“…With tetramethylammonium glycinate it was possible to obtain high yields of the N-acetyl derivatives of isoindoles 11, which were easily transformed by saponification into the analogs 12 unsubstituted at the nitrogen atom [23].…”
Section: Intermolecular Cyclization Of 12-disubstituted Cyclohexenesmentioning
“…With tetramethylammonium glycinate it was possible to obtain high yields of the N-acetyl derivatives of isoindoles 11, which were easily transformed by saponification into the analogs 12 unsubstituted at the nitrogen atom [23].…”
Section: Intermolecular Cyclization Of 12-disubstituted Cyclohexenesmentioning
Tetramethylammonium Glycinate: A New Reagent for Improved Pyrrole Synthesis by (3 + 2)Cyclization.-The 5-tert-butyl-4,5,6,7tetrahydroindole (V) is prepared from 4-tert-butyl-2-formylcyclohexanone (I) and tetramethylammonium glycinate (II) by (3 + 2)cyclization. If lithium, potassium, or thallium glycinate are employed instead of (II) or the enamine (VII) instead of (I) or if triethylamine is used as the base in the cyclization step, lower yields are obtained. -(ANSARI, M. A.; CRAIG, J. C.; Synth.
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