Int Med Res

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Objective Studies have demonstrated that tetrandrine reverses multidrug resistance (MDR) in animal models or cell lines derived from multiple cancer types. We examined the potential MDR reversal activity of tetrandrine in a multidrug-resistant variant of a human laryngeal cancer Hep-2 cell line and explored potential mechanisms involved. Methods We developed the multidrug-resistant variant cell line (Hep-2/v) by exposing Hep-2 cells to stepwise increasing concentrations of vincristine (VCR). After Hep-2 or Hep-2/v cells were treated with tetrandrine (2.52 µg/mL), MDR was measured by MTT assay, rhodamine 123 retention was measured by flow cytometry, and mRNA and protein expression of multidrug resistance 1 (MDR1), regulator of G-protein signaling 10 (RGS10), high-temperature requirement protein A1 (HTRA1), and nuclear protein 1 (NUPR1) were detected by real-time reverse transcription-PCR and western blotting, respectively. Results Tetrandrine significantly lowered the half-maximal inhibitory concentration (IC50) of VCR in Hep-2/v cells, resulting in a 2.22-fold reversal of MDR. Treatment with tetrandrine increased rhodamine 123 retention, downregulated the mRNA and protein expression of MDR1 and RGS10, and upregulated expression of HTRA1 in Hep-2/v cells. Conclusion We showed that tetrandrine exerts anti-MDR activity in Hep-2/v cells, possibly by inhibiting MDR1 overexpression-mediated drug efflux and by altering expression of HTRA1 and RGS10.

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Tetrandrine and cancer – An overview on the molecular approach

Cited by 83 publications

References 144 publications

The impact of ATP-binding cassette transporters on metabolic diseases

The impact of ATP-binding cassette transporters on metabolic diseases

Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era?

Tetrandrine partially reverses multidrug resistance of human laryngeal cancer cells

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