TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells

Fan, Jiangxia; Zhang, Yan; Mu, Junhao; He, Xueling; Shao, Bianfei; Zhou, Dishu; Peng, Weiyan; Tang, Jun; Jiang, Yu; Ren, Guosheng; Xiang, Tingxiu

doi:10.1186/s13148-018-0535-7

Cited by 32 publications

(37 citation statements)

References 57 publications

(65 reference statements)

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“…Microarray cluster analysis of human embryonic cancer cell lines showed that TET1 was mainly enriched in promoter regions of genes involved in cell proliferation, exercise, angiogenesis and DNA damage repair by mediating 5-hmC [36]. Increasing evidence suggested that TET1 is a tumor suppressor in many types of cancer [23,26,[37][38][39]. These reports can further con rm our results.…”

Section: Discussionsupporting

confidence: 86%

Epigenetic silencing of TET1 mediated hydroxymethylation of base excision repair pathway during lung carcinogenesis

Chen

et al. 2021

Environmental Pollution

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Section: Discussionsupporting

confidence: 86%

Epigenetic silencing of TET1 mediated hydroxymethylation of base excision repair pathway during lung carcinogenesis

Chen

et al. 2021

Environmental Pollution

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“…TET1 protein can lead to DNA demethylation by oxidizing 5mC to 5hmC, 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) [40]. A previous study provided evidence that TET1 exerts its anti-tumor functions in cancer cells by several mechanisms, including suppressing Wnt/β-catenin signaling via the demethylation of Wnt antagonists and promoting tumor suppressor gene expression by demethylating a CpG site within the tumor suppressor gene promoter [41–43]. However, the molecular mechanism of the induction of TET1 and its role in tumor progression are still obscure.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA circTRIM33–12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression

et al. 2019

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Background Recently, the dysregulation of circular RNA (circRNA) have been shown to have important regulatory roles in cancer development and progression, including hepatocellular carcinoma (HCC). However, the roles of most circRNAs in HCC are still unknown. Methods The expression of circular tripartite motif containing 33–12 (circTRIM33–12) in HCC tissues and cell lines was detected by qRT-PCR. The role of circTRIM33–12 in HCC progression was assessed by western blotting, CCK-8, flow cytometry, transwell and a subcutaneous tumor mouse assays both in vitro and in vivo. In vivo circRNA precipitation, RNA immunoprecipitation, luciferase reporter assays were performed to evaluate the interaction between circTRIM33–12 and miR-191. Results Here, we found that circTRIM33–12, is downregulated in HCC tissues and cell lines. The downregulation of circTRIM33–12 in HCC was significantly correlated with malignant characteristics and served as an independent risk factor for the overall survival (OS) and recurrence-free survival (RFS) of patients with HCC after surgery. The reduced expression of circTRIM33–12 in HCC cells increases tumor proliferation, migration, invasion and immune evasion. Mechanistically, we demonstrated that circTRIM33–12 upregulated TET1 expression by sponging miR-191, resulting in significantly reduced 5-hydroxymethylcytosine (5hmC) levels in HCC cells. Conclusions These results reveal the important role of circTRIM33–12 in the proliferation, migration, invasion and immune evasion abilities of HCC cells and provide a new perspective on circRNAs in HCC progression. Electronic supplementary material The online version of this article (10.1186/s12943-019-1031-1) contains supplementary material, which is available to authorized users.

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“…In contrast, DACT2 and WIF1 were downregulated in the joint capsule of dysplastic joints compared to control joints. The DACT gene family encodes multifunctional proteins that are important modulators of Wnt and TGF‐β developmental signaling pathways . The DACT gene family shows spatial disparities in expression during development of teeth, another mesenchymal tissue.…”

Section: Discussionmentioning

confidence: 99%

Gene expression in hip soft tissues in incipient canine hip dysplasia and osteoarthritis

Todhunter

Garrison

Jordan

et al. 2018

Journal Orthopaedic Research

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Canine hip dysplasia and developmental dysplasia of the human hip share demographic, phenotypic, and clinical features including the predisposition to develop osteoarthritis in affected joints. To support the results of genetic mapping studies for CHD and its concomitant osteoarthritis with functional information, we performed RNA-seq on hip capsule and teres ligament of affected and unaffected dogs. RNA seq showed that expressed genes segregated according age, capsule or ligament, and hip phenotype. Expression of HHIP, DACT2, and WIF1 was significantly higher in capsule from control hips than dysplastic hips indicating a disruption of the hedgehog signaling pathway. Expression of SPON 1, a key component of the WNT pathway, was increased significantly in both dysplastic capsule and ligament while FBN2 and EMILIN3 were significantly increased in dysplastic capsule. Of genes associated with human hip osteoarthritis, expression of ACAN, IGF1, CILP2, COL11A1, COL8A1, and HAPLN was increased significantly in dysplastic capsule. The significant increase in expression of PLA2F, TNFRSF, TMEM, and IGFBP in dysplastic capsule indicated an injury response. Gene set enrichment analysis revealed that genes involved in extracellular matrix structure, epithelial to mesenchymal transition, myogenesis, growth factor signaling, cancer and immune pathways were enriched in dysplastic capsule. For teres ligament from dysplastic joints, genes in retinoic signaling pathways and those encoding extracellular matrix molecules, but not proteoglycans, were enriched. Hip tissues respond to abnormal mechanics early in dysplastic hip development and these pathways present targets for intervention in the early synovitis and capsulitis secondary to canine and human hip dysplasia. ß

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TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells

Cited by 32 publications

References 57 publications

Epigenetic silencing of TET1 mediated hydroxymethylation of base excision repair pathway during lung carcinogenesis

Epigenetic silencing of TET1 mediated hydroxymethylation of base excision repair pathway during lung carcinogenesis

Circular RNA circTRIM33–12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression

Gene expression in hip soft tissues in incipient canine hip dysplasia and osteoarthritis

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