Tests of Aerosols of Deet for Protection of Livestock from Biting Flies12

Blume, Richard R.; Roberts, R. H.; Eschle, J. L.; Matter, Jesse J.

doi:10.1093/jee/64.5.1193

Cited by 15 publications

(4 citation statements)

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“…In experimental and domestic animals, similar skin reactions have been described (AMBROSE 1959; KEPLINGER et at. 1961;MORISON et al 1963;PALMER 1969;KURASOVA & LESHCHEV 1969;BLUME et al 1971), again frequently showing dose dependence.…”

Section: Discussionmentioning

confidence: 98%

Distribution and Fate of the Insect Repellent ¹⁴C‐N, N‐diethyl‐m‐toluamide in the Animal Body. II. Distribution and Excretion after Cutaneous Application

Blomquist

Thorsell

1977

Acta Pharmacologica et Toxicologica

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The tissue distribution of 14C‐labelled N,N‐diethyl‐m‐toluamide (DEET), a widely used mosquito repellent, was studied by means of whole‐body auto‐radiography after cutaneous application to mice. The early picture was very similar to that previously observed after intravenous injection of the substance, with high concentration of radioactivity mainly in the lacrimal gland, liver, bile, intestinal contents, kidney, urine, and nasal mucosa. Urinary excretion in mice was highest early after application whereas in a human volunteer maximal excretion appeared only after several hours. In mice a low but significant excretion persisted throughout the observation time of one month, probably emanating from the considerable amount of radioactivity remaining in the smeared skin area, as observed both autoradiographically and by means of quantitative measurements.

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Section: Discussionmentioning

confidence: 98%

Distribution and Fate of the Insect Repellent ¹⁴C‐N, N‐diethyl‐m‐toluamide in the Animal Body. II. Distribution and Excretion after Cutaneous Application

Blomquist

Thorsell

1977

Acta Pharmacologica et Toxicologica

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“…Since its first commercial application in 1956, DEET has become one of the most widely used insect repellents in both human and veterinary use. 12 Repeated studies show that DEET is highly efficient in repelling a wide variety of arthropods, [17][18][19][20][21][22] particularly with respect to mosquitoes, sand flies, and ticks given their major role in spreading diseases in both human and animals. In most cases, a single skin application of DEET was effective in repelling the insects for several hours.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of N,N-diethyl-m-toluamide (DEET) as a topical agent for preventing skin penetration by cercariae of Schistosoma mansoni.

Salafsky

Kalyanasundaram

et al. 1998

The American Journal of Tropical Medicine and Hygiene

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The effect of skin application of N,N-diethyl-m-toluamide (DEET) on the penetration and migration behavior of cercariae of Schistosoma mansoni was evaluated in vitro and in vivo in a mouse model. These studies showed that DEET at concentrations of 7.5% or higher was 100% effective in immobilizing and killing cercariae of S. mansoni in vitro. Ultrastructural studies on such DEET-exposed cercariae showed transformative and degenerative changes involving both tegument and deeper parenchymal structures. Fatal tissue lesions were evident as early as 5 min postexposure to DEET, and became more extensive with increasing exposure time. Cutaneous application of DEET (as a pure chemical in isopropanol or as a commercial insect repellent preparation) was more than 99% effective in preventing entry of S. mansoni cercariae into the mouse tail skin. Radiolabeling and tracer studies confirmed that 7.5% DEET applied to the skin prior to infection was highly effective in preventing schistosomular migration to the lungs.

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“…Originally developed as a mosquito repellent (2), DEET successfully repels several genera of mosquitoes (3–6). DEET affects many other blood‐seeking invertebrates as well, including sand flies (7), assassin bugs (8), Simuliid flies (9), Tsetse flies (10), face flies (11), ticks (12,13), and even leeches (14). That DEET also affects fruit flies suggests an invertebrate‐repelling mechanism not limited to the prevention of blood feeding (15,16).…”

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confidence: 99%

DEET (N,N‐Diethyl‐meta‐toluamide) Induced Delay of Blowfly Landing and Oviposition Rates on Treated Pig Carrion (Sus scrofaL.)

Shelomi

Matern

Dinstell

et al. 2012

Journal of Forensic Sciences

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The question of whether the insect repellent N,N-Diethyl-meta-toluamide (DEET) affected fly attraction, oviposition, and larval development was investigated; in part, to determine whether the common habit of wearing DEET as a repellent could affect the rate of human decomposition. Experiments using pig surrogates of human decedents were carried out in a rural environment. Dead piglets were sprayed with DEET, and fly behavior, colonization levels, and maggot development were compared with those in nonsprayed controls. Piglets treated with DEET experienced significant delays in fly visitation and oviposition and delayed appearance of each larval instar, as well as reduced total larval numbers (p < 0.01 for all variables), with subsequently reduced decomposition (p < 0.05). Such changes in fly behavior and larval population development would significantly impact the estimation of the period following the death from entomological evidence in decedents wearing DEET at the time of their death.

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Tests of Aerosols of Deet for Protection of Livestock from Biting Flies12

Cited by 15 publications

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Distribution and Fate of the Insect Repellent ¹⁴C‐N, N‐diethyl‐m‐toluamide in the Animal Body. II. Distribution and Excretion after Cutaneous Application

Distribution and Fate of the Insect Repellent ¹⁴C‐N, N‐diethyl‐m‐toluamide in the Animal Body. II. Distribution and Excretion after Cutaneous Application

Evaluation of N,N-diethyl-m-toluamide (DEET) as a topical agent for preventing skin penetration by cercariae of Schistosoma mansoni.

DEET (N,N‐Diethyl‐meta‐toluamide) Induced Delay of Blowfly Landing and Oviposition Rates on Treated Pig Carrion (Sus scrofaL.)

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Tests of Aerosols of Deet for Protection of Livestock from Biting Flies12

Cited by 15 publications

References 0 publications

Distribution and Fate of the Insect Repellent 14C‐N, N‐diethyl‐m‐toluamide in the Animal Body. II. Distribution and Excretion after Cutaneous Application

Distribution and Fate of the Insect Repellent 14C‐N, N‐diethyl‐m‐toluamide in the Animal Body. II. Distribution and Excretion after Cutaneous Application

Evaluation of N,N-diethyl-m-toluamide (DEET) as a topical agent for preventing skin penetration by cercariae of Schistosoma mansoni.

DEET (N,N‐Diethyl‐meta‐toluamide) Induced Delay of Blowfly Landing and Oviposition Rates on Treated Pig Carrion (Sus scrofaL.)

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Distribution and Fate of the Insect Repellent ¹⁴C‐N, N‐diethyl‐m‐toluamide in the Animal Body. II. Distribution and Excretion after Cutaneous Application

Distribution and Fate of the Insect Repellent ¹⁴C‐N, N‐diethyl‐m‐toluamide in the Animal Body. II. Distribution and Excretion after Cutaneous Application