Tetrabromobisphenol A – Toxicity, environmental and occupational exposures

Jarosiewicz, Monika; Bukowska, Bożena

doi:10.13075/mp.5893.00491

Cited by 18 publications

(7 citation statements)

References 40 publications

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“…79-94-7) and tetrachlorobisphenol A (TCBPA; 2,2′,6,6′-tetrachloro-4,4′-isopropylidenediphenol; CAS registry no. 79-95-8) are the most widely produced and used owing to their efficient fire resistance and cost-effectiveness [ [3] , [4] , [5] , [6] ]. TBBPA and TCBPA have recently attracted considerable attention because of their release into the environment through their persistent use and posed serious threats to living organisms [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways

Suyama

Kesamaru

Okubo

et al. 2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways

Suyama

Kesamaru

Okubo

et al. 2023

Heliyon

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“…170 thousand tones, which accounted for approx. 60% of the production of all brominated FRs worldwide ( 2 ). Due to massive production of TBBPA, this substance has been detected in the air, inhaled dust as well as in terrestrial and aquatic ecosystems ( 2 , 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

“…60% of the production of all brominated FRs worldwide ( 2 ). Due to massive production of TBBPA, this substance has been detected in the air, inhaled dust as well as in terrestrial and aquatic ecosystems ( 2 , 4 , 5 ). Tetrabromobisphenol S (TBBPS) was introduced into the market as TBBPA substitute.…”

Section: Introductionmentioning

confidence: 99%

Genotoxic Mechanism of Action of TBBPA, TBBPS and Selected Bromophenols in Human Peripheral Blood Mononuclear Cells

et al. 2022

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Bromophenolic flame retardants (BFRs) are a large group of synthetic substances used in the industry in order to reduce the flammability of synthetic materials used in electrical and electronic devices, textiles, furniture and other everyday products. The presence of BFRs has been documented in the environment, food, drinking water, inhaled dust and the human body. Due to the widespread exposure of the general population to BFRs and insufficient knowledge on their toxic action, including genotoxic potential, we have compared the effect of tetrabromobisphenol A (TBBPA), tetrabromobisphenol S (TBBPS), 2,4,6,-tribromophenol (2,4,6-TBP) and pentabromophenol (PBP) on DNA damage in human peripheral blood mononuclear cells (PBMCs) (playing a crucial role in the immune system) as well as examined underlying mechanism of action of these substances. The cells were incubated for 24 h with studied compounds in the concentrations ranging from 0.01 to 10 µg/mL. The study has shown that examined BFRs induced single and, to a lesser extent, double strand-breaks formation and caused oxidative damage to pyrimidines, and particularly to purines in the incubated cells. PBMCs efficiently repaired the DNA strand-breaks induced by BFRs, but they were unable to remove completely damaged DNA (except cells treated with TBBPS). The greatest changes in the above-mentioned parameters were observed in cells incubated with TBBPA, while the smallest in PBMCs treated with TBBPS. The results have also revealed that tested compounds do not form adducts with DNA in PBMCs, while the observed changes were the most probably induced by indirect DNA-damaging agents, such as ROS and other reactive species.

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“…TBBPA and its related compounds can leach into the environment and produce adverse effects on human health. Human exposure to TBBPA occurs by inhalation of dust, dermal contact, and ingestion 123. TBBPA has been found in commercial drinking water stored in reusable polycarbonate containers and in seafood 4.…”

Section: Introductionmentioning

confidence: 99%

Tetrabromobisphenol A Promotes the Osteoclastogenesis of RAW264.7 Cells Induced by Receptor Activator of NF-kappa B Ligand In Vitro

et al. 2019

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BackgroundTetrabromobisphenol A (TBBPA), one of the most widely used brominated flame-retardants, is a representative persistent organic pollutants group. Studies on TBBPA toxicity have been conducted using various target cells; however, few studies have investigated TBBPA toxicity in bone cells. Therefore, this study investigated the in vitro effects of TBBPA on osteoclasts, a cell type involved in bone metabolism.MethodsRAW264.7 cells were cultured in medium containing 50 ng/mL receptor activator of nuclear factor kappa B ligand (RANKL) and varying concentrations of TBBPA. To evaluate the effects of TBBPA on the differentiation and function of osteoclasts, osteoclast-specific gene expression, tartrate-resistant acid phosphatase (TRAP) activity, bone resorbing activity, mitochondrial membrane potential (MMP) and mitochondrial superoxide were measured.ResultsThe presence of 20 μM TBBPA significantly increased TRAP activity in RANKL-stimulated RAW264.7 cells, the bone resorbing activity of osteoclasts, and the gene expression of Akt2, nuclear factor of activated T-cells cytoplasmic 1, and chloride channel voltage-sensitive 7. However, TBBPA treatment caused no change in the expression of carbonic anhydrase II, cathepsin K, osteopetrosis-associated transmembrane protein 1, Src, extracellular signal-related kinase, GAB2, c-Fos, or matrix metalloproteinase 9. Furthermore, 20 μM TBBPA caused a significant decrease in MMP and a significant increase in mitochondrial superoxide production.ConclusionThis study suggests that TBBPA promotes osteoclast differentiation and activity. The mechanism of TBBPA-stimulated osteoclastogenesis might include increased expression of several genes involved in osteoclast differentiation and reactive oxygen species production.

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Tetrabromobisphenol A – Toxicity, environmental and occupational exposures

Cited by 18 publications

References 40 publications

High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways

High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways

Genotoxic Mechanism of Action of TBBPA, TBBPS and Selected Bromophenols in Human Peripheral Blood Mononuclear Cells

Tetrabromobisphenol A Promotes the Osteoclastogenesis of RAW264.7 Cells Induced by Receptor Activator of NF-kappa B Ligand In Vitro

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