2018
DOI: 10.1186/s13148-018-0535-7
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TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells

Abstract: BackgroundTET1 is a tumor suppressor gene (TSG) that codes for ten-eleven translocation methyl cytosine dioxygenase1 (TET1) catalyzing the conversion of 5-methylcytosine to 5-hydroxy methyl cytosine as a first step of TSG demethylation. Its hypermethylation has been associated with cancer pathogenesis. However, whether TET1 plays any role in nasopharyngeal carcinoma (NPC) remains unclear. This study investigated the expression and methylation of TET1 in NPC and confirmed its role and mechanism as a TSG.Results… Show more

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Cited by 33 publications
(38 citation statements)
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“…Microarray cluster analysis of human embryonic cancer cell lines showed that TET1 was mainly enriched in promoter regions of genes involved in cell proliferation, exercise, angiogenesis and DNA damage repair by mediating 5-hmC [36]. Increasing evidence suggested that TET1 is a tumor suppressor in many types of cancer [23,26,[37][38][39]. These reports can further con rm our results.…”
Section: Discussionsupporting
confidence: 86%
“…Microarray cluster analysis of human embryonic cancer cell lines showed that TET1 was mainly enriched in promoter regions of genes involved in cell proliferation, exercise, angiogenesis and DNA damage repair by mediating 5-hmC [36]. Increasing evidence suggested that TET1 is a tumor suppressor in many types of cancer [23,26,[37][38][39]. These reports can further con rm our results.…”
Section: Discussionsupporting
confidence: 86%
“…TET1 protein can lead to DNA demethylation by oxidizing 5mC to 5hmC, 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) [40]. A previous study provided evidence that TET1 exerts its anti-tumor functions in cancer cells by several mechanisms, including suppressing Wnt/β-catenin signaling via the demethylation of Wnt antagonists and promoting tumor suppressor gene expression by demethylating a CpG site within the tumor suppressor gene promoter [4143]. However, the molecular mechanism of the induction of TET1 and its role in tumor progression are still obscure.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, DACT2 and WIF1 were downregulated in the joint capsule of dysplastic joints compared to control joints. The DACT gene family encodes multifunctional proteins that are important modulators of Wnt and TGF‐β developmental signaling pathways . The DACT gene family shows spatial disparities in expression during development of teeth, another mesenchymal tissue.…”
Section: Discussionmentioning
confidence: 99%