Tetracycline Labelling Methods of Measuring the Growth of Bones in the Rat

Abstract

The observation of Milch and his associates in 1957 that tetracycline becomes localised in areas of new bone formation has been confirmed on many occasions

Alteration of Epiphyseal Growth by an Experimentally Produced Angular Deformity

“…No significant difference was seen in the longitudinal growth of the fractured and control legs. The growth corresponded to that recorded with tetracycline labelling in a normal series by Tapp (1966).…”

Mechanical Properties of Fractured and Intact Rat Femora Evaluated by Bending, Torsional and Tensile Tests

“…Since most of the longitudinal growth of the rat femur occurs at the distal epiphysis (Tapp 1966), the fracture location was probably still nearer the middle of the femur when the experiment started. With a coefficient of variance for the fracture location of only 0.04, our fracturing forceps proved to be a reliable device to produce standardized, closed femoral fractures.…”

The proto‐oncogene C‐myc is involved in cell differentiation as well as cell proliferation: Studies on growth plate chondrocytes in situ

“…Indirect evidence exists to support a role for c-myc expression in chondrocyte differentiation; transforming growth factor p, which is known to accumulate and be involved in hypertrophic chondrocyte differentiation (Rosen et al, 1988;Rosier et al, 1989;Seyedin et al, 1987) action modulated by c-myc expression in both colon carcinoma cells (Mulder et a]., 1990) and keratinocytes (Pietenpol et al, 1990). The increased longitudinal bone growth rate of the chick tibiotarsi (Thorp, 1988) in comparison to the rat tibia (Tapp, 1966;Lynch and Taylor 1990) is undoubtedly due to differences in the regulation by genetic and endocrine factors which influence the activity of the growth plate chondrocytes (Hunziker and Schenk, 1989). These authors have argued that parameters such as cell proliferation and growth plate height bear limited relationship to rates of linear bone growth.…”