Tetracycline resistance genes in activated sludge wastewater treatment plants

Auerbach, Eric; Seyfried, Erin E.; McMahon, Katherine D.

doi:10.1016/j.watres.2006.11.045

Cited by 474 publications

(238 citation statements)

References 28 publications

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“…18,21,33,34 We found that the enrichment of ARGs was much higher in WQT than in other RWI samples, which might be caused by the higher abundances of residual antibiotics and ARGs in WWTPs, as WWTPs are considered important reservoirs of ARGs. 15,26,34 Other factors could also result in this phenomenon, such as different irrigation histories (SI Table S1), irrigation volume, as well as the native abundance of ARGs in soil. 19,24 Although the abundances of some ARGs in this study were less than previous studies, 27,35 the findings could still demonstrate that the continuous release of residual ARGs and antibiotics from WWTPs effluent could result in the dissemination of ARGs in the downstream environment.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Thus, aminoglycoside resistance genes were more easily enriched than other types of ARGs, which might be related to the common use of aminoglycosides. 15,27 Previous studies demonstrate that treated wastewater irrigation results in fluctuations of bacterial phyla, which further cause the fluctuations in the relative abundance of different ARG families. 36 SI Figure S3 illustrates the profile of statistically enriched ARGs in each RWI sample.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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High Throughput Profiling of Antibiotic Resistance Genes in Urban Park Soils with Reclaimed Water Irrigation

Wang

Qiao

et al. 2014

Environ. Sci. Technol.

367

194

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Reclaimed water irrigation (RWI) in urban environments is becoming popular, due to rapid urbanization and water shortage. The continuous release of residual antibiotics and antibiotic resistance genes (ARGs) from reclaimed water could result in the dissemination of ARGs in the downstream environment. This study provides a comprehensive profile of ARGs in park soils exposed to RWI through a high-throughput quantitative PCR approach. 147 ARGs encoding for resistance to a broad-spectrum of antibiotics were detected among all park soil samples. Aminoglycoside and beta-lactam were the two most dominant types of ARGs, and antibiotic deactivation and efflux pump were the two most dominant mechanisms in these RWI samples. The total enrichment of ARGs varied from 99.3-fold to 8655.3-fold compared to respective controls. Six to 60 ARGs were statistically enriched among these RWI samples. Four transposase genes were detected in RWI samples. TnpA-04 was the most enriched transposase gene with an enrichment was up to 2501.3-fold in Urumqi RWI samples compared with control soil samples. Furthermore, significantly positive correlation was found between ARGs and transposase abundances, indicating that transposase might be involved in the propagation of ARGs. This study demonstrated that RWI resulted in the enrichment of ARGs in urban park soils.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

High Throughput Profiling of Antibiotic Resistance Genes in Urban Park Soils with Reclaimed Water Irrigation

Wang

Qiao

et al. 2014

Environ. Sci. Technol.

367

194

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“…Since ARGs are regarded as emerging contaminants, increasing attentions have been paid to their fate in various WWTPs (Auerbach et al, 2007;Chen and Zhang, 2013;Chen et al, 2014). The previous study by Chen and Zhang (2013) showed the same performance of the constructed wetlands in the removal of ARGs with conventional WWTPs and even a better reduction of relative abundance.…”

Section: Discussionmentioning

confidence: 96%

Removal of antibiotics and antibiotic resistance genes from domestic sewage by constructed wetlands: Optimization of wetland substrates and hydraulic loading

Chen

Wei

Liu

et al. 2016

Science of The Total Environment

225

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“…Therefore, culture-independent methods are important complements to assess the occurrence of antibiotic resistance in the environment. Cultureindependent approaches, mainly real-time quantitative PCR (qPCR), have gained popularity (Auerbach et al 2007;Zhang et al 2009;LaPara et al 2011;Laht et al 2014;Narciso-da-Rocha et al 2014;Rodriguez-Mozaz et al 2015). These methods, although offering a good overview of the occurrence of antibiotic resistance in different types of environment (Vaz-Moreira et al 2014; Fig.…”

Section: Methods Harmonization and Data Sharingmentioning

confidence: 99%

Antibiotic resistance in urban aquatic environments: can it be controlled?

Manaia

Macedo

Fatta‐Kassinos

et al. 2015

Appl Microbiol Biotechnol

173

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Over the last decade, numerous evidences have contributed to establish a link between the natural and human-impacted environments and the growing public health threat that is the antimicrobial resistance. In the environment, in particular in areas subjected to strong anthropogenic pressures, water plays a major role on the transformation and transport of contaminants including antibiotic residues, antibiotic-resistant bacteria, and antibiotic resistance genes. Therefore, the urban water cycle, comprising water abstraction, disinfection, and distribution for human consumption, and the collection, treatment, and delivery of wastewater to the environment, is a particularly interesting loop to track the fate of antibiotic resistance in the environment and to assess the risks of its trans-mission back to humans. In this article, the relevance of different transepts of the urban water cycle on the potential enrichment and spread of antibiotic resistance is reviewed. According to this analysis, some gaps of knowledge, research needs, and control measures are suggested. The critical rationale behind the measures suggested and the desirable involvement of some key action players is also discussed.

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Tetracycline resistance genes in activated sludge wastewater treatment plants

Cited by 474 publications

References 28 publications

High Throughput Profiling of Antibiotic Resistance Genes in Urban Park Soils with Reclaimed Water Irrigation

High Throughput Profiling of Antibiotic Resistance Genes in Urban Park Soils with Reclaimed Water Irrigation

Removal of antibiotics and antibiotic resistance genes from domestic sewage by constructed wetlands: Optimization of wetland substrates and hydraulic loading

Antibiotic resistance in urban aquatic environments: can it be controlled?

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